{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:46:01Z","timestamp":1792759561451,"version":"4.5.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T00:00:00Z","timestamp":1500336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T00:00:00Z","timestamp":1500336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Acute\u2010on\u2010chronic liver injury is characterized by an important inflammatory response frequently associated with endotoxemia. In this context, acute\u2010phase proteins such as Pentraxin\u20103 (PTX3) are released; however, little is known about their role in chronic liver disease. The aim of this study was to elucidate the role of PTX3 in liver injury. The role of PTX3 was evaluated in cultured human cells, liver tissue slices, and mice with acute\u2010on\u2010chronic liver injury. PTX3 expression was assessed in tissue and serum samples from 54 patients with alcoholic hepatitis. PTX3 expression was up\u2010regulated in animal models of liver injury and strongly induced by lipopolysaccharide (LPS). Liver cell fractionation showed that macrophages and activated hepatic stellate cells were the main cell types expressing PTX3 in liver injury. <jats:italic toggle=\"yes\">Ex vivo<\/jats:italic> and <jats:italic toggle=\"yes\">in vivo<\/jats:italic> studies showed that PTX3 treatment attenuated LPS\u2010induced liver injury, inflammation, and cell recruitment. Mechanistically, PTX3 mediated the hepatic stellate cell wound\u2010healing response. Moreover, PTX3 modulated LPS\u2010induced inflammation in human primary liver macrophages and peripheral monocytes by enhancing a TIR domain\u2013containing adapter\u2010inducing interferon\u2013dependent response and favoring a macrophage interleukin\u201010\u2010like phenotype. Additionally, hepatic and plasma PTX3 levels were increased in patients with alcoholic hepatitis, a prototypic acute\u2010on\u2010chronic condition; and its expression correlated with disease severity scores, endotoxemia, infections, and short\u2010term mortality, thus suggesting that expression of PTX3 found in patients could be a counterregulatory response to injury. <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>: Experimental and human evidence suggests that, in addition to being a potential biomarker for alcoholic hepatitis, PTX3 participates in the wound\u2010healing response and attenuates LPS\u2010induced liver injury and inflammation; therefore, administration of PTX3 could be a promising therapeutic strategy in acute\u2010on\u2010chronic conditions, particularly those associated with endotoxemia. (H<jats:sc>epatology<\/jats:sc> 2017;66:953\u2013968).<\/jats:p>","DOI":"10.1002\/hep.29215","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T10:33:33Z","timestamp":1492598013000},"page":"953-968","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":48,"title":["Pentraxin\u20103 modulates lipopolysaccharide\u2010induced inflammatory response and attenuates liver injury"],"prefix":"10.1097","volume":"66","author":[{"given":"Luis","family":"Perea","sequence":"first","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Coll","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS),Barcelona,Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y 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(VUB),Brussels,Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rodrigo\u2010Torres","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Altamirano","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Graupera","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS),Barcelona,Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas 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Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd),Barcelona,Spain"},{"name":"Liver Unit, Hospital Cl\u00ednic, Faculty of Medicine,University of Barcelona,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0990-7034","authenticated-orcid":false,"given":"Leo A.","family":"van Grunsven","sequence":"additional","affiliation":[{"name":"Liver Cell Biology Lab, Faculty of Medicine and Pharmacy,Vrije Universiteit Brussel (VUB),Brussels,Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u2010Rosa","family":"Sarrias","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd),Barcelona,Spain"},{"name":"Innate Immunity Group,Health Sciences Research Institute Germans Trias i Pujol,Badalona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pere","family":"Gin\u00e8s","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS),Barcelona,Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd),Barcelona,Spain"},{"name":"Liver Unit, Hospital Cl\u00ednic, Faculty of Medicine,University of Barcelona,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau","family":"Sancho\u2010Bru","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS),Barcelona,Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas 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