{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:13:16Z","timestamp":1791972796511,"version":"4.3.4"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T00:00:00Z","timestamp":1471996800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T00:00:00Z","timestamp":1471996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>\n                    The presence of an intrahepatic cholangiocarcinoma (iCCA) in a cirrhotic liver is a contraindication for liver transplantation in most centers worldwide. Recent investigations have shown that \u201cvery early\u201d iCCA (single tumors \u22642 cm) may have acceptable results after liver transplantation. This study further evaluates this finding in a larger international multicenter cohort. The study group was composed of those patients who were transplanted for hepatocellular carcinoma or decompensated cirrhosis and found to have an iCCA at explant pathology. Patients were divided into those with \u201cvery early\u201d iCCA and those with \u201cadvanced\u201d disease (single tumor &gt;2 cm or multifocal disease). Between January 2000 and December 2013, 81 patients were found to have an iCCA at explant; 33 had separate nodules of iCCA and hepatocellular carcinoma, and 48 had only iCCA (study group). Within the study group, 15\/48 (31%) constituted the \u201cvery early\u201d iCCA group and 33\/48 (69%) the \u201cadvanced\u201d group. There were no significant differences between groups in preoperative characteristics. At explant, the median size of the largest tumor was larger in the \u201cadvanced\u201d group (3.1 [2.5\u20104.4] versus 1.6 [1.5\u20101.8]). After a median follow\u2010up of 35 (13.5\u201076.4) months, the 1\u2010year, 3\u2010year, and 5\u2010year cumulative risks of recurrence were, respectively, 7%, 18%, and 18% in the very early iCCA group versus 30%, 47%, and 61% in the advanced iCCA group,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.01. The 1\u2010year, 3\u2010year, and 5\u2010year actuarial survival rates were, respectively, 93%, 84%, and 65% in the very early iCCA group versus 79%, 50%, and 45% in the advanced iCCA group,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.02.\n                    <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    Patients with cirrhosis and very early iCCA may become candidates for liver transplantation; a prospective multicenter clinical trial is needed to further confirm these results. (H\n                    <jats:sc>epatology<\/jats:sc>\n                    2016;64:1178\u20101188)\n                  <\/jats:p>","DOI":"10.1002\/hep.28744","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T09:19:38Z","timestamp":1470215978000},"page":"1178-1188","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":348,"title":["Liver transplantation for \u201cvery early\u201d intrahepatic cholangiocarcinoma: International retrospective study supporting a prospective assessment"],"prefix":"10.1097","volume":"64","author":[{"given":"G.","family":"Sapisochin","sequence":"first","affiliation":[{"name":"Multi\u2010Organ Transplant, Division of General Surgery, Toronto General Hospital,University of Toronto,Toronto,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Facciuto","sequence":"additional","affiliation":[{"name":"Recanati\u2010Miller Transplantation Institute,The Mount Sinai Medical Center,New York,NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Rubbia\u2010Brandt","sequence":"additional","affiliation":[{"name":"Service de Pathologie Clinique, Facult\u00e9 de M\u00e9decine,Geneva University Hospitals,Geneva,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Marti","sequence":"additional","affiliation":[{"name":"Recanati\u2010Miller Transplantation Institute,The Mount Sinai Medical Center,New York,NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine,University of California,San Francisco,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.Y.","family":"Yao","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine,University of California,San Francisco,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Vibert","sequence":"additional","affiliation":[{"name":"Centre H\u00e9pato\u2010Biliaire,Paul Brousse Hospital,AP\u2010HP,Villejuif,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Cherqui","sequence":"additional","affiliation":[{"name":"Centre H\u00e9pato\u2010Biliaire,Paul Brousse Hospital,AP\u2010HP,Villejuif,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.R.","family":"Grant","sequence":"additional","affiliation":[{"name":"Multi\u2010Organ Transplant, Division of General Surgery, Toronto General Hospital,University of Toronto,Toronto,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Hernandez\u2010Alejandro","sequence":"additional","affiliation":[{"name":"Division of Transplantation,Western University,London,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.H.","family":"Dale","sequence":"additional","affiliation":[{"name":"Division