{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:28:41Z","timestamp":1791242921172,"version":"4.1.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>A hallmark of chronic liver injury is fibrosis, with accumulation of extracellular matrix orchestrated by activated hepatic stellate cells (HSCs). Glucocorticoids limit HSC activation <jats:italic toggle=\"yes\">in vitro<\/jats:italic>, and tissue glucocorticoid levels are amplified by 11beta\u2010hydroxysteroid dehydrogenase\u20101 (11\u03b2HSD1). Although 11\u03b2HSD1 inhibitors have been developed for type 2 diabetes mellitus and improve diet\u2010induced fatty liver in various mouse models, effects on the progression and\/or resolution of liver injury and consequent fibrosis have not been characterized. We have used the reversible carbon tetrachloride\u2010induced model of hepatocyte injury and liver fibrosis to show that in two models of genetic 11\u03b2HSD1 deficiency (global, <jats:italic toggle=\"yes\">Hsd11b1<\/jats:italic>\n                           <jats:sup>\u2013\/\u2013<\/jats:sup>, and hepatic myofibroblast\u2010specific, <jats:italic toggle=\"yes\">Hsd11b1<\/jats:italic>\n                           <jats:sup>fl\/fl<\/jats:sup>\/Pdgfrb\u2010cre) 11\u03b2HSD1 pharmacological inhibition <jats:italic toggle=\"yes\">in vivo<\/jats:italic> exacerbates hepatic myofibroblast activation and liver fibrosis. In contrast, liver injury and fibrosis in hepatocyte\u2010specific <jats:italic toggle=\"yes\">Hsd11b1<\/jats:italic>\n                           <jats:sup>fl\/fl<\/jats:sup>\/albumin\u2010cre mice did not differ from that of controls, ruling out 11\u03b2HSD1 deficiency in hepatocytes as the cause of the increased fibrosis. In primary HSC culture, glucocorticoids inhibited expression of the key profibrotic genes <jats:italic toggle=\"yes\">Acta2<\/jats:italic> and <jats:italic toggle=\"yes\">Col1\u03b11<\/jats:italic>, an effect attenuated by the 11\u03b2HSD1 inhibitor [4\u2010(2\u2010chlorophenyl\u20104\u2010fluoro\u20101\u2010piperidinyl][5\u2010(1H\u2010pyrazol\u20104\u2010yl)\u20103\u2010thienyl]\u2010methanone. HSCs from <jats:italic toggle=\"yes\">Hsd11b1<\/jats:italic>\n                           <jats:sup>\u2013\/\u2013<\/jats:sup> and <jats:italic toggle=\"yes\">Hsd11b1<\/jats:italic>\n                           <jats:sup>fl\/fl<\/jats:sup>\/Pdgfrb\u2010cre mice expressed higher levels of <jats:italic toggle=\"yes\">Acta2<\/jats:italic> and <jats:italic toggle=\"yes\">Col1\u03b11<\/jats:italic> and were correspondingly more potently activated. <jats:italic toggle=\"yes\">In vivo<\/jats:italic> [4\u2010(2\u2010chlorophenyl\u20104\u2010fluoro\u20101\u2010piperidinyl][5\u2010(1H\u2010pyrazol\u20104\u2010yl)\u20103\u2010thienyl]\u2010methanone administration prior to chemical injury recapitulated findings in <jats:italic toggle=\"yes\">Hsd11b1<\/jats:italic>\n                           <jats:sup>\u2013\/\u2013<\/jats:sup> mice, including greater fibrosis. <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> 11\u03b2HSD1 deficiency enhances myofibroblast activation and promotes initial fibrosis following chemical liver injury; hence, the effects of 11\u03b2HSD1 inhibitors on liver injury and repair are likely to be context\u2010dependent and deserve careful scrutiny as these compounds are developed for chronic diseases including metabolic syndrome and dementia. (H<jats:sc>epatology<\/jats:sc> 2018;67:2167\u20102181).<\/jats:p>","DOI":"10.1002\/hep.29734","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T15:52:50Z","timestamp":1513612370000},"page":"2167-2181","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":38,"title":["11Beta\u2010hydroxysteroid dehydrogenase\u20101 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis"],"prefix":"10.1097","volume":"67","author":[{"given":"Xiantong","family":"Zou","sequence":"first","affiliation":[{"name":"BHF Centre for Cardiovascular Science,The University of Edinburgh,Edinburgh,UK"},{"name":"MRC Centre for Inflammation Research,The University of Edinburgh,Edinburgh,UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"MRC Centre for Inflammation Research,The University of Edinburgh,Edinburgh,UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4174-2786","authenticated-orcid":false,"given":"Timothy J.","family":"Kendall","sequence":"additional","affiliation":[{"name":"MRC Centre for Inflammation