{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:57:52Z","timestamp":1790247472155,"version":"4.1.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Idiopathic noncirrhotic portal hypertension is a heterogeneous group of diseases characterized by portal hypertension in the absence of cirrhosis. The efficacy and safety of transjugular intrahepatic portosystemic shunt (TIPS) in this population are unknown. The charts of patients with idiopathic noncirrhotic portal hypertension undergoing TIPS in seven centers between 2000 and 2014 were retrospectively reviewed. Forty\u2010one patients were included. Indications for TIPS were recurrent variceal bleeding (n\u2009=\u200925) and refractory ascites (n\u2009=\u200916). Patients were categorized according to the presence (n\u2009=\u200927) or absence (n\u2009=\u200914) of significant extrahepatic comorbidities. Associated conditions were hematologic, prothrombotic, neoplastic, immune, and exposure to toxins. During follow\u2010up (mean 27\u2009\u00b1\u200929 months), variceal rebleeding occurred in 7\/25 (28%), including three with early thrombosis of the stent. Post\u2010TIPS overt hepatic encephalopathy was present in 14 patients (34%). Eleven patients died, five due the liver disease or complications of the procedure and six because of the associated comorbidities. The procedure was complicated by hemoperitoneum in four patients (10%), which was fatal in one case. Serum creatinine (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.005), ascites as indication for TIPS (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.04), and the presence of significant comorbidities (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.01) at the time of the procedure were associated with death. Mortality was higher in patients with significant comorbidities and creatinine \u2265100 \u03bcmol\/L (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009&lt;\u20090.001). <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>: In patients with idiopathic noncirrhotic portal hypertension who have normal kidney function or do not have severe extrahepatic conditions, TIPS is an excellent option to treat severe complications of portal hypertension. (H<jats:sc>epatology<\/jats:sc> 2016;64:224\u2013231)<\/jats:p>","DOI":"10.1002\/hep.28547","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T06:59:42Z","timestamp":1458370782000},"page":"224-231","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":100,"title":["Role of the transjugular intrahepatic portosystemic shunt in the management of severe complications of portal hypertension in idiopathic noncirrhotic portal hypertension"],"prefix":"10.1097","volume":"64","author":[{"given":"Julien","family":"Bissonnette","sequence":"first","affiliation":[{"name":"Service d'H\u00e9patologie, H\u00f4pital Beaujon, APHP,Clichy,France"},{"name":"DHU Unity, H\u00f4pital Beaujon, APHP,Clichy,France"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9,Paris,France"},{"name":"D\u00e9partement Epid\u00e9miologie et Recherche Clinique, H\u00f4pital Beaujon, APHP,Clichy,France"},{"name":"Service d'h\u00e9patologie, H\u00f4pital Saint\u2010Luc,Montr\u00e9al,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Garcia\u2010Pag\u00e1n","sequence":"additional","affiliation":[{"name":"Barcelona Hepatic Hemodynamic Lab and Liver Unit, Hospital Clinic\u2013IDIBAPS and CIBERehd, University of Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"Albillos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, CIBERehd, University of Alcal\u00e1,Madrid,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Turon","sequence":"additional","affiliation":[{"name":"Barcelona Hepatic Hemodynamic Lab and Liver Unit, Hospital Clinic\u2013IDIBAPS and CIBERehd, University of Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Barcelona Hepatic Hemodynamic Lab and Liver Unit, Hospital Clinic\u2013IDIBAPS and CIBERehd, University of Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Tellez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, CIBERehd, University of Alcal\u00e1,Madrid,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Charles","family":"Nault","sequence":"additional","affiliation":[{"name":"APHP, H\u00f4pitaux Universitaires Paris\u2013Seine Saint\u2010Denis, Site Jean Verdier, P\u00f4le d'Activit\u00e9 Canc\u00e9rologique Sp\u00e9cialis\u00e9e, Service d'H\u00e9patologie, Bondy, Inserm, UMR\u20101162, G\u00e9nomique fonctionnelle des Tumeurs solides, Equipe Labellis\u00e9e Ligue Contre le Cancer,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Carbonell","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9patologie, H\u00f4pital Saint\u2010Antoine,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Paul","family":"Cervoni","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9patologie, Centre