{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:57:56Z","timestamp":1790546276914,"version":"4.1.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>Metabolic diseases such as obesity and type 2 diabetes are recognized as independent risk factors for hepatocellular carcinoma (HCC). Hyperinsulinemia, a hallmark of these pathologies, is suspected to be involved in HCC development. The molecular adapter growth factor receptor binding protein 14 (Grb14) is an inhibitor of insulin receptor catalytic activity, highly expressed in the liver. To study its involvement in hepatocyte proliferation, we specifically inhibited its liver expression using a short hairpin RNA strategy in mice. Enhanced insulin signaling upon <jats:italic toggle=\"yes\">Grb14<\/jats:italic> inhibition was accompanied by a transient induction of S\u2010phase entrance by quiescent hepatocytes, indicating that Grb14 is a potent repressor of cell division. The proliferation of Grb14\u2010deficient hepatocytes was cell\u2010autonomous as it was also observed in primary cell cultures. Combined <jats:italic toggle=\"yes\">Grb14<\/jats:italic> down\u2010regulation and insulin signaling blockade using pharmacological approaches as well as genetic mouse models demonstrated that <jats:italic toggle=\"yes\">Grb14<\/jats:italic> inhibition\u2013mediated hepatocyte division involved insulin receptor activation and was mediated by the mechanistic target of rapamycin complex 1\u2013S6K pathway and the transcription factor E2F1. In order to determine a potential dysregulation in <jats:italic toggle=\"yes\">GRB14<\/jats:italic> gene expression in human pathophysiology, a collection of 85 human HCCs was investigated. This revealed a highly significant and frequent decrease in <jats:italic toggle=\"yes\">GRB14<\/jats:italic> expression in hepatic tumors when compared to adjacent nontumoral parenchyma, with 60% of the tumors exhibiting a reduced Grb14 mRNA level. <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>: Our study establishes Grb14 as a physiological repressor of insulin mitogenic action in the liver and further supports that dysregulation of insulin signaling is associated with HCC. (H<jats:sc>epatology<\/jats:sc> 2017;65:1352\u20101368).<\/jats:p>","DOI":"10.1002\/hep.28972","type":"journal-article","created":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T14:07:29Z","timestamp":1481983649000},"page":"1352-1368","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":27,"title":["Growth factor receptor binding protein 14 inhibition triggers insulin\u2010induced mouse hepatocyte proliferation and is associated with hepatocellular carcinoma"],"prefix":"10.1097","volume":"65","author":[{"given":"Lucille","family":"Morzyglod","sequence":"first","affiliation":[{"name":"Inserm, U1016,Institut Cochin,Paris,France"},{"name":"CNRS,UMR8104,Paris,France"},{"name":"Universit\u00e9 Paris Descartes,Sorbonne Paris Cit\u00e9,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Ca\u00fczac","sequence":"additional","affiliation":[{"name":"Inserm, U1016,Institut Cochin,Paris,France"},{"name":"CNRS,UMR8104,Paris,France"},{"name":"Universit\u00e9 Paris Descartes,Sorbonne Paris Cit\u00e9,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Popineau","sequence":"additional","affiliation":[{"name":"Inserm, U1016,Institut Cochin,Paris,France"},{"name":"CNRS,UMR8104,Paris,France"},{"name":"Universit\u00e9 Paris Descartes,Sorbonne Paris Cit\u00e9,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Damien","family":"Denechaud","sequence":"additional","affiliation":[{"name":"Department of Physiology,University of Lausanne,Lausanne,Switzerland"},{"name":"Center for Integrative Genomics,University of Lausanne,Lausanne,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lluis","family":"Fajas","sequence":"additional","affiliation":[{"name":"Department of Physiology,University of Lausanne,Lausanne,Switzerland"},{"name":"Center for Integrative Genomics,University of Lausanne,Lausanne,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Ragazzon","sequence":"additional","affiliation":[{"name":"Inserm, U1016,Institut Cochin,Paris,France"},{"name":"CNRS,UMR8104,Paris,France"},{"name":"Universit\u00e9 Paris Descartes,Sorbonne