{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T08:29:35Z","timestamp":1785918575246,"version":"3.56.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Primary sclerosing cholangitis (PSC) is a risk factor for cholangiocarcinoma (CCA) and gallbladder carcinoma (GBCa). Surveillance for GBCa is recommended, but the clinical utility of surveillance for other hepatobiliary cancers (HBCa) in PSC, namely CCA and hepatocellular carcinoma (HCC), remains unclear. We aimed to determine whether surveillance is associated with better survival after diagnosis of HBCa in patients with PSC. Medical records of PSC patients seen at the Mayo Clinic Rochester from 1995 to 2015 were reviewed. Patients were included if they had \u22651 year of follow\u2010up and developed HBCa. Patients were categorized according to their surveillance status (abdominal imaging, carbohydrate antigen 19\u20109, and alpha\u2010fetoprotein). The primary endpoints were HBCa recurrence, HBCa\u2010related death, and all\u2010cause mortality. Overall survival was assessed by the Kaplan\u2010Meier survival method; HBCa\u2010related survival was assessed using competing risk regression. Tests of significance were two\u2010tailed, and a <jats:italic toggle=\"yes\">P<\/jats:italic> value &lt;0.05 was considered statistically significant. From 1995 to 2015, a total of 79 of 830 PSC patients were diagnosed with HBCa. Cumulative follow\u2010up was 712 and 283 person\u2010years pre\u2010 and post\u2010HBCa diagnosis, respectively. Seventy\u2010eight percent of patients (54\/79) developed CCA, 21% (17\/79) HCC, 6% (5\/79) GBCa, 3% (2\/79) both CCA and HCC, and 1% (1\/79) both HCC and GBCa. Fifty\u2010one percent (40\/79) were under HBCa surveillance, and 49% (39\/79) were not. Patients in the surveillance group had significantly higher 5\u2010year overall survival (68% versus 20%, respectively; <jats:italic toggle=\"yes\">P &lt;<\/jats:italic> 0.001) and significantly lower 5\u2010year probability of experiencing an HBCa\u2010related adverse event (32% versus 75%, respectively; <jats:italic toggle=\"yes\">P &lt;<\/jats:italic> 0.001) compared with the no\u2010surveillance group. <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> This study demonstrates that HBCa surveillance significantly improves outcomes, including survival, in patients with PSC. (H<jats:sc>epatology<\/jats:sc> 2018;67:2338\u20102351).<\/jats:p>","DOI":"10.1002\/hep.29730","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T21:47:28Z","timestamp":1513460848000},"page":"2338-2351","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":124,"title":["Surveillance for hepatobiliary cancers in patients with primary sclerosing cholangitis"],"prefix":"10.1097","volume":"67","author":[{"given":"Ahmad Hassan","family":"Ali","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Mayo Clinic,Phoenix,AZ"},{"name":"Texas Tech University Health Sciences Center,Amarillo,TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9104-1702","authenticated-orcid":false,"given":"James H.","family":"Tabibian","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine,Olive View\u2010UCLA Medical Center,Sylmar,CA"},{"name":"Division of Gastroenterology and Hepatology,Mayo Clinic,Rochester,MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navine","family":"Nasser\u2010Ghodsi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,Mayo Clinic,Rochester,MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Lennon","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics,Mayo Clinic,Rochester,MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"DeLeon","sequence":"additional","affiliation":[{"name":"Division of Oncology,Mayo Clinic,Scottsdale,AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitesh J.","family":"Borad","sequence":"additional","affiliation":[{"name":"Division of Oncology,Mayo 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