{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:16:53Z","timestamp":1780730213391,"version":"3.54.1"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>The appropriate interval between ligation sessions for treatment of esophageal variceal bleeding is uncertain. The optimal interval would provide variceal eradication as rapidly as possible to lessen early rebleeding while minimizing ligation\u2010induced adverse events. We randomly assigned patients hospitalized with acute esophageal variceal bleeding who had successful ligation at presentation to repeat ligation at 1\u2010week or 2\u2010week intervals. Beta\u2010blocker therapy was also prescribed. Ligation was performed at the assigned interval until varices were eradicated and then at 3 and 9 months after eradication. The primary endpoint was the proportion of patients with variceal eradication at 4 weeks. Four\u2010week variceal eradication occurred more often in the 1\u2010week than in the 2\u2010week group: 37\/45 (82%) versus 23\/45 (51%); difference = 31%, 95% confidence interval 12%\u201048%. Eradication occurred more rapidly in the 1\u2010week group (18.1 versus 30.8 days, difference = \u221212.7 days, 95% confidence interval \u221220.0 to \u22125.4 days). The mean number of endoscopies to achieve eradication or to the last endoscopy in those not achieving eradication was comparable in the 1\u2010week and 2\u2010week groups (2.3 versus 2.1), with the mean number of postponed ligation sessions 0.3 versus 0.1 (difference = 0.2, 95% confidence interval \u22120.02 to 0.4). Rebleeding at 4 weeks (4% versus 4%) and 8 weeks (11% versus 9%), dysphagia\/odynophagia\/chest pain (9% versus 2%), strictures (0% versus 0%), and mortality (7% versus 7%) were similar with 1\u2010week and 2\u2010week intervals. <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> One\u2010week ligation intervals led to more rapid eradication than 2\u2010week intervals without an increase in complications or number of endoscopies and without a reduction in rebleeding or other clinical outcomes; the decision regarding ligation intervals may be individualized based on patient and physician preferences and local logistics and resources. 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Report of the Baveno VI consensus workshop: stratifying risk and individualizing care for portal hypertension","volume":"63","year":"2015","journal-title":"J Hepatol"},{"key":"hep28597-bib-0004-20241017","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.gie.2013.07.023","article-title":"The role of endoscopy in the management of variceal hemorrhage","volume":"80","year":"2014","journal-title":"Gastrointest Endosc"},{"key":"hep28597-bib-0005-20241017","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1136\/gut.25.2.129","article-title":"Injection sclerotherapy for esophageal varices: a prospective randomized trial of different treatment schedules","volume":"25","year":"1984","journal-title":"Gut"},{"key":"hep28597-bib-0006-20241017","first-page":"710","article-title":"Comparison of the two time schedules for endoscopic sclerotherapy: a prospective randomised controlled study","volume":"27","year":"1987","journal-title":"Gut"},{"key":"hep28597-bib-0007-20241017","doi-asserted-by":"crossref","first-page":"280","DOI":"10.7326\/0003-4819-123-4-199508150-00007","article-title":"Endoscopic ligation compared with sclerotherapy for treatment of esophageal variceal bleeding: a meta\u2010analysis","volume":"123","year":"1995","journal-title":"Ann Intern Med"},{"key":"hep28597-bib-0008-20241017","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1111\/j.1572-0241.2005.41864.x","article-title":"A randomized trial control trial of bimonthly versus biweekly endoscopic variceal ligation of esophageal varices","volume":"100","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"hep28597-bib-0009-20241017","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1111\/jgh.12538","article-title":"Randomized controlled trial of monthly versus biweekly endoscopic variceal ligation for the prevention of esophageal variceal rebleeding","volume":"29","year":"2014","journal-title":"J Gastroenterol Hepatol"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.28597","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.28597","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hep.28597","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hep.28597","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-201608000-00025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T23:23:30Z","timestamp":1729207410000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-201608000-00025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,17]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.28597","relation":{},"ISSN":["0270-9139","1527-3350"],"issn-type":[{"value":"0270-9139","type":"print"},{"value":"1527-3350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,17]]},"assertion":[{"value":"2016-03-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}