Paris Cit\u00e9,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Fauveau","sequence":"additional","affiliation":[{"name":"Inserm, U1016,Institut Cochin,Paris,France"},{"name":"CNRS,UMR8104,Paris,France"},{"name":"Universit\u00e9 Paris Descartes,Sorbonne Paris Cit\u00e9,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Planchais","sequence":"additional","affiliation":[{"name":"Inserm, U1016,Institut Cochin,Paris,France"},{"name":"CNRS,UMR8104,Paris,France"},{"name":"Universit\u00e9 Paris Descartes,Sorbonne Paris Cit\u00e9,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille","family":"Vasseur\u2010Cognet","sequence":"additional","affiliation":[{"name":"UMR IRD 242, UPEC, CNRS 7618, UPMC 113, INRA 1392, Paris,and Institut d'Ecologie et des Sciences de l'Environnement de Paris,Bondy,France"},{"name":"Sorbonne Universit\u00e9s,Paris,France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Fartoux","sequence":"additional","affiliation":[{"name":"APHP, H\u00f4pital La Piti\u00e9 Salp\u00eatri\u00e8re,Service d'H\u00e9pato\u2010Gastroent\u00e9rologie,Paris,France"},{"name":"Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, INSERM, Centre de Recherche Saint\u2010Antoine,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Scatton","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, INSERM, Centre de Recherche Saint\u2010Antoine,Paris,France"},{"name":"APHP, H\u00f4pital La Piti\u00e9\u2010Salp\u00eatri\u00e8re,Service de Chirurgie H\u00e9patobiliaire et Transplantation,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Rosmorduc","sequence":"additional","affiliation":[{"name":"APHP, H\u00f4pital La Piti\u00e9 Salp\u00eatri\u00e8re,Service d'H\u00e9pato\u2010Gastroent\u00e9rologie,Paris,France"},{"name":"Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, INSERM, Centre de Recherche Saint\u2010Antoine,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Guilmeau","sequence":"additional","affiliation":[{"name":"Inserm, U1016,Institut Cochin,Paris,France"},{"name":"CNRS,UMR8104,Paris,France"},{"name":"Universit\u00e9 Paris Descartes,Sorbonne Paris Cit\u00e9,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Postic","sequence":"additional","affiliation":[{"name":"Inserm, U1016,Institut Cochin,Paris,France"},{"name":"CNRS,UMR8104,Paris,France"},{"name":"Universit\u00e9 Paris Descartes,Sorbonne Paris Cit\u00e9,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Desdouets","sequence":"additional","affiliation":[{"name":"Inserm, U1016,Institut Cochin,Paris,France"},{"name":"CNRS,UMR8104,Paris,France"},{"name":"Universit\u00e9 Paris Descartes,Sorbonne Paris Cit\u00e9,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christ\u00e8le","family":"Desbois\u2010Mouthon","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, INSERM, Centre de Recherche Saint\u2010Antoine,Paris,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Fran\u00e7oise","family":"Burnol","sequence":"additional","affiliation":[{"name":"Inserm, U1016,Institut Cochin,Paris,France"},{"name":"CNRS,UMR8104,Paris,France"},{"name":"Universit\u00e9 Paris Descartes,Sorbonne Paris Cit\u00e9,France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"hep28972-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/414799a","article-title":"Insulin signalling and the regulation of glucose and lipid metabolism","volume":"414","year":"2001","journal-title":"Nature"},{"key":"hep28972-bib-0002-20241017","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.tem.2010.06.007","article-title":"The proliferating role of insulin and insulin\u2010like growth factors in cancer","volume":"21","year":"2010","journal-title":"Trends Endocrinol Metab"},{"key":"hep28972-bib-0003-20241017","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1152\/physrev.00030.2014","article-title":"Obesity and diabetes: the increased risk of cancer and cancer\u2010related mortality","volume":"95","year":"2015","journal-title":"Physiol Rev"},{"key":"hep28972-bib-0004-20241017","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1111\/liv.12903","article-title":"Hyperinsulinaemia and insulin signalling in the pathogenesis and the clinical course of hepatocellular carcinoma","volume":"35","year":"2015","journal-title":"Liver