{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:27:08Z","timestamp":1790332028822,"version":"4.1.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>H19 is an imprinted long noncoding RNA abundantly expressed in embryonic liver and repressed after birth. We show that H19 serves as a lipid sensor by synergizing with the RNA\u2010binding polypyrimidine tract\u2010binding protein 1 (PTBP1) to modulate hepatic metabolic homeostasis. <jats:italic toggle=\"yes\">H19<\/jats:italic> RNA interacts with PTBP1 to facilitate its association with sterol regulatory element\u2010binding protein 1c mRNA and protein, leading to increased stability and nuclear transcriptional activity. H19 and PTBP1 are up\u2010regulated by fatty acids in hepatocytes and in diet\u2010induced fatty liver, which further augments lipid accumulation. Ectopic expression of H19 induces steatosis and pushes the liver into a \u201cpseudo\u2010fed\u201d state in response to fasting by promoting sterol regulatory element\u2010binding protein 1c protein cleavage and nuclear translocation. Deletion of <jats:italic toggle=\"yes\">H19<\/jats:italic> or knockdown of PTBP1 abolishes high\u2010fat and high\u2010sucrose diet\u2013induced steatosis. <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>: Our study unveils an H19\/PTBP1\/sterol regulatory element\u2010binding protein 1 feedforward amplifying signaling pathway to exacerbate the development of fatty liver. (H<jats:sc>epatology<\/jats:sc> 2018;67:1768\u20101783)<\/jats:p>","DOI":"10.1002\/hep.29654","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T15:44:17Z","timestamp":1510760657000},"page":"1768-1783","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":161,"title":["Long noncoding RNA H19 interacts with polypyrimidine tract\u2010binding protein 1 to reprogram hepatic lipid homeostasis"],"prefix":"10.1097","volume":"67","author":[{"given":"Chune","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Physiology and Neurobiology and the Institute for Systems Genomics,University of Connecticut,Storrs,CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neurobiology and the Institute for Systems Genomics,University of Connecticut,Storrs,CT"},{"name":"Veterans 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the Institute for Systems Genomics,University of Connecticut,Storrs,CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neurobiology and the Institute for Systems Genomics,University of Connecticut,Storrs,CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neurobiology and the Institute for Systems Genomics,University of Connecticut,Storrs,CT"},{"name":"Veterans Affairs Connecticut Healthcare System,West Haven,CT"},{"name":"Department of Internal Medicine, Section of Digestive Diseases,Yale University,New Haven,CT"},{"name":"School of Pharmaceutical Sciences,Wenzhou Medical 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