of Transplantation,Western University,London,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cucchetti","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, General and Transplant Surgery Unit, S. Orsola\u2010Malpighi Hospital, Alma Mater Studiorum,University of Bologna,Bologna,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pinna","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, General and Transplant Surgery Unit, S. Orsola\u2010Malpighi Hospital, Alma Mater Studiorum,University of Bologna,Bologna,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Surgery and Liver Transplantation, Asan Medical Center,University of Ulsan College of Medicine,Seoul,South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.G.","family":"Lee","sequence":"additional","affiliation":[{"name":"Hepatobiliary Surgery and Liver Transplantation, Asan Medical Center,University of Ulsan College of Medicine,Seoul,South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.G.","family":"Agopian","sequence":"additional","affiliation":[{"name":"Dumont\u2010UCLA Liver Cancer and Transplant Centers, Pfleger Liver Institute, Department of Surgery,David Geffen School of Medicine at University of California,Los Angeles,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.W.","family":"Busuttil","sequence":"additional","affiliation":[{"name":"Dumont\u2010UCLA Liver Cancer and Transplant Centers, Pfleger Liver Institute, Department of Surgery,David Geffen School of Medicine at University of California,Los Angeles,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rizvi","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery, William J. von Liebig Transplant Center,Mayo Clinic,Rochester,MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.K.","family":"Heimbach","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery, William J. von Liebig Transplant Center,Mayo Clinic,Rochester,MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Montenovo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplantation,University of Washington,Seattle,WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Reyes","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplantation,University of Washington,Seattle,WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cesaretti","sequence":"additional","affiliation":[{"name":"Department of HPB Surgery and Liver Transplant, Beaujon Hospital,Paris Diderot University\u2013Paris 7,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Soubrane","sequence":"additional","affiliation":[{"name":"Department of HPB Surgery and Liver Transplant, Beaujon Hospital,Paris Diderot University\u2013Paris 7,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Reichman","sequence":"additional","affiliation":[{"name":"Multi\u2010Organ Transplant Institute,Ochsner Medical Center,New Orleans,LA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Seal","sequence":"additional","affiliation":[{"name":"Multi\u2010Organ Transplant Institute,Ochsner Medical Center,New Orleans,LA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.T.W.","family":"Kim","sequence":"additional","affiliation":[{"name":"Annette C. and Harold C. Simmons Transplant Institute,Baylor University Medical Center,Dallas,TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Klintmalm","sequence":"additional","affiliation":[{"name":"Annette C. and Harold C. Simmons Transplant Institute,Baylor University Medical Center,Dallas,TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Sposito","sequence":"additional","affiliation":[{"name":"Department of Surgery, G.I. Surgery, and Liver Transplantation,Istituto Nazionale Tumori,Milan,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Mazzaferro","sequence":"additional","affiliation":[{"name":"Department of Surgery, G.I. Surgery, and Liver Transplantation,Istituto Nazionale Tumori,Milan,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Dutkowski","sequence":"additional","affiliation":[{"name":"Swiss HPB and Transplant Center Zurich, Department of Surgery,University Hospital Zurich,Zurich,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.A.","family":"Clavien","sequence":"additional","affiliation":[{"name":"Swiss HPB and Transplant Center Zurich, Department of Surgery,University Hospital Zurich,Zurich,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Toso","sequence":"additional","affiliation":[{"name":"Division of Abdominal and Transplantation Surgery,Hepato\u2010pancreato\u2010biliary Centre, Geneva University Hospitals,Geneva,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Majno","sequence":"additional","affiliation":[{"name":"Division of Abdominal and Transplantation Surgery,Hepato\u2010pancreato\u2010biliary Centre, Geneva University Hospitals,Geneva,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Kneteman","sequence":"additional","affiliation":[{"name":"Division of Transplantation, Department of Surgery,University of