{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:12:38Z","timestamp":1793059958895,"version":"4.5.0"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T00:00:00Z","timestamp":1452902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T00:00:00Z","timestamp":1452902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>Exposure to hepatitis E virus (HEV) is common in the United States, but there are few data on prevalence of HEV\/human immunodeficiency virus (HIV) coinfection in U.S. populations. We tested 2,919 plasma samples collected from HIV\u2010infected (HIV<jats:sup>+<\/jats:sup>) women and men enrolled in U.S. cohort studies for HEV viremia using a high\u2010throughput nucleic acid testing (NAT) platform. NAT<jats:sup>+<\/jats:sup> samples were confirmed by real\u2010time polymerase chain reaction. Samples were selected for testing primarily on the basis of biomarkers of liver disease and immune suppression. Prevalence of HEV viremia was 3 of 2,606 and 0 of 313 in tested plasma samples collected from HIV<jats:sup>+<\/jats:sup> women and men, respectively. All HEV isolates were genotype 3a. Based on follow\u2010up testing of stored samples, 1 woman had chronic HEV infection for &gt;4 years whereas 2 women had acute HEV detectable at only a single study visit. <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic> To our knowledge, this is the first reported case of chronic HEV infection in an HIV<jats:sup>+<\/jats:sup> U.S. individual. We also confirm that chronic HEV infection can persist despite a CD4<jats:sup>+<\/jats:sup> count &gt;200 cells\/mm<jats:sup>3<\/jats:sup>. Overall, though, these data suggest that HEV infection is rare in the HIV<jats:sup>+<\/jats:sup> U.S. population. (H<jats:sc>epatology<\/jats:sc> 2016;63:712\u2013720)<\/jats:p>","DOI":"10.1002\/hep.28384","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T07:12:33Z","timestamp":1449645153000},"page":"712-720","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":46,"title":["Acute and Chronic Hepatitis E Virus Infection in Human Immunodeficiency Virus\u2010Infected U.S. Women"],"prefix":"10.1097","volume":"63","author":[{"given":"Mark H.","family":"Kuniholm","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Population Health,Albert Einstein College of Medicine,Bronx,NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Ong","sequence":"additional","affiliation":[{"name":"Hologic, Inc.,San Diego,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris M.","family":"Hogema","sequence":"additional","affiliation":[{"name":"Sanquin Research and Diagnostics, Departments of Virology,Blood\u2010borne Infections and the National Screening Laboratory,Amsterdam,The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Koppelman","sequence":"additional","affiliation":[{"name":"Sanquin Research and Diagnostics, Departments of Virology,Blood\u2010borne Infections and the National Screening Laboratory,Amsterdam,The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Anastos","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health,Albert Einstein College of Medicine,Bronx,NY"},{"name":"Department of Medicine,Montefiore Medical Center,Bronx,NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion G.","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Medicine,University of California,San 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