{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:23:01Z","timestamp":1792513381869,"version":"4.5.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>Patients with compensated advanced chronic liver disease (cACLD) can safely avoid screening endoscopy with a platelet count &gt;150 \u00d7 10<jats:sup>9<\/jats:sup>cells\/L and a liver stiffness measurement (LSM) &lt;20 kPa (Baveno VI criteria). However, the total number of avoided endoscopies using this rule is relatively low. We aimed at expanding the Baveno VI criteria and validating them in additional cohorts. Patients from the Anticipate cohort (499 patients with cACLD of different etiologies) were used to study the performance of different thresholds of platelets and LSM for the identification of patients at very low risk (&lt;5%) of having varices needing treatment (VNT). The new criteria (Expanded\u2010Baveno VI) were validated in two additional cohorts from London (309 patients) and Barcelona (117 patients). The performance of the new criteria by etiology of cACLD was also assessed. The best new expanded classification rule was platelet count &gt;110 \u00d7 10<jats:sup>9<\/jats:sup>cells\/L and LSM &lt;25 kPa. This was validated in the two additional cohorts. Overall, the Expanded\u2010Baveno VI criteria would potentially spare 367 (40%) endoscopies (21% with Baveno VI criteria) with a risk of missing VNT of 1.6% (95% confidence interval, 0.7%\u20103.5%) in patients within the criteria and 0.6% (95% confidence interval, 0.3%\u20101.4%) in the overall population of 925 patients evaluated. The Expanded\u2010Baveno VI criteria performed well in patients with cACLD with hepatitis C virus and alcoholic and nonalcoholic steatohepatitis.<jats:italic toggle=\"yes\">Conclusion<\/jats:italic>: The new Expanded\u2010Baveno VI criteria spare more endoscopies than the original criteria with a minimal risk of missing VNT in most of the main etiologies of cACLD. (H<jats:sc>epatology<\/jats:sc>2017;66:1980\u20131988)<\/jats:p>","DOI":"10.1002\/hep.29363","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T13:07:01Z","timestamp":1499778421000},"page":"1980-1988","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":249,"title":["Expanding the Baveno VI criteria for the screening of varices in patients with compensated advanced chronic liver disease"],"prefix":"10.1097","volume":"66","author":[{"given":"Salvador","family":"Augustin","sequence":"first","affiliation":[{"name":"Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d'Hebron, Institut de Recerca Vall d'Hebron,Universitat Aut\u00f2noma de Barcelona,Barcelona,Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas,Instituto de Salud Carlos III,Madrid,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f2nica","family":"Pons","sequence":"additional","affiliation":[{"name":"Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d'Hebron, Institut de Recerca Vall d'Hebron,Universitat Aut\u00f2noma de Barcelona,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Maurice","sequence":"additional","affiliation":[{"name":"Department of Hepatology,Imperial College Healthcare NHS Trust,London,United Kingdom"},{"name":"University College London, Institute for Liver and Digestive Health,Royal Free Hospital and University College London,London,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Bureau","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9pato\u2010gastroent\u00e9rologie H\u00f4pital Purpan CHU Toulouse,Universit\u00e9 Paul Sabatier,Toulouse,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horia","family":"Stefanescu","sequence":"additional","affiliation":[{"name":"Hepatology Unit, Regional Institute of Gastroenterology and Hepatology \u201cOctavian Fodor\u201d,University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d,Cluj\u2010Napoca,Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Ney","sequence":"additional","affiliation":[{"name":"Cirrhosis Care Clinic, Division of Gastroenterology (Liver Unit),University of Alberta, Centre of Excellence for Gastrointestinal Inflammation and Immunity Research,Edmonton,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Blasco","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9pato\u2010gastroent\u00e9rologie H\u00f4pital Purpan CHU Toulouse,Universit\u00e9 Paul Sabatier,Toulouse,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Procopet","sequence":"additional","affiliation":[{"name":"Hepatology Unit, Regional Institute of Gastroenterology and Hepatology \u201cOctavian Fodor\u201d,University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d,Cluj\u2010Napoca,Romania"},{"name":"Hepatic Hemodynamic Lab, Liver Unit, Hospital Clinic,University of Barcelona,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5069-2461","authenticated-orcid":false,"given":"Emmanuel","family":"Tsochatzis","sequence":"additional","affiliation":[{"name":"University College London, Institute for Liver and Digestive Health,Royal Free Hospital and University College London,London,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel H.","family":"Westbrook","sequence":"additional","affiliation":[{"name":"University College London, Institute for Liver and Digestive Health,Royal Free Hospital and University College London,London,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Bosch","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas,Instituto de Salud Carlos III,Madrid,Spain"},{"name":"Hepatic Hemodynamic Lab, Liver Unit, Hospital Clinic,University of Barcelona,Barcelona,Spain"},{"name":"Swiss Liver Center, Hepatology, University Clinic for Visceral Surgery and Medicine, Inselspital,University of Bern,Bern,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Berzigotti","sequence":"additional","affiliation":[{"name":"Hepatic Hemodynamic Lab, Liver Unit, Hospital Clinic,University of Barcelona,Barcelona,Spain"},{"name":"Swiss Liver Center, Hepatology, University Clinic for Visceral Surgery and Medicine, Inselspital,University of 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