Research,The University of Edinburgh,Edinburgh,UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Pellicoro","sequence":"additional","affiliation":[{"name":"MRC Centre for Inflammation Research,The University of Edinburgh,Edinburgh,UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Dora","sequence":"additional","affiliation":[{"name":"MRC Centre for Inflammation Research,The University of Edinburgh,Edinburgh,UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Aucott","sequence":"additional","affiliation":[{"name":"MRC Centre for Inflammation Research,The University of Edinburgh,Edinburgh,UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kajal","family":"Manwani","sequence":"additional","affiliation":[{"name":"BHF Centre for Cardiovascular Science,The University of Edinburgh,Edinburgh,UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tak Yung","family":"Man","sequence":"additional","affiliation":[{"name":"BHF Centre for Cardiovascular Science,The University of Edinburgh,Edinburgh,UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen E.","family":"Chapman","sequence":"additional","affiliation":[{"name":"BHF Centre for Cardiovascular Science,The University of Edinburgh,Edinburgh,UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil C.","family":"Henderson","sequence":"additional","affiliation":[{"name":"MRC Centre for Inflammation Research,The University of Edinburgh,Edinburgh,UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart J.","family":"Forbes","sequence":"additional","affiliation":[{"name":"MRC Centre for Regenerative Medicine,Queen's Medical Research Institute,Edinburgh,UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott P.","family":"Webster","sequence":"additional","affiliation":[{"name":"BHF Centre for Cardiovascular Science,The University of Edinburgh,Edinburgh,UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Iredale","sequence":"additional","affiliation":[{"name":"MRC Centre for Inflammation Research,The University of Edinburgh,Edinburgh,UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian R.","family":"Walker","sequence":"additional","affiliation":[{"name":"BHF Centre for Cardiovascular Science,The University of Edinburgh,Edinburgh,UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0085-4842","authenticated-orcid":false,"given":"Zoi","family":"Michailidou","sequence":"additional","affiliation":[{"name":"BHF Centre for Cardiovascular Science,The University of Edinburgh,Edinburgh,UK"},{"name":"MRC Centre for Inflammation Research,The University of Edinburgh,Edinburgh,UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"key":"hep29734-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of stellate cell activation","volume":"14","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"hep29734-bib-0002-20241017","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1172\/JCI1018","article-title":"Mechanisms of spontaneous resolution of rat liver fibrosis\u2014hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors","volume":"102","year":"1998","journal-title":"J Clin Invest"},{"key":"hep29734-bib-0003-20241017","first-page":"E3186","article-title":"Differential Ly\u20106C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis","volume":"109","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"hep29734-bib-0004-20241017","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","year":"2008","journal-title":"J Pathol"},{"key":"hep29734-bib-0005-20241017","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nm0111-18","article-title":"Scarred by disease","volume":"17","year":"2011","journal-title":"Nat Med"},{"key":"hep29734-bib-0006-20241017","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/hep.25573","article-title":"Adrenocortical dysfunction in liver disease. A systemic review","volume":"55","year":"2012","journal-title":"Hepatology"},{"key":"hep29734-bib-0007-20241017","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1210\/endo.142.4.8114","article-title":"Minireview: 11beta\u2010hydroxysteroid dehydrogenase type 1\u2014a tissue\u2010specific amplifier of glucocorticoid action","volume":"142","year":"2001","journal-title":"Endocrinology"},{"key":"hep29734-bib-0008-20241017","doi-asserted-by":"crossref","first-page":"41293","DOI":"10.1074\/jbc.M103676200","article-title":"Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta\u2010hydroxysteroid dehydrogenase