{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:05:15Z","timestamp":1792670715909,"version":"4.5.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>\n                    In patients with compensated advanced chronic liver disease (cACLD), the presence of clinically significant portal hypertension (CSPH) and varices needing treatment (VNT) bears prognostic and therapeutic implications. Our aim was to develop noninvasive tests\u2010based risk prediction models to provide a point\u2010of\u2010care risk assessment of cACLD patients. We analyzed 518 patients with cACLD from five centers in Europe\/Canada with paired noninvasive tests (liver stiffness measurement [LSM] by transient elastography, platelet count, and spleen diameter with calculation of liver stiffness to spleen\/platelet score [LSPS] score and platelet\u2010spleen ratio [PSR]) and endoscopy\/hepatic venous pressure gradient measurement. Risk of CSPH, varices, and VNT was modeled with logistic regression. All noninvasive tests reliably identified patients with high risk of CSPH, and LSPS had the highest discrimination. LSPS values above 2.65 were associated with risks of CSPH above 80%. None of the tests identified patients with very low risk of all\u2010size varices, but both LSPS and a model combining TE and platelet count identified patients with very low risk (&lt;5%) risk of VNT, suggesting that they could be used to triage patients requiring screening endoscopy. LSPS values of &lt;1.33 were associated with a &lt;5% risk of VNT, and 26% of patients had values below this threshold. LSM combined with platelet count predicted a risk &lt;5% of VNT in 30% of the patients. Nomograms were developed to facilitate point\u2010of\u2010care risk assessment.\n                    <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>\n                    : A significant proportion of patients with a very high risk of CSPH, and a population with a very low risk of VNT can be identified with simple, noninvasive tests, suggesting that these can be used to individualize medical care. (H\n                    <jats:sc>epatology<\/jats:sc>\n                    2016;64:2173\u20102184).\n                  <\/jats:p>","DOI":"10.1002\/hep.28824","type":"journal-article","created":{"date-parts":[[2016,9,17]],"date-time":"2016-09-17T11:19:07Z","timestamp":1474111147000},"page":"2173-2184","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":358,"title":["Noninvasive tools and risk of clinically significant portal hypertension and varices in compensated cirrhosis: The \u201cAnticipate\u201d study"],"prefix":"10.1097","volume":"64","author":[{"given":"Juan G.","family":"Abraldes","sequence":"first","affiliation":[{"name":"Cirrhosis Care Clinic, Division of Gastroenterology (Liver Unit),University of Alberta,CEGIIR,Edmonton,Alberta,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Bureau","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9pato\u2010gastroent\u00e9rologie H\u00f4pital Purpan CHU Toulouse,Toulouse France et Universit\u00e9 Paul Sabatier,Toulouse,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horia","family":"Stefanescu","sequence":"additional","affiliation":[{"name":"Hepatology Unit,Regional Institute of Gastroenterology and Hepatology \u201cOctavian Fodor\u201d; University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d,Cluj\u2010Napoca,Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Augustin","sequence":"additional","affiliation":[{"name":"Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d'Hebron, Institut de Recerca Vall d'Hebron (VHIR),Universitat Aut\u00f2noma de Barcelona,CIBEREHD,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ney","sequence":"additional","affiliation":[{"name":"Cirrhosis Care Clinic, Division of Gastroenterology (Liver 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Barcelona,CIBEREHD,Barcelona,Spain"},{"name":"Hepatology, Swiss Liver Center, Universit\u00e4tsklinik f\u00fcr Viszerale Chirurgie und Medizin (UVCM), Inselspital,University of Bern,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0831-8422","authenticated-orcid":false,"given":"Joan","family":"Genesca","sequence":"additional","affiliation":[{"name":"Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d'Hebron, Institut de Recerca Vall d'Hebron (VHIR),Universitat Aut\u00f2noma de Barcelona,CIBEREHD,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Berzigotti","sequence":"additional","affiliation":[{"name":"Hepatic Hemodynamic Lab, Liver Unit, Hospital Clinic,University of Barcelona,CIBEREHD,Barcelona,Spain"},{"name":"Hepatology, Swiss Liver Center, Universit\u00e4tsklinik f\u00fcr Viszerale Chirurgie und Medizin (UVCM), Inselspital,University of 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