{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:41:38Z","timestamp":1782826898109,"version":"3.54.5"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>The salvage liver transplantation (SLT) strategy was conceived for initially resectable and transplantable (R&amp;T) hepatocellular carcinoma (HCC) patients, to try to obviate upfront liver transplantation, with the \u201csafety net\u201d of SLT in case of postresection recurrence. The SLT strategy is successful or curative when patients are recurrence free following primary resection alone, or after SLT for recurrence. The aim of the current study was to determine the SLT strategy's potential for cure in R&amp;T HCC patients, and to identify predictors for its success. From 1994 to 2012, all R&amp;T HCC patients with cirrhosis were enrolled in the SLT strategy. An intention\u2010to\u2010treat (ITT) analysis was used to determine this strategy's outcomes and predictors of success according to the above definition. In total, 110 patients were enrolled in the SLT strategy. Sixty\u2010three patients (57%) had tumor recurrence after initial resection, and in 30 patients SLT could be performed (recurrence transplantability rate = 48%). From the time of initial resection, ITT 5\u2010year overall and disease\u2010free survival rates were 69% and 60%, respectively. The SLT strategy was successful in 60 patients (56%), either by resection alone (36%), or by SLT for recurrence (19%). Preresection predictors of successful SLT strategy at multivariate analysis included Model for End\u2010Stage Liver Disease (MELD) score &gt;10, and absence of neoadjuvant transarterial chemoembolization (TACE). Additional postresection predictive factors were absence of postresection morbidity, and T\u2010stage 1\u20102 at the resection specimen. <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> The SLT strategy is curative in only 56% of cases. Higher MELD score at inception of the strategy and no pre\u2010resection TACE are predictors of successful SLT strategy. (H<jats:sc>epatology<\/jats:sc> 2018;67:204\u2010215).<\/jats:p>","DOI":"10.1002\/hep.29468","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T16:12:41Z","timestamp":1502727161000},"page":"204-215","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":55,"title":["Curative salvage liver transplantation in patients with cirrhosis and hepatocellular carcinoma: An intention\u2010to\u2010treat analysis"],"prefix":"10.1097","volume":"67","author":[{"given":"Robbert J.","family":"de Haas","sequence":"first","affiliation":[{"name":"Medical Imaging Department, Henri Mondor Hospital,Assistance Publique\u2010H\u00f4pitaux de Paris-Universit\u00e9 Paris-Est,Cr\u00e9teil,France"},{"name":"Department of Radiology, Medical Imaging Center Groningen,University Medical Center Groningen,Groningen,The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9644-2572","authenticated-orcid":false,"given":"Chetana","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Pancreato\u2010Biliary Surgery and Liver Transplantation, Henri Mondor Hospital,Assistance Publique\u2010H\u00f4pitaux de Paris\u2010Universit\u00e9 Paris\u2010Est,Cr\u00e9teil,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Bhangui","sequence":"additional","affiliation":[{"name":"Medanta Institute of Liver Transplantation and Regenerative Medicine,Medanta The Medicity,New Delhi,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chady","family":"Salloum","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Pancreato\u2010Biliary Surgery and Liver Transplantation, Henri Mondor Hospital,Assistance Publique\u2010H\u00f4pitaux de Paris\u2010Universit\u00e9 Paris\u2010Est,Cr\u00e9teil,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Compagnon","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Pancreato\u2010Biliary Surgery and Liver Transplantation, Henri Mondor Hospital,Assistance Publique\u2010H\u00f4pitaux de Paris\u2010Universit\u00e9 Paris\u2010Est,Cr\u00e9teil,France"},{"name":"Unit 955 INSERM,Cr\u00e9teil,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille","family":"Feray","sequence":"additional","affiliation":[{"name":"Unit 955 INSERM,Cr\u00e9teil,France"},{"name":"Department of Hepatology, Henri Mondor Hospital,Assistance Publique\u2010H\u00f4pitaux de Paris\u2010Universit\u00e9 Paris\u2010Est,Cr\u00e9teil,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Calderaro","sequence":"additional","affiliation":[{"name":"Department of Pathology, Henri Mondor Hospital,Assistance Publique\u2010H\u00f4pitaux de Paris-Universit\u00e9 Paris-Est,Cr\u00e9teil,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Luciani","sequence":"additional","affiliation":[{"name":"Medical Imaging Department, Henri Mondor Hospital,Assistance Publique\u2010H\u00f4pitaux de Paris-Universit\u00e9 Paris-Est,Cr\u00e9teil,France"},{"name":"Unit 955 INSERM,Cr\u00e9teil,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Azoulay","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Pancreato\u2010Biliary Surgery and Liver Transplantation, Henri Mondor Hospital,Assistance Publique\u2010H\u00f4pitaux de Paris\u2010Universit\u00e9 Paris\u2010Est,Cr\u00e9teil,France"},{"name":"Unit 955 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