type 1 null mice","volume":"276","year":"2001","journal-title":"J Biol Chem"},{"key":"hep29734-bib-0009-20241017","doi-asserted-by":"crossref","first-page":"7088","DOI":"10.1073\/pnas.0305524101","article-title":"Metabolic syndrome without obesity: hepatic overexpression of 11beta\u2010hydroxysteroid dehydrogenase type 1 in transgenic mice","volume":"101","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"hep29734-bib-0010-20241017","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/j.1365-2265.2008.03358.x","article-title":"Hepatic 11beta\u2010HSD1 mRNA expression in fatty liver and nonalcoholic steatohepatitis","volume":"70","year":"2009","journal-title":"Clin Endocrinol"},{"key":"hep29734-bib-0011-20241017","doi-asserted-by":"crossref","first-page":"e29531","DOI":"10.1371\/journal.pone.0029531","article-title":"A switch in hepatic cortisol metabolism across the spectrum of non alcoholic fatty liver disease","volume":"7","year":"2012","journal-title":"PLoS One"},{"key":"hep29734-bib-0012-20241017","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1007\/s40265-013-0112-5","article-title":"11\u03b2\u2010HSD1 inhibitors for the treatment of type 2 diabetes and cardiovascular disease","volume":"73","year":"2013","journal-title":"Drugs"},{"key":"hep29734-bib-0013-20241017","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S2213-8587(13)70170-0","article-title":"Inhibition of 11\u03b2\u2010HSD1 with RO5093151 for non\u2010alcoholic fatty liver disease: a multicentre, randomised, double\u2010blind, placebo\u2010controlled trial","volume":"2","year":"2014","journal-title":"Lancet Diabetes Endocrinol"},{"key":"hep29734-bib-0014-20241017","doi-asserted-by":"crossref","first-page":"14924","DOI":"10.1073\/pnas.94.26.14924","article-title":"11Beta\u2010hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid\u2010inducible responses and resist hyperglycemia on obesity or stress","volume":"94","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"hep29734-bib-0015-20241017","doi-asserted-by":"crossref","first-page":"12165","DOI":"10.1073\/pnas.0500641102","article-title":"Preventing local regeneration of glucocorticoids by 11beta\u2010hydroxysteroid dehydrogenase type 1 enhances angiogenesis","volume":"102","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"hep29734-bib-0016-20241017","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.2337\/db10-0830","article-title":"Novel fat depot\u2010specific mechanisms underlie resistance to visceral obesity and inflammation in 11 beta\u2010hydroxysteroid dehydrogenase type 1\u2013deficient mice","volume":"60","year":"2011","journal-title":"Diabetes"},{"key":"hep29734-bib-0017-20241017","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.1074\/jbc.M111.259325","article-title":"Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease\u2010resistant 11 beta\u2010hydroxysteroid dehydrogenase type 1 (HSD1)\u2010deficient mice","volume":"287","year":"2012","journal-title":"J Biol Chem"},{"key":"hep29734-bib-0018-20241017","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1096\/fj.12-219105","article-title":"11\u03b2\u2010hydroxysteroid dehydrogenase type 1 deficiency in bone marrow\u2013derived cells reduces atherosclerosis","volume":"27","year":"2013","journal-title":"FASEB J"},{"key":"hep29734-bib-0019-20241017","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1210\/en.2015-1630","article-title":"Cardiomyocyte and vascular smooth muscle\u2010independent 11\u03b2\u2010hydroxysteroid dehydrogenase 1 amplifies infarct expansion, hypertrophy, and the development of heart failure after myocardial infarction in male mice","volume":"157","year":"2016","journal-title":"Endocrinology"},{"key":"hep29734-bib-0020-20241017","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1038\/nm.3282","article-title":"Targeting of \u03b1v integrin identifies a core molecular pathway that regulates fibrosis in several organs","volume":"19","year":"2013","journal-title":"Nat Med"},{"key":"hep29734-bib-0021-20241017","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1210\/en.2015-1395","article-title":"Cognitive and disease\u2010modifying effects of 11\u03b2\u2010hydroxysteroid dehydrogenase type 1 inhibition in male Tg2576 mice, a model of Alzheimer's disease","volume":"156","year":"2015","journal-title":"Endocrinology"},{"key":"hep29734-bib-0022-20241017","doi-asserted-by":"crossref","first-page":"E402","DOI":"10.1152\/ajpendo.00331.2010","article-title":"Metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency: implications for the pathogenesis of steatohepatitis","volume":"300","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"hep29734-bib-0023-20241017","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1002\/hep.25567","article-title":"Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP\u201012) during experimental liver fibrosis","volume":"55","year":"2012","journal-title":"Hepatology"},{"key":"hep29734-bib-0024-20241017","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","year":"2005","journal-title":"Hepatology"},{"key":"hep29734-bib-0025-20241017","doi-asserted-by":"crossref","first-page":"642","DOI":"10.2337\/db11-1054","article-title":"Optimal elevation of beta\u2010cell 11beta\u2010hydroxysteroid dehydrogenase type 1 is a compensatory mechanism that prevents high\u2010fat diet\u2010induced beta\u2010cell failure","volume":"61","year":"2012","journal-title":"Diabetes"},{"key":"hep29734-bib-0026-20241017","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0960-0760(94)00159-J","article-title":"Cloning, sequencing and tissue\u2010distribution of mouse 11 beta\u2010hydroxysteroid dehydrogenase\u20101 cDNA","volume":"52","year":"1995","journal-title":"J Steroid Biochem Mol Biol"},{"key":"hep29734-bib-0027-20241017","doi-asserted-by":"crossref","first-page":"790","DOI":"10.2337\/db11-0931","article-title":"Salicylate downregulates 11\u03b2\u2010HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization","volume":"61","year":"2012","journal-title":"Diabetes"},{"key":"hep29734-bib-0028-20241017","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/gut.2004.042127","article-title":"Human hepatic stellate cell lines, LX\u20101 and LX\u20102: new tools for analysis of hepatic fibrosis","volume":"54","year":"2005","journal-title":"Gut"},{"key":"hep29734-bib-0029-20241017","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0168-8278(02)00050-8","article-title":"Expression of reelin in hepatic stellate cells and during hepatic tissue repair: a novel marker for the differentiation of HSC from other liver myofibroblasts","volume":"36","year":"2002","journal-title":"J Hepatol"},{"key":"hep29734-bib-0030-20241017","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s12020-016-0928-3","article-title":"Acute liver damage following intravenous glucocorticoid treatment for Graves' ophthalmopathy","volume":"54","year":"2016","journal-title":"Endocrine"},{"key":"hep29734-bib-0031-20241017","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1177\/0192623312447550","article-title":"Metabolic adaptive ALT isoenzyme response in livers of C57\/BL6 mice treated with dexamethasone","volume":"40","year":"2012","journal-title":"Toxicol Pathol"},{"key":"hep29734-bib-0032-20241017","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/dmrr.2655","article-title":"Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level","volume":"31","year":"2015","journal-title":"Diabetes Metab Res Rev"},{"key":"hep29734-bib-0033-20241017","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1210\/en.2012-1019","article-title":"Lack of significant metabolic abnormalities in mice with liver\u2010specific disruption of 11\u03b2\u2010hydroxysteroid dehydrogenase type 1","volume":"153","year":"2012","journal-title":"Endocrinology"},{"key":"hep29734-bib-0034-20241017","first-page":"E2482","article-title":"11\u03b2\u2010HSD1 is the major regulator of the tissue\u2010specific effects of circulating glucocorticoid excess","volume":"111","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"hep29734-bib-0035-20241017","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.metabol.2014.10.012","article-title":"Leptin in nonalcoholic fatty liver disease: a narrative review","volume":"64","year":"2015","journal-title":"Metabolism"},{"key":"hep29734-bib-0036-20241017","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/j.rmed.2009.03.018","article-title":"Budesonide\/formoterol effects on metalloproteolytic balance in TGFbeta\u2010activated human lung fibroblasts","volume":"103","year":"2009","journal-title":"Respir Med"},{"key":"hep29734-bib-0037-20241017","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1440-1681.2011.05581.x","article-title":"A physiological concentration of glucocorticoid inhibits the