{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:20:21Z","timestamp":1790713221074,"version":"4.1.0"},"reference-count":72,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T00:00:00Z","timestamp":1501113600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T00:00:00Z","timestamp":1501113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Selective internal radiation therapy (or radioembolization) by intra\u2010arterial injection of radioactive yttrium\u201090\u2010loaded microspheres is increasingly used for the treatment of patients with liver metastases or primary liver cancer. The high\u2010dose beta\u2010radiation penetrates an average of only 2.5 mm from the source, thus limiting its effects to the site of delivery. However, the off\u2010target diversion of yttrium\u201090 microspheres to tissues other than the tumor may lead to complications. The most prominent of these complications include radiation gastritis and gastrointestinal ulcers, cholecystitis, radiation pneumonitis, and radioembolization\u2010induced liver disease, which may occur despite careful pretreatment planning. Thus, selective internal radiation therapy demands an expert multidisciplinary team approach in order to provide comprehensive care for patients. This review provides recommendations to multidisciplinary teams on the optimal medical processes in order to ensure the safe delivery of selective internal radiation therapy. Based on the best available published evidence and expert opinion, we recommend the most appropriate strategies for the prevention, early diagnosis, and management of potential radiation injury to the liver and to other organs. (H<jats:sc>epatology<\/jats:sc> 2017;66:969\u2013982).<\/jats:p>","DOI":"10.1002\/hep.29207","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T18:29:55Z","timestamp":1492108195000},"page":"969-982","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":118,"title":["Prevention and treatment of complications of selective internal radiation therapy: Expert guidance and systematic review"],"prefix":"10.1097","volume":"66","author":[{"given":"Bruno","family":"Sangro","sequence":"first","affiliation":[{"name":"Liver Unit,Clinica Universidad de Navarra and Instituto de Investigaci\u00f3n Sanitaria de Navarra,Pamplona,Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas,Pamplona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Mart\u00ednez\u2010Urbistondo","sequence":"additional","affiliation":[{"name":"Liver Unit,Clinica Universidad de Navarra and Instituto de Investigaci\u00f3n Sanitaria de Navarra,Pamplona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourens","family":"Bester","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology,University of New South Wales St. Vincent's Hospital,Darlinghurst,Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose I.","family":"Bilbao","sequence":"additional","affiliation":[{"name":"Department of Radiology,Cl\u00ednica Universidad de Navarra and Instituto de Investigaci\u00f3n Sanitaria de Navarra,Pamplona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas M.","family":"Coldwell","sequence":"additional","affiliation":[{"name":"James Graham Brown Cancer 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