Alberta,Edmonton,Alberta,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Saunders","sequence":"additional","affiliation":[{"name":"Division of Transplantation, Department of Surgery,University of Alberta,Edmonton,Alberta,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bruix","sequence":"additional","affiliation":[{"name":"Barcelona Cl\u00ednic Liver Cancer Group, Liver Unit, Institut d'Investigacions Biom\u00e8diques, August Pi i Sunyer (IDIBAPS),Hospital Cl\u00ednic Barcelona, CIBERehd,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the iCCA International Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,8,24]]},"reference":[{"key":"hep28744-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1055\/s-2004-828889","article-title":"The epidemiology of cholangiocarcinoma","volume":"24","year":"2004","journal-title":"Semin Liver Dis"},{"key":"hep28744-bib-0002-20241017","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jhep.2012.02.022","article-title":"Are common factors involved in the pathogenesis of primary liver cancers? A meta\u2010analysis of risk factors for intrahepatic cholangiocarcinoma","volume":"57","year":"2012","journal-title":"J Hepatol"},{"key":"hep28744-bib-0003-20241017","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1016\/S0140-6736(13)61903-0","article-title":"Cholangiocarcinoma","volume":"383","year":"2014","journal-title":"Lancet"},{"key":"hep28744-bib-0004-20241017","first-page":"1245","article-title":"Hepatocellular carcinoma","volume":"31","year":"2012","journal-title":"Lancet"},{"key":"hep28744-bib-0005-20241017","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1056\/NEJM199603143341104","article-title":"Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis","volume":"334","year":"1996","journal-title":"N Engl J Med"},{"key":"hep28744-bib-0006-20241017","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/01.sla.0000108702.45715.81","article-title":"Spanish experience in liver transplantation for hilar and peripheral cholangiocarcinoma","volume":"239","year":"2004","journal-title":"Ann Surg"},{"key":"hep28744-bib-0007-20241017","first-page":"1633","article-title":"Liver transplantation for cholangiocarcinoma: results in 207 patients","volume":"69","year":"2000","journal-title":"Transplantation"},{"key":"hep28744-bib-0008-20241017","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1097\/SLA.0000000000000494","article-title":"Intrahepatic cholangiocarcinoma or mixed hepatocellular\u2010cholangiocarcinoma in patients undergoing liver transplantation: matched cohort multicenter study","volume":"259","year":"2014","journal-title":"Ann Surg"},{"key":"hep28744-bib-0009-20241017","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/ajt.12591","article-title":"Very early\u201d intrahepatic cholangiocarcinoma in cirrhotic patients: should liver transplantation be considered in these patients?","volume":"14","year":"2014","journal-title":"Am J Transplant"},{"key":"hep28744-bib-0010-20241017","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1111\/j.1600-6143.2007.01965.x","article-title":"Liver transplantation for hepatocellular carcinoma: validation of the UCSF\u2010expanded criteria based on preoperative imaging","volume":"7","year":"2007","journal-title":"Am J Transplant"},{"key":"hep28744-bib-0012-20241017","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/ctr.12108","article-title":"Unrecognized intrahepatic cholangiocarcinoma: an analysis of 993 adult cirrhotic liver explants","volume":"27","year":"2013","journal-title":"Clin Transplant"},{"key":"hep28744-bib-0013-20241017","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1159\/000332827","article-title":"The role of liver transplantation for intrahepatic cholangiocarcinoma: a single\u2010center experience","volume":"47","year":"2011","journal-title":"Eur Surg Res"},{"key":"hep28744-bib-0014-20241017","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/lt.22462","article-title":"Impact of neoadjuvant chemoradiation on the tumor burden before liver transplantation for unresectable cholangiocarcinoma","volume":"18","year":"2012","journal-title":"Liver Transpl"},{"key":"hep28744-bib-0015-20241017","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/TP.0000000000000286","article-title":"Tumors with intrahepatic bile duct differentiation in cirrhosis: implications on outcomes alter liver transplantation","volume":"99","year":"2015","journal-title":"Transplantation"},{"key":"hep28744-bib-0016-20241017","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/lt.22307","article-title":"Mixed hepatocellular cholangiocarcinoma and intrahepatic cholangiocarcinoma in patients undergoing transplantation for hepatocellular carcinoma","volume":"17","year":"2011","journal-title":"Liver Transpl"},{"key":"hep28744-bib-0017-20241017","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1016\/S1470-2045(11)70175-9","article-title":"Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report","volume":"13","year":"2012","journal-title":"Lancet