{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T10:45:56Z","timestamp":1792838756927,"version":"4.5.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T00:00:00Z","timestamp":1521849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T00:00:00Z","timestamp":1521849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>Sustained virological response (SVR) improves survival in post\u2010liver transplant (LT) recurrent hepatitis C. However, the impact of SVR on fibrosis regression is not well defined. In addition, the performance of noninvasive methods to evaluate the presence of fibrosis and portal hypertension (PH) post\u2010SVR has been scarcely evaluated. We aimed to investigate the degree of fibrosis regression (decrease \u22651 METAVIR stage) after\u2010SVR and its associated factors in recurrent hepatitis C, as well as the diagnostic capacity of noninvasive methods in the assessment of liver fibrosis and PH after viral clearance. We evaluated 112 hepatitis C virus\u2013infected LT recipients who achieved SVR between 2001 and 2015. A liver biopsy was performed before treatment and 12 months post\u2010SVR. Hepatic venous pressure gradient (HVPG), liver stiffness measurement (LSM), and Enhanced Liver Fibrosis (ELF) score were also determined at the same time points. Sixty\u2010seven percent of the cohort presented fibrosis regression: 43% in recipients with cirrhosis and 72%\u201085% in the remaining stages (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.002). HVPG, LSM, and ELF significantly decreased post\u2010SVR. Liver function significantly improved, and survival was significantly better in patients achieving fibrosis regression. Baseline HVPG and LSM as well as decompensations before therapy were independent predictors of fibrosis regression. One year post\u2010SVR, LSM had a high diagnostic accuracy to discard the presence of advanced fibrosis (AF) and clinically significant PH (AUROC, 0.902 and 0.888). <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> In conclusion, SVR post\u2010LT induces fibrosis regression in most patients, leading to significant clinical benefits. Pretreatment HVPG and LSM are significant determinants of the likelihood of fibrosis regression. Finally, LSM accurately predicts the presence of AF and PH 1 year after SVR and thus can be used to determine monitoring strategies. (H<jats:sc>epatology<\/jats:sc> 2018;67:1683\u20101694).<\/jats:p>","DOI":"10.1002\/hep.29557","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T15:45:28Z","timestamp":1506613528000},"page":"1683-1694","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":141,"title":["Portal pressure and liver stiffness measurements in the prediction of fibrosis regression after sustained virological response in recurrent hepatitis C"],"prefix":"10.1097","volume":"67","author":[{"given":"Ezequiel","family":"Mauro","sequence":"first","affiliation":[{"name":"Liver Transplant Unit, Liver Unit, IDIBAPS, CIBERehd,Hospital Cl\u00ednic,Barcelona,Spain"},{"name":"Liver Unit,Hospital Italiano,Buenos Aires,Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Crespo","sequence":"additional","affiliation":[{"name":"Liver Transplant Unit, Liver Unit, IDIBAPS, CIBERehd,Hospital Cl\u00ednic,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Montironi","sequence":"additional","affiliation":[{"name":"Pathology Department,Hospital Cl\u00ednic,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u2010Carlota","family":"Londo\u00f1o","sequence":"additional","affiliation":[{"name":"Liver Unit, IDIBAPS, CIBERehd,Hospital Cl\u00ednic,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Hern\u00e1ndez\u2010Gea","sequence":"additional","affiliation":[{"name":"Barcelona Hemodynamics Laboratory, Liver Unit, IDIBAPS, CIBERehd,Hospital Cl\u00ednic,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Liver Transplant Unit, Liver Unit, IDIBAPS, CIBERehd,Hospital Cl\u00ednic,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Sastre","sequence":"additional","affiliation":[{"name":"Liver Transplant Unit, Liver Unit, IDIBAPS, CIBERehd,Hospital Cl\u00ednic,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julissa","family":"Lombardo","sequence":"additional","affiliation":[{"name":"Liver Transplant Unit, Liver Unit, IDIBAPS, CIBERehd,Hospital Cl\u00ednic,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6321-9534","authenticated-orcid":false,"given":"Zoe","family":"Mari\u00f1o","sequence":"additional","affiliation":[{"name":"Liver Unit, IDIBAPS, CIBERehd,Hospital Cl\u00ednic,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Pathology Department,Hospital Cl\u00ednic,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6024-8479","authenticated-orcid":false,"given":"Jordi","family":"Colmenero","sequence":"additional","affiliation":[{"name":"Liver Transplant Unit, Liver Unit, IDIBAPS, CIBERehd,Hospital Cl\u00ednic,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Rimola","sequence":"additional","affiliation":[{"name":"Liver Transplant Unit, Liver Unit, IDIBAPS, CIBERehd,Hospital Cl\u00ednic,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Garcia\u2010Pag\u00e1n","sequence":"additional","affiliation":[{"name":"Barcelona Hemodynamics Laboratory, Liver Unit, IDIBAPS, CIBERehd,Hospital Cl\u00ednic,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e9","family":"Brunet","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology, IDIBAPS, CIBERehd, Hospital Cl\u00ednic,University of Barcelona,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Forns","sequence":"additional","affiliation":[{"name":"Liver Unit, IDIBAPS, CIBERehd,Hospital Cl\u00ednic,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miquel","family":"Navasa","sequence":"additional","affiliation":[{"name":"Liver Transplant Unit, Liver Unit, IDIBAPS, CIBERehd,Hospital Cl\u00ednic,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,3,24]]},"reference":[{"key":"hep29557-bib-0001-20241017","first-page":"152","article-title":"Direct acting antiviral therapy after liver transplantation","volume":"32","year":"2016","journal-title":"Curr Opin Gastroenterol"},{"key":"hep29557-bib-0002-20241017","first-page":"344","article-title":"Treatment of hepatitis C before and after liver 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