{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:44:29Z","timestamp":1770065069065,"version":"3.49.0"},"reference-count":4,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T00:00:00Z","timestamp":1486080000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T00:00:00Z","timestamp":1486080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>We present a case of hepatosplenic necrotizing sarcoid granulomatosis, a variant form of \u201cclassical\u201d sarcoidosis, that became clinically apparent in the form of multiple hepatic and splenic masses mimicking malignancy. Flow cytometry of intrahepatic T cells isolated from liver biopsy led to the targeted treatment with anti\u2010tumor necrosis factor\u2010alpha, which was highly effective in inducing remission. (H<jats:sc>epatology<\/jats:sc> 2017;65:1410\u20101412)<\/jats:p>","DOI":"10.1002\/hep.28966","type":"journal-article","created":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T14:10:19Z","timestamp":1481983819000},"page":"1410-1412","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Anti\u2010TNF\u2010\u03b1 for necrotizing sarcoid granulomatosis of the liver"],"prefix":"10.1097","volume":"65","author":[{"given":"Marcial","family":"Sebode","sequence":"first","affiliation":[{"name":"1st Department of Medicine,University Medical Centre Hamburg\u2010Eppendorf,Hamburg,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f6ren","family":"Weidemann","sequence":"additional","affiliation":[{"name":"Department of Pathology,University Medical Centre Hamburg\u2010Eppendorf,Hamburg,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malte","family":"Wehmeyer","sequence":"additional","affiliation":[{"name":"1st Department of Medicine,University Medical Centre Hamburg\u2010Eppendorf,Hamburg,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ansgar W.","family":"Lohse","sequence":"additional","affiliation":[{"name":"1st Department of Medicine,University Medical Centre Hamburg\u2010Eppendorf,Hamburg,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Schramm","sequence":"additional","affiliation":[{"name":"1st Department of Medicine,University Medical Centre Hamburg\u2010Eppendorf,Hamburg,Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2017,2,3]]},"reference":[{"key":"hep28966-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"252","DOI":"10.5858\/arpa.2014-0051-RA","article-title":"Four decades of necrotizing sarcoid granulomatosis: what do we know now?","volume":"139","year":"2015","journal-title":"Arch Pathol Lab Med"},{"key":"hep28966-bib-0002-20241017","doi-asserted-by":"crossref","first-page":"164","DOI":"10.14309\/crj.2014.38","article-title":"Sarcoidosis presenting as necrotizing sarcoid granulomatosis of the liver, sclerosing cholangitis, and gastric ulcer","volume":"1","year":"2014","journal-title":"ACG Case Rep J"},{"key":"hep28966-bib-0003-20241017","first-page":"447","article-title":"Infliximab therapy for hepatic and intestinal sarcoidosis","volume":"3","year":"2007","journal-title":"Gastroenterol Hepatol"},{"key":"hep28966-bib-0004-20241017","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.semarthrit.2012.10.008","article-title":"Long term follow\u2010up of infliximab efficacy in pulmonary and extra\u2010pulmonary sarcoidosis refractory to conventional therapy","volume":"43","year":"2013","journal-title":"Semin Arthritis Rheum"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.28966","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-201704000-00034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:11:38Z","timestamp":1729210298000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-201704000-00034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,3]]},"references-count":4,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.28966","relation":{},"ISSN":["0270-9139","1527-3350"],"issn-type":[{"value":"0270-9139","type":"print"},{"value":"1527-3350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,3]]},"assertion":[{"value":"2016-08-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-16","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}