Hospitalier R\u00e9gional et Universitaire de Besan\u00e7on,Besan\u00e7on,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Abdel Rehim","sequence":"additional","affiliation":[{"name":"Service de radiologie, H\u00f4pital Beaujon,Clichy,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Sibert","sequence":"additional","affiliation":[{"name":"Service de radiologie, H\u00f4pital Beaujon,Clichy,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Bouchard","sequence":"additional","affiliation":[{"name":"Service de radiologie, H\u00f4pital Saint\u2010Luc,Montr\u00e9al,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Perreault","sequence":"additional","affiliation":[{"name":"Service de radiologie, H\u00f4pital Saint\u2010Luc,Montr\u00e9al,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonel","family":"Trebicka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I,University of Bonn,Bonn,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix","family":"Trottier\u2010Tellier","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9patologie, H\u00f4pital Saint\u2010Luc,Montr\u00e9al,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Emmanuel","family":"Rautou","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9patologie, H\u00f4pital Beaujon, APHP,Clichy,France"},{"name":"DHU Unity, H\u00f4pital Beaujon, APHP,Clichy,France"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9,Paris,France"},{"name":"D\u00e9partement Epid\u00e9miologie et Recherche Clinique, H\u00f4pital Beaujon, APHP,Clichy,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique\u2010Charles","family":"Valla","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9patologie, H\u00f4pital Beaujon, APHP,Clichy,France"},{"name":"DHU Unity, H\u00f4pital Beaujon, APHP,Clichy,France"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9,Paris,France"},{"name":"D\u00e9partement Epid\u00e9miologie et Recherche Clinique, H\u00f4pital Beaujon, APHP,Clichy,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Plessier","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9patologie, H\u00f4pital Beaujon, APHP,Clichy,France"},{"name":"DHU Unity, H\u00f4pital Beaujon, APHP,Clichy,France"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9,Paris,France"},{"name":"D\u00e9partement Epid\u00e9miologie et Recherche Clinique, H\u00f4pital Beaujon, APHP,Clichy,France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,5,13]]},"reference":[{"key":"hep28547-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/hep.24422","article-title":"Idiopathic noncirrhotic portal hypertension","volume":"54","year":"2011","journal-title":"Hepatology"},{"key":"hep28547-bib-0002-20241017","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jhep.2013.08.013","article-title":"Non\u2010cirrhotic portal hypertension\u2014diagnosis and management","volume":"60","year":"2014","journal-title":"J Hepatol"},{"key":"hep28547-bib-0003-20241017","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jhep.2010.07.038","article-title":"Obliterative portal venopathy: portal hypertension is not always present at diagnosis","volume":"54","year":"2011","journal-title":"J Hepatol"},{"key":"hep28547-bib-0004-20241017","first-page":"627","article-title":"Liver transplantation for severe intrahepatic noncirrhotic portal hypertension. Liver","volume":"11","year":"2005","journal-title":"Transplant"},{"key":"hep28547-bib-0005-20241017","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1111\/j.1365-2036.2012.05112.x","article-title":"Idiopathic noncirrhotic portal hypertension is associated with poor survival: results of a long\u2010term cohort study","volume":"35","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"hep28547-bib-0006-20241017","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1002\/hep.26904","article-title":"Idiopathic portal hypertension: natural history and long\u2010term outcome","volume":"59","year":"2014","journal-title":"Hepatology"},{"key":"hep28547-bib-0007-20241017","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1136\/gut.51.2.275","article-title":"Idiopathic non\u2010cirrhotic intrahepatic portal hypertension in the West: a re\u2010evaluation in 28 patients","volume":"51","year":"2002","journal-title":"Gut"},{"key":"hep28547-bib-0008-20241017","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.jhep.2010.06.004","article-title":"Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension","volume":"53","year":"2010","journal-title":"J Hepatol"},{"key":"hep28547-bib-0009-20241017","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s12072-007-9010-9","article-title":"Noncirrhotic portal fibrosis\/idiopathic portal hypertension: APASL recommendations for diagnosis and treatment","volume":"1","year":"2007","journal-title":"Hepatol