{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:02:42Z","timestamp":1792839762232,"version":"4.5.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>\n                    Hepatitis delta virus (HDV) is responsible for the most severe form of acute and chronic viral hepatitis. We previously proposed that the\n                    <jats:italic toggle=\"yes\">Deltavirus<\/jats:italic>\n                    genus is composed of eight major clades. However, few sequences were available to confirm this classification. Moreover, little is known about the structural and functional consequences of HDV variability. One practical consequence is the failure of most quantification assays to properly detect or quantify plasmatic HDV RNA. Between 2001 and 2014, 2,152 HDV strains were prospectively collected and genotyped in our reference laboratory by means of nucleotide sequencing and extensive phylogenetic analyses of a 400\u2010nucleotide region of the genome (\n                    <jats:italic toggle=\"yes\">R0<\/jats:italic>\n                    ) from nucleotides 889 to 1289 encompassing the 3\u2032 end of the delta protein\u2013coding gene. In addition, the full\u2010length genome sequence was generated for 116 strains selected from the different clusters, allowing for in\u2010depth characterization of the HDV genotypes and subgenotypes. This study confirms that the HDV genus is composed of eight genotypes (HDV\u20101 to HDV\u20108) defined by an intergenotype similarity &gt;85% or &gt;80%, according to the partial or full\u2010length genome sequence, respectively. Furthermore, genotypes can be segregated into two to four subgenotypes, characterized by an intersubgenotype similarity &gt;90% (&gt;84% for HDV\u20101) over the whole genome sequence. Systematic analysis of genome and protein sequences revealed highly conserved functional nucleotide and amino acid motifs and positions across all (sub)genotypes, indicating strong conservatory constraints on the structure and function of the genome and the protein.\n                    <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    This study provides insight into the genetic diversity of HDV and a clear view of its geographical localization and allows speculation as to the worldwide spread of the virus, very likely from an initial African origin. (H\n                    <jats:sc>epatology<\/jats:sc>\n                    2017;66:1826\u20131841)\n                  <\/jats:p>","DOI":"10.1002\/hep.29574","type":"journal-article","created":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T13:26:38Z","timestamp":1507555598000},"page":"1826-1841","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":154,"title":["Genetic diversity and worldwide distribution of the deltavirus genus: A study of 2,152 clinical strains"],"prefix":"10.1097","volume":"66","author":[{"given":"Fr\u00e9d\u00e9ric","family":"Le Gal","sequence":"first","affiliation":[{"name":"Laboratoire de Microbiologie Clinique, H\u00f4pitaux Universitaires de Paris Seine Saint\u2010Denis, Site Avicenne,Universit\u00e9 Sorbonne Paris Cit\u00e9,Bobigny,France"},{"name":"Centre national de r\u00e9f\u00e9rence des virus des h\u00e9patites B, C et Delta,Laboratoire de Virologie,Bobigny,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9gol\u00e8ne","family":"Brichler","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie Clinique, H\u00f4pitaux Universitaires de Paris Seine Saint\u2010Denis, Site Avicenne,Universit\u00e9 Sorbonne Paris Cit\u00e9,Bobigny,France"},{"name":"Centre national de r\u00e9f\u00e9rence des virus des h\u00e9patites B, C et Delta,Laboratoire de Virologie,Bobigny,France"},{"name":"Unit\u00e9 INSERM U955,Equipe 18,Cr\u00e9teil,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tudor","family":"Drugan","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics and Biostatistics,Iuliu Hatieganu University of Medicine and Pharmacy,Cluj\u2010Napoca,Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chakib","family":"Alloui","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie Clinique, H\u00f4pitaux Universitaires de Paris Seine Saint\u2010Denis, Site Avicenne,Universit\u00e9 Sorbonne Paris Cit\u00e9,Bobigny,France"},{"name":"Centre national de r\u00e9f\u00e9rence des virus des h\u00e9patites B, C et Delta,Laboratoire de Virologie,Bobigny,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0926-3563","authenticated-orcid":false,"given":"Dominique","family":"Roulot","sequence":"additional","affiliation":[{"name":"Centre national de r\u00e9f\u00e9rence des virus des h\u00e9patites B, C et Delta,Laboratoire de Virologie,Bobigny,France"},{"name":"Unit\u00e9 d'H\u00e9patologie, H\u00f4pitaux Universitaires de Paris Seine Saint\u2010Denis, Site Avicenne,Universit\u00e9 Sorbonne Paris Cit\u00e9,Bobigny,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Michel","family":"Pawlotsky","sequence":"additional","affiliation":[{"name":"Unit\u00e9 INSERM U955,Equipe 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