{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:23:29Z","timestamp":1792697009032,"version":"4.5.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T00:00:00Z","timestamp":1490140800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T00:00:00Z","timestamp":1490140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>\n                    Liver fibrosis is the net result of dynamic changes between fibrogenesis and fibrolysis. Evidence has shown that antiviral therapy can reverse liver fibrosis or even early cirrhosis caused by hepatitis B virus. However, current evaluation systems mainly focus on the severity of, but not the dynamic changes in, fibrosis. Here, we propose a new classification to evaluate the dynamic changes in the quality of fibrosis, namely:\n                    <jats:italic toggle=\"yes\">predominantly progressive<\/jats:italic>\n                    (thick\/broad\/loose\/pale septa with inflammation);\n                    <jats:italic toggle=\"yes\">predominately regressive<\/jats:italic>\n                    (delicate\/thin\/dense\/splitting septa); and\n                    <jats:italic toggle=\"yes\">indeterminate<\/jats:italic>\n                    , which displayed an overall balance between progressive and regressive scarring. Then, we used this classification to evaluate 71 paired liver biopsies of chronic hepatitis B patients before and after entecavir\u2010based therapy for 78 weeks.\n                    <jats:italic toggle=\"yes\">Progressive, indeterminate<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">regressive<\/jats:italic>\n                    were observed in 58%, 29%, and 13% of patients before treatment versus in 11%, 11%, and 78% after treatment. Of the 55 patients who showed predominantly regressive changes on posttreatment liver biopsy, 29 cases (53%) had fibrosis improvement of at least one Ishak stage, and, more interestingly, 25 cases (45%) had significant improvement in terms of Laennec substage, collagen percentage area, and liver stiffness despite remaining in the same Ishak stage.\n                    <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>\n                    : This new classification highlights the importance of assessing and identifying the dynamic changes in the quality of fibrosis, especially relevant in the era of antiviral therapy.(H\n                    <jats:sc>epatology<\/jats:sc>\n                    2017;65:1438\u20101450)\n                  <\/jats:p>","DOI":"10.1002\/hep.29009","type":"journal-article","created":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T19:48:48Z","timestamp":1482868128000},"page":"1438-1450","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":149,"title":["New classification of liver biopsy assessment for fibrosis in chronic hepatitis B patients before and after treatment"],"prefix":"10.1097","volume":"65","author":[{"given":"Yameng","family":"Sun","sequence":"first","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, National Clinical Research Center of Digestive Diseases,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, National Clinical Research Center of Digestive Diseases,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, National Clinical Research Center of Digestive Diseases,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"Wu","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, National Clinical Research Center of Digestive Diseases,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongpeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxin","family":"Piao","sequence":"additional","affiliation":[{"name":"Infectious Department,Affiliated Hospital of Yanbian University,Yanji,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lungen","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongshan Hospital,Fudan University,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Digestive System, Beijing Tiantan Hospital,Capital Medical University,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Feng","sequence":"additional","affiliation":[{"name":"Hepatology Institute,Peking University People's Hospital,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuemin","family":"Nan","sequence":"additional","affiliation":[{"name":"Department of Traditional and Western Medical Hepatology,Third Hospital of Hebei Medical University,Shijiazhuang,Hebei,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Xie","sequence":"additional","affiliation":[{"name":"Center of Liver Diseases, Beijing Ditan Hospital,Capital Medical University,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Second Liver Cirrhosis Diagnosis and Treatment Center, 302 Military Hospital of China,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanwei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease,the Fifth Hospital of Shijiazhuang City,Shijiazhuang,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary and Splenic Medicine, Affiliated Hospital,Logistics University of People's Armed Police Force,Tianjin,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiguo","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Beijing Youan Hospital,Capital Medical University,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beijing Youan Hospital,Capital Medical University,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fudong","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beijing Youan Hospital,Capital Medical University,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Pathology,China\u2010Japan Friendship Hospital,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tailing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology,China\u2010Japan Friendship Hospital,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Ou","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, National Clinical Research Center of Digestive Diseases,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqiong","family":"Wang","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, National Clinical Research Center of Digestive Diseases,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis, National Clinical Research Center of Digestive Diseases,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aileen","family":"Wee","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yong Loo Lin School of Medicine,National University of Singapore, National University 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