Int"},{"key":"hep28972-bib-0005-20241017","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/pros.20852","article-title":"Insulin receptor expression by human prostate cancers","volume":"69","year":"2009","journal-title":"Prostate"},{"key":"hep28972-bib-0006-20241017","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.1158\/0008-5472.CAN-12-3824","article-title":"Mitogenic insulin receptor\u2010A is overexpressed in human hepatocellular carcinoma due to EGFR\u2010mediated dysregulation of RNA splicing factors","volume":"73","year":"2013","journal-title":"Cancer Res"},{"key":"hep28972-bib-0007-20241017","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1210\/er.2008-0047","article-title":"Insulin receptor isoforms and insulin receptor\/insulin\u2010like growth factor receptor hybrids in physiology and disease","volume":"30","year":"2009","journal-title":"Endocr Rev"},{"key":"hep28972-bib-0008-20241017","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1042\/BJ20080279","article-title":"Activation of the insulin receptor (IR) by insulin and a synthetic peptide has different effects on gene expression in IR\u2010transfected L6 myoblasts","volume":"412","year":"2008","journal-title":"Biochem J"},{"key":"hep28972-bib-0009-20241017","article-title":"Insulin receptor signaling in normal and insulin\u2010resistant states","volume":"6","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"hep28972-bib-0010-20241017","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1002\/hep.510290632","article-title":"Insulin and insulin\u2010like growth factor\u20101 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: differential effects on signal transduction pathways","volume":"29","year":"1999","journal-title":"Hepatology"},{"key":"hep28972-bib-0011-20241017","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/1097-4652(2001)9999:9999<::AID-JCP1058>3.0.CO;2-V","article-title":"Insulin signaling leading to proliferation, survival, and membrane ruffling in C2C12 myoblasts","volume":"187","year":"2001","journal-title":"J Cell Physiol"},{"key":"hep28972-bib-0012-20241017","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/sj.emboj.7601487","article-title":"Insulin delays the progression of Drosophila cells through G2\/M by activating the dTOR\/dRaptor complex","volume":"26","year":"2007","journal-title":"EMBO J"},{"key":"hep28972-bib-0013-20241017","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/BJ20130490","article-title":"Down\u2010regulation of cyclin G2 by insulin, IGF\u2010I (insulin\u2010like growth factor 1) and X10 (AspB10 insulin): role in mitogenesis","volume":"457","year":"2014","journal-title":"Biochem J"},{"key":"hep28972-bib-0014-20241017","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/febs.12080","article-title":"Regulation of insulin and type 1 insulin\u2010like growth factor signaling and action by the Grb10\/14 and SH2B1\/B2 adaptor proteins","volume":"280","year":"2013","journal-title":"FEBS J"},{"key":"hep28972-bib-0015-20241017","doi-asserted-by":"crossref","first-page":"26026","DOI":"10.1074\/jbc.273.40.26026","article-title":"Identification of the rat adapter Grb14 as an inhibitor of insulin actions","volume":"273","year":"1998","journal-title":"J Biol Chem"},{"key":"hep28972-bib-0016-20241017","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1074\/jbc.M106574200","article-title":"Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14","volume":"277","year":"2002","journal-title":"J Biol Chem"},{"key":"hep28972-bib-0017-20241017","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1111\/j.1742-4658.2008.06583.x","article-title":"Compartmentalization and in vivo insulin\u2010induced translocation of the insulin\u2010signaling inhibitor Grb14 in rat liver","volume":"275","year":"2008","journal-title":"FEBS J"},{"key":"hep28972-bib-0018-20241017","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1210\/en.2007-1196","article-title":"Dual effect of the adapter Grb14 on insulin action in primary hepatocytes","volume":"149","year":"2008","journal-title":"Endocrinology"},{"key":"hep28972-bib-0019-20241017","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1210\/me.2008-0360","article-title":"Molecular