{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:07:21Z","timestamp":1793502441472,"version":"4.5.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T00:00:00Z","timestamp":1509926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T00:00:00Z","timestamp":1509926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>\n                    Cardiovascular disease (CVD) complications are important causes of morbidity and mortality after orthotopic liver transplantation (OLT). There is currently no preoperative risk\u2010assessment tool that allows physicians to estimate the risk for CVD events following OLT. We sought to develop a point\u2010based prediction model (risk score) for CVD complications after OLT, the Cardiovascular Risk in Orthotopic Liver Transplantation risk score, among a cohort of 1,024 consecutive patients aged 18\u201075 years who underwent first OLT in a tertiary\u2010care teaching hospital (2002\u20102011). The main outcome measures were major 1\u2010year CVD complications, defined as death from a CVD cause or hospitalization for a major CVD event (myocardial infarction, revascularization, heart failure, atrial fibrillation, cardiac arrest, pulmonary embolism, and\/or stroke). The bootstrap method yielded bias\u2010corrected 95% confidence intervals for the regression coefficients of the final model. Among 1,024 first OLT recipients, major CVD complications occurred in 329 (32.1%). Variables selected for inclusion in the model (using model optimization strategies) included preoperative recipient age, sex, race, employment status, education status, history of hepatocellular carcinoma, diabetes, heart failure, atrial fibrillation, pulmonary or systemic hypertension, and respiratory failure. The discriminative performance of the point\u2010based score (C statistic = 0.78, bias\u2010corrected C statistic = 0.77) was superior to other published risk models for postoperative CVD morbidity and mortality, and it had appropriate calibration (Hosmer\u2010Lemeshow\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.33).\n                    <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    The point\u2010based risk score can identify patients at risk for CVD complications after OLT surgery (available at www.carolt.us); this score may be useful for identification of candidates for further risk stratification or other management strategies to improve CVD outcomes after OLT. (H\n                    <jats:sc>epatology<\/jats:sc>\n                    2017;66:1968\u20131979)\n                  <\/jats:p>","DOI":"10.1002\/hep.29329","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T09:09:26Z","timestamp":1499936966000},"page":"1968-1979","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":121,"title":["A point\u2010based prediction model for cardiovascular risk in orthotopic liver transplantation: The CAR\u2010OLT score"],"prefix":"10.1097","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6264-2573","authenticated-orcid":false,"given":"Lisa B.","family":"VanWagner","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology & Hepatology,Northwestern University Feinberg School of Medicine,Chicago,IL"},{"name":"Department of Preventive Medicine,Northwestern University Feinberg School of Medicine,Chicago,IL"},{"name":"Northwestern University Transplant Outcomes Research Collaborative,Northwestern University Feinberg School of Medicine,Chicago,IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine,Northwestern University Feinberg School of Medicine,Chicago,IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Whitsett","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology & Hepatology,Northwestern University Feinberg School of Medicine,Chicago,IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh","family":"Levitsky","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology & Hepatology,Northwestern University Feinberg School of Medicine,Chicago,IL"},{"name":"Northwestern University Transplant Outcomes Research Collaborative,Northwestern University Feinberg School of Medicine,Chicago,IL"},{"name":"Department of Surgery, Division of Organ Transplantation,Northwestern University Feinberg School of Medicine,Chicago,IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Uttal","sequence":"additional","affiliation":[{"name":"Northwestern University Transplant Outcomes Research Collaborative,Northwestern University Feinberg School of Medicine,Chicago,IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Wilkins","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine,Northwestern University Feinberg School of Medicine,Chicago,IL"},{"name":"Department of Medicine, Division of Cardiology,Northwestern University Feinberg School of Medicine,Chicago,IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Abecassis","sequence":"additional","affiliation":[{"name":"Northwestern University Transplant Outcomes Research Collaborative,Northwestern University Feinberg School of Medicine,Chicago,IL"},{"name":"Department of Surgery, Division of Organ Transplantation,Northwestern University Feinberg School of Medicine,Chicago,IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela P.","family":"Ladner","sequence":"additional","affiliation":[{"name":"Northwestern University Transplant Outcomes Research Collaborative,Northwestern University Feinberg School of Medicine,Chicago,IL"},{"name":"Department of Surgery, Division of Organ Transplantation,Northwestern University Feinberg School of Medicine,Chicago,IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton I.","family":"Skaro","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of General Surgery and Multi\u2010Organ Transplant,University of Western Ontario Schulich School of Medicine & Dentistry,London,ON,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M.","family":"Lloyd\u2010Jones","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine,Northwestern University Feinberg School of Medicine,Chicago,IL"},{"name":"Department of Medicine, Division of Cardiology,Northwestern University Feinberg School of Medicine,Chicago,IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,11,6]]},"reference":[{"key":"hep29329-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/lt.23950","article-title":"High early cardiovascular mortality after liver transplantation","volume":"20","year":"2014","journal-title":"Liver Transpl"},{"key":"hep29329-bib-0002-20241017","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/lt.24137","article-title":"Cardiovascular disease after liver transplantation: when, what, and who is at 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