Oncol"},{"key":"hep28744-bib-0018-20241017","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/j.1600-6143.2007.02138.x","article-title":"A novel model measuring the harm of transplanting hepatocellular carcinoma exceeding Milan criteria","volume":"8","year":"2008","journal-title":"Am J Transplant"},{"key":"hep28744-bib-0019-20241017","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jamcollsurg.2015.04.009","article-title":"Outcomes after resection of intrahepatic cholangiocarcinoma: external validation and comparison of prognostic models","volume":"221","year":"2015","journal-title":"J Am Coll Surg"},{"key":"hep28744-bib-0020-20241017","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1001\/jamasurg.2015.0219","article-title":"Conditional probability of long\u2010term survival after liver resection for intrahepatic cholangiocarcinoma: a multi\u2010institutional analysis of 535 patients","volume":"150","year":"2015","journal-title":"JAMA Surg"},{"key":"hep28744-bib-0021-20241017","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1245\/s10434-008-0081-1","article-title":"Influence of hepatic resection margin on recurrence and survival in intrahepatic cholangiocarcinoma","volume":"15","year":"2008","journal-title":"Ann Surg Oncol"},{"key":"hep28744-bib-0022-20241017","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/cncr.29686","article-title":"Proposal of a new staging system for intrahepatic cholangiocarcinoma: analysis of surgical patients from a nationwide survey of the Liver Cancer Study Group of Japan","volume":"122","year":"2016","journal-title":"Cancer"},{"key":"hep28744-bib-0023-20241017","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.jhep.2014.01.021","article-title":"Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma","volume":"60","year":"2014","journal-title":"J Hepatol"},{"key":"hep28744-bib-0024-20241017","doi-asserted-by":"crossref","first-page":"W205","DOI":"10.2214\/AJR.10.4937","article-title":"Radiofrequency ablation for the treatment of primary intrahepatic cholangiocarcinoma","volume":"196","year":"2011","journal-title":"AJR Am J Roentgenol"},{"key":"hep28744-bib-0025-20241017","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.jvir.2015.02.024","article-title":"Radiofrequency ablation in the treatment of unresectable intrahepatic cholangiocarcinoma: systematic review and meta\u2010analysis","volume":"26","year":"2015","journal-title":"J Vasc Interv Radiol"},{"key":"hep28744-bib-0026-20241017","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.jvir.2012.01.081","article-title":"Radiofrequency ablation in the management of unresectable intrahepatic cholangiocarcinoma","volume":"23","year":"2012","journal-title":"J Vasc Interv Radiol"},{"key":"hep28744-bib-0027-20241017","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/1097-0142(19850101)55:1<124::AID-CNCR2820550120>3.0.CO;2-Z","article-title":"Combined hepatocellular\u2010cholangiocarcinoma. A histologic and immunohistochemical study","volume":"55","year":"1985","journal-title":"Cancer"},{"key":"hep28744-bib-0028-20241017","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1002\/hep.23600","article-title":"Intrahepatic peripheral cholangiocarcinoma in cirrhosis patients may display a vascular pattern similar to hepatocellular carcinoma on contrast\u2010enhanced ultrasound","volume":"51","year":"2010","journal-title":"Hepatology"},{"key":"hep28744-bib-0029-20241017","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/hep.24199","article-title":"Management of hepatocellular carcinoma: an update","volume":"53","year":"2011","journal-title":"Hepatology"},{"key":"hep28744-bib-0030-20241017","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1477-2574.2012.00489.x","article-title":"Lymphovascular and perineural invasion as selection criteria for adjuvant therapy in intrahepatic cholangiocarcinoma: a multi\u2010institution analysis","volume":"14","year":"2012","journal-title":"HPB (Oxford)"},{"key":"hep28744-bib-0031-20241017","article-title":"The extended Toronto criteria for liver transplantation in patients with hepatocellular carcinoma: a prospective validation study","year":"2016","journal-title":"Hepatology"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.28744","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.28744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-201610000-00023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T20:24:35Z","timestamp":1729196675000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-201610000-00023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,24]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.28744","relation":{},"ISSN":["0270-9139","1527-3350"],"issn-type":[{"value":"0270-9139","type":"print"},{"value":"1527-3350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,24]]},"assertion":[{"value":"2016-03-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}