determinants of Grb14\u2010mediated inhibition of insulin signaling","volume":"23","year":"2009","journal-title":"Mol Endocrinol"},{"key":"hep28972-bib-0020-20241017","doi-asserted-by":"crossref","first-page":"8283","DOI":"10.1038\/ncomms9283","article-title":"Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling","volume":"6","year":"2015","journal-title":"Nat Commun"},{"key":"hep28972-bib-0021-20241017","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1128\/MCB.24.8.3112-3124.2004","article-title":"S6K1\u2013\/\u2013\/S6K2\u2013\/\u2013 mice exhibit perinatal lethality and rapamycin\u2010sensitive 5\u2032\u2010terminal oligopyrimidine mRNA translation and reveal a mitogen\u2010activated protein kinase\u2013dependent S6 kinase pathway","volume":"24","year":"2004","journal-title":"Mol Cell Biol"},{"key":"hep28972-bib-0022-20241017","doi-asserted-by":"crossref","first-page":"19095","DOI":"10.1074\/jbc.M300982200","article-title":"Liver cell polyploidization: a pivotal role for binuclear hepatocytes","volume":"278","year":"2003","journal-title":"J Biol Chem"},{"key":"hep28972-bib-0023-20241017","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1096\/fj.03-0824fje","article-title":"Increased adipose tissue expression of Grb14 in several models of insulin resistance","volume":"18","year":"2004","journal-title":"FASEB J"},{"key":"hep28972-bib-0024-20241017","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrc2399","article-title":"Cellular mechanisms of tumour suppression by the retinoblastoma gene","volume":"8","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"hep28972-bib-0025-20241017","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1084\/jem.20110198","article-title":"Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway","volume":"208","year":"2011","journal-title":"J Exp Med"},{"key":"hep28972-bib-0026-20241017","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","year":"2012","journal-title":"Cell"},{"key":"hep28972-bib-0027-20241017","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1172\/JCI35237","article-title":"Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation","volume":"118","year":"2008","journal-title":"J Clin Invest"},{"key":"hep28972-bib-0028-20241017","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ccr.2010.01.021","article-title":"Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP\u2010eIF4E","volume":"17","year":"2010","journal-title":"Cancer Cell"},{"key":"hep28972-bib-0029-20241017","doi-asserted-by":"crossref","first-page":"8421","DOI":"10.1158\/1078-0432.CCR-04-0941","article-title":"mTOR and P70 S6 kinase expression in primary liver neoplasms","volume":"10","year":"2004","journal-title":"Clin Cancer Res"},{"key":"hep28972-bib-0030-20241017","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s12032-009-9201-4","article-title":"The mTOR pathway is associated with the poor prognosis of human hepatocellular carcinoma","volume":"27","year":"2010","journal-title":"Med Oncol"},{"key":"hep28972-bib-0031-20241017","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1172\/JCI44203","article-title":"S6 kinase 1 is required for rapamycin\u2010sensitive liver proliferation after mouse hepatectomy","volume":"121","year":"2011","journal-title":"J Clin Invest"},{"key":"hep28972-bib-0032-20241017","doi-asserted-by":"crossref","first-page":"10943","DOI":"10.1074\/jbc.M007758200","article-title":"Rapamycin\u2010insensitive regulation of 4e\u2010BP1 in regenerating rat liver","volume":"276","year":"2001","journal-title":"J Biol Chem"},{"key":"hep28972-bib-0033-20241017","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/jcp.21172","article-title":"Liver regeneration","volume":"213","year":"2007","journal-title":"J Cell Physiol"},{"key":"hep28972-bib-0034-20241017","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.tcb.2008.08.003","article-title":"E2F\u2014at the crossroads of life and death","volume":"18","year":"2008","journal-title":"Trends Cell Biol"},{"key":"hep28972-bib-0035-20241017","doi-asserted-by":"crossref","first-page":"5054","DOI":"10.1038\/sj.onc.1203885","article-title":"Dual functions of E2F\u20101 in a transgenic mouse model of liver