Int"},{"key":"hep28547-bib-0010-20241017","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s10620-010-1278-2","article-title":"Non\u2010cirrhotic intrahepatic portal hypertension: associated gut diseases and prognostic factors","volume":"56","year":"2011","journal-title":"Dig Dis Sci"},{"key":"hep28547-bib-0011-20241017","doi-asserted-by":"crossref","first-page":"e691S","DOI":"10.1378\/chest.11-2300","article-title":"VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence\u2010Based Clinical Practice Guidelines","volume":"141","year":"2012","journal-title":"Chest"},{"key":"hep28547-bib-0012-20241017","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.jhep.2013.06.014","article-title":"TIPS: 25 years later","volume":"59","year":"2013","journal-title":"J Hepatol"},{"key":"hep28547-bib-0013-20241017","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0140-6736(96)08189-5","article-title":"Randomised trial of transjugular\u2010intrahepatic\u2010portosystemic shunt versus endoscopy plus propranolol for prevention of variceal rebleeding","volume":"349","year":"1997","journal-title":"Lancet"},{"key":"hep28547-bib-0014-20241017","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1136\/gut.48.3.390","article-title":"Transjugular intrahepatic portosystemic shunt (TIPS) versus endoscopic variceal ligation in the prevention of variceal rebleeding in patients with cirrhosis: a randomised trial","volume":"48","year":"2001","journal-title":"Gut"},{"key":"hep28547-bib-0015-20241017","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/hep.20364","article-title":"Randomized controlled study of TIPS versus paracentesis plus albumin in cirrhosis with severe ascites","volume":"40","year":"2004","journal-title":"Hepatology"},{"key":"hep28547-bib-0016-20241017","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1053\/gast.2003.50088","article-title":"The North American Study for the Treatment of Refractory Ascites","volume":"124","year":"2003","journal-title":"Gastroenterology"},{"key":"hep28547-bib-0017-20241017","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s00535-010-0282-9","article-title":"Transjugular intrahepatic portosystemic shunt versus paracentesis plus albumin in patients with refractory ascites who have good hepatic and renal function: a prospective randomized trial","volume":"46","year":"2011","journal-title":"J Gastroenterol"},{"key":"hep28547-bib-0018-20241017","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1053\/he.2000.5852","article-title":"A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts","volume":"31","year":"2000","journal-title":"Hepatology"},{"key":"hep28547-bib-0019-20241017","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.jhep.2010.08.001","article-title":"Renal and circulatory dysfunction in cirrhosis: current management and future perspectives","volume":"53","year":"2010","journal-title":"J Hepatol"},{"key":"hep28547-bib-0020-20241017","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1136\/gut.2010.228023","article-title":"Short\u2010 and long\u2010term effects of the transjugular intrahepatic portosystemic shunt on portal vein thrombosis in patients with cirrhosis","volume":"60","year":"2011","journal-title":"Gut"},{"key":"hep28547-bib-0021-20241017","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jhep.2010.06.029","article-title":"Transjugular intrahepatic portosystemic shunt for portal vein thrombosis with symptomatic portal hypertension in liver cirrhosis","volume":"54","year":"2011","journal-title":"J Hepatol"},{"key":"hep28547-bib-0022-20241017","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1053\/gast.2002.37073","article-title":"Transjugular intrahepatic portosystemic shunting versus paracentesis plus albumin for refractory ascites in cirrhosis","volume":"123","year":"2002","journal-title":"Gastroenterology"},{"key":"hep28547-bib-0023-20241017","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1111\/j.1572-0241.2001.03704.x","article-title":"Relationship between pre\u2010TIPS liver perfusion by the portal vein and the incidence of post\u2010TIPS chronic hepatic encephalopathy","volume":"96","year":"2001","journal-title":"Am J Gastroenterol"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.28547","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-201607000-00027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T23:35:46Z","timestamp":1729208146000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-201607000-00027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,13]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.28547","relation":{},"ISSN":["0270-9139","1527-3350"],"issn-type":[{"value":"0270-9139","type":"print"},{"value":"1527-3350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,13]]},"assertion":[{"value":"2015-06-12","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}