pro\u2010inflammatory cytokine\u2010induced proliferation of adult rat cardiac fibroblasts: roles of extracellular signal\u2013regulated kinase 1\/2 and nuclear factor\u2010kappaB","volume":"38","year":"2011","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"hep29734-bib-0038-20241017","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.bbrc.2004.10.164","article-title":"Glucocorticoids decrease the bioavailability of TGF\u2010beta which leads to a reduced TGF\u2010beta signaling in hepatic stellate cells","volume":"325","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"hep29734-bib-0039-20241017","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","year":"2013","journal-title":"Nat Commun"},{"key":"hep29734-bib-0040-20241017","first-page":"E3297","article-title":"Origin of myofibroblasts in the fibrotic liver in mice","volume":"111","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"hep29734-bib-0041-20241017","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","year":"2005","journal-title":"J Clin Invest"},{"key":"hep29734-bib-0042-20241017","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1210\/en.2011-1398","article-title":"11\u03b2\u2010Hydroxysteroid dehydrogenase type 1, but not type 2, deficiency worsens acute inflammation and experimental arthritis in mice","volume":"153","year":"2012","journal-title":"Endocrinology"},{"key":"hep29734-bib-0043-20241017","doi-asserted-by":"crossref","first-page":"6325","DOI":"10.4049\/jimmunol.179.9.6325","article-title":"Macrophages from 11 beta\u2010hydroxysteroid dehydrogenase type 1\u2010deficient mice exhibit an increased sensitivity to lipopolysaccharide stimulation due to TGF\u2010beta\u2010mediated up\u2010regulation of SHIP1 expression","volume":"179","year":"2007","journal-title":"J Immunol"},{"key":"hep29734-bib-0044-20241017","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1210\/en.2016-1357","article-title":"Male 11\u03b2\u2010HSD1 knockout mice fed trans\u2010fats and fructose are not protected from metabolic syndrome or nonalcoholic fatty liver disease","volume":"157","year":"2016","journal-title":"Endocrinology"},{"key":"hep29734-bib-0045-20241017","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/cvr\/cvq149","article-title":"Improved heart function follows enhanced inflammatory cell recruitment and angiogenesis in 11 beta HSD1\u2010deficient mice post\u2010MI","volume":"88","year":"2010","journal-title":"Cardiovasc Res"},{"key":"hep29734-bib-0046-20241017","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/hep.20193","article-title":"Angiogenesis in chronic inflammatory liver disease","volume":"39","year":"2004","journal-title":"Hepatology"},{"key":"hep29734-bib-0047-20241017","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1002\/hep.21921","article-title":"Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats","volume":"46","year":"2007","journal-title":"Hepatology"},{"key":"hep29734-bib-0048-20241017","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/hep.21564","article-title":"Sinusoidal remodeling and angiogenesis: a new function for the liver\u2010specific pericyte?","volume":"45","year":"2007","journal-title":"Hepatology"},{"key":"hep29734-bib-0049-20241017","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1053\/j.gastro.2008.07.065","article-title":"Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis","volume":"135","year":"2008","journal-title":"Gastroenterology"},{"key":"hep29734-bib-0050-20241017","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1053\/j.gastro.2014.01.061","article-title":"Vascular endothelial growth factor promotes fibrosis resolution and repair in mice","volume":"146","year":"2014","journal-title":"Gastroenterology"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.29734","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-201806000-00019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:33:47Z","timestamp":1729211627000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-201806000-00019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,22]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.29734","relation":{},"ISSN":["0270-9139","1527-3350"],"issn-type":[{"value":"0270-9139","type":"print"},{"value":"1527-3350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,22]]},"assertion":[{"value":"2016-11-09","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}