carcinogenesis","volume":"19","year":"2000","journal-title":"Oncogene"},{"key":"hep28972-bib-0036-20241017","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/hep.27121","article-title":"E2F1 is a novel fibrogenic gene that regulates cholestatic liver fibrosis through the Egr\u20101\/SHP\/EID1 network","volume":"60","year":"2014","journal-title":"Hepatology"},{"key":"hep28972-bib-0037-20241017","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1172\/JCI81542","article-title":"E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis","volume":"126","year":"2015","journal-title":"J Clin Invest"},{"key":"hep28972-bib-0038-20241017","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00428-012-1220-4","article-title":"E2F\u20101 is overexpressed and pro\u2010apoptotic in human hepatocellular carcinoma","volume":"460","year":"2012","journal-title":"Virchows Arch"},{"key":"hep28972-bib-0039-20241017","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.cellsig.2015.01.003","article-title":"Insulin\u2010induced cell division is controlled by the adaptor Grb14 in a Chfr\u2010dependent manner","volume":"27","year":"2015","journal-title":"Cell Signal"},{"key":"hep28972-bib-0040-20241017","first-page":"161","article-title":"Emerging evidence for CHFR as a cancer biomarker: from tumor biology to precision medicine","volume":"33","year":"2014","journal-title":"Cancer Metastasis Rev"},{"key":"hep28972-bib-0041-20241017","first-page":"1854","article-title":"Aberrant methylation of the CHFR gene in advanced hepatocellular carcinoma","volume":"52","year":"2005","journal-title":"Hepatogastroenterology"},{"key":"hep28972-bib-0042-20241017","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1042\/CBI20100851","article-title":"Promoter hypermethylation of DNA damage response genes in hepatocellular carcinoma","volume":"36","year":"2012","journal-title":"Cell Biol Int"},{"key":"hep28972-bib-0043-20241017","doi-asserted-by":"crossref","first-page":"6959","DOI":"10.1128\/MCB.22.20.6959-6970.2002","article-title":"The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Cz","volume":"22","year":"2002","journal-title":"Mol Cell Biol"},{"key":"hep28972-bib-0044-20241017","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1128\/MCB.00170-16","article-title":"Novel Grb14\u2010mediated cross talk between insulin and p62\/Nrf2 pathways regulates liver lipogenesis and selective insulin resistance","volume":"36","year":"2016","journal-title":"Mol Cell Biol"},{"key":"hep28972-bib-0045-20241017","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1128\/MCB.00620-10","article-title":"Phosphorylation of p62 by cdk1 controls the timely transit of cells through mitosis and tumor cell proliferation","volume":"31","year":"2011","journal-title":"Mol Cell Biol"},{"key":"hep28972-bib-0046-20241017","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/jcp.20199","article-title":"Hormonal regulation of the Grb14 signal modulator and its role in cell cycle progression of MCF\u20107 human breast cancer cells","volume":"203","year":"2005","journal-title":"J Cell Physiol"},{"key":"hep28972-bib-0047-20241017","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1093\/jjco\/hyt130","article-title":"Grb14 as an independent good prognosis factor for breast cancer patients treated with neoadjuvant chemotherapy","volume":"43","year":"2013","journal-title":"Jpn J Clin Oncol"},{"key":"hep28972-bib-0048-20241017","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge\u2010based approach for interpreting genome\u2010wide expression profiles","volume":"102","year":"2005","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.28972","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-201704000-00028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:11:35Z","timestamp":1729210295000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-201704000-00028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,21]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.28972","relation":{},"ISSN":["0270-9139","1527-3350"],"issn-type":[{"value":"0270-9139","type":"print"},{"value":"1527-3350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,21]]},"assertion":[{"value":"2016-05-13","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}