{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:24:08Z","timestamp":1790166248485,"version":"4.1.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T00:00:00Z","timestamp":1525910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1002\/hep.29803","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T16:46:59Z","timestamp":1516726019000},"page":"333-348","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":104,"title":["Hepatic stellate cell\u2013derived platelet\u2010derived growth factor receptor\u2010alpha\u2010enriched extracellular vesicles promote liver fibrosis in mice through SHP2"],"prefix":"10.1097","volume":"68","author":[{"given":"Enis","family":"Kostallari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Hirsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Prasnicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas K.","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usman","family":"Yaqoob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicha","family":"Wongjarupong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis R.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay H.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-37-20241017","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3727\/105221615X14181438356210","article-title":"PDGFRalpha in liver pathophysiology: emerging roles in development, regeneration, fibrosis, and cancer","volume":"16","author":"Kikuchi","year":"2015","journal-title":"Gene Expr"},{"key":"R2-37-20241017","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12916-014-0145-y","article-title":"Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis","volume":"12","author":"Mokdad","year":"2014","journal-title":"BMC Med"},{"key":"R3-37-20241017","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/hep.22872","article-title":"Antiangiogenic therapy: not just for cancer anymore?","volume":"49","author":"Shah","year":"2009","journal-title":"Hepatology"},{"key":"R4-37-20241017","doi-asserted-by":"crossref","first-page":"G246","DOI":"10.1152\/ajpgi.00118.2016","article-title":"Angiocrine signaling in the hepatic sinusoids in health and disease","volume":"311","author":"Kostallari","year":"2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R5-37-20241017","first-page":"237","article-title":"The role of innate immunity in alcoholic liver disease","volume":"37","author":"Nagy","year":"2015","journal-title":"Alcohol Res"},{"key":"R6-37-20241017","doi-asserted-by":"crossref","first-page":"G667","DOI":"10.1152\/ajpgi.00050.2016","article-title":"Dysregulation of redox pathways in liver fibrosis","volume":"311","author":"Torok","year":"2016","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R7-37-20241017","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"R8-37-20241017","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0092-8674(90)90801-K","article-title":"Signal transduction by receptors with tyrosine kinase activity","volume":"61","author":"Ullrich","year":"1990","journal-title":"Cell"},{"key":"R9-37-20241017","doi-asserted-by":"crossref","first-page":"5908","DOI":"10.1074\/jbc.273.10.5908","article-title":"A role for Src in signal relay by the platelet\u2010derived growth factor alpha receptor","volume":"273","author":"Gelderloos","year":"1998","journal-title":"J Biol Chem"},{"key":"R10-37-20241017","doi-asserted-by":"crossref","first-page":"6926","DOI":"10.1128\/MCB.16.12.6926","article-title":"Phosphorylation of tyrosine 720 in the platelet\u2010derived growth factor alpha receptor is required for binding of Grb2 and SHP\u20102 but not for activation of Ras or cell proliferation","volume":"16","author":"Bazenet","year":"1996","journal-title":"Mol Cell Biol"},{"key":"R11-37-20241017","doi-asserted-by":"crossref","first-page":"e92925","DOI":"10.1371\/journal.pone.0092925","article-title":"Activation of platelet\u2010derived growth factor receptor alpha contributes to liver fibrosis","volume":"9","author":"Hayes","year":"2014","journal-title":"PLoS One"},{"key":"R12-37-20241017","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1053\/j.gastro.2015.12.037","article-title":"Lipid\u2010induced signaling causes release of inflammatory extracellular vesicles from hepatocytes","volume":"150","author":"Hirsova","year":"2016","journal-title":"Gastroenterology"},{"key":"R13-37-20241017","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1002\/hep.28814","article-title":"Extracellular vesicles in liver pathobiology: small particles with big impact","volume":"64","author":"Hirsova","year":"2016","journal-title":"Hepatology"},{"key":"R14-37-20241017","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jhep.2016.03.004","article-title":"Exosomes in liver pathology","volume":"65","author":"Sato","year":"2016","journal-title":"J Hepatol"},{"key":"R15-37-20241017","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1002\/hep.25873","article-title":"Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug\u2010induced, and inflammatory liver diseases","volume":"56","author":"Bala","year":"2012","journal-title":"Hepatology"},{"key":"R16-37-20241017","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/hep.28252","article-title":"Mixed lineage kinase 3 mediates release of C\u2010X\u2010C motif ligand 10\u2013bearing chemotactic extracellular vesicles from lipotoxic hepatocytes","volume":"63","author":"Ibrahim","year":"2016","journal-title":"Hepatology"},{"key":"R17-37-20241017","doi-asserted-by":"crossref","first-page":"e113651","DOI":"10.1371\/journal.pone.0113651","article-title":"Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver disease","volume":"9","author":"Povero","year":"2014","journal-title":"PLoS One"},{"key":"R18-37-20241017","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.jhep.2015.11.020","article-title":"Alcohol stimulates macrophage activation through caspase\u2010dependent hepatocyte derived release of CD40L containing extracellular vesicles","volume":"64","author":"Verma","year":"2016","journal-title":"J Hepatol"},{"key":"R19-37-20241017","doi-asserted-by":"crossref","first-page":"30684","DOI":"10.1074\/jbc.M115.671735","article-title":"Exosome adherence and internalization by hepatic stellate cells triggers sphingosine 1\u2010phosphate\u2010dependent migration","volume":"290","author":"Wang","year":"2015","journal-title":"J Biol Chem"},{"key":"R21-37-20241017","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/hep.28921","article-title":"The unfolded protein response mediates fibrogenesis and collagen I secretion through regulating TANGO1 in mice","volume":"65","author":"Maiers","year":"2017","journal-title":"Hepatology"},{"key":"R22-37-20241017","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1002\/sctm.16-0226","article-title":"Extracellular vesicles from bone marrow\u2013derived mesenchymal stem cells improve survival from lethal hepatic failure in mice","volume":"6","author":"Haga","year":"2017","journal-title":"Stem Cells Transl Med"},{"key":"R23-37-20241017","doi-asserted-by":"crossref","first-page":"E968","DOI":"10.1073\/pnas.1521230113","article-title":"Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes","volume":"113","author":"Kowal","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"R24-37-20241017","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/ncb983","article-title":"Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation","volume":"5","author":"Haglund","year":"2003","journal-title":"Nat Cell Biol"},{"key":"R25-37-20241017","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.cytogfr.2004.03.003","article-title":"PDGF signaling in cells and mice","volume":"15","author":"Tallquist","year":"2004","journal-title":"Cytokine Growth Factor Rev"},{"key":"R26-37-20241017","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1034\/j.1600-0854.2001.020103.x","article-title":"Regulation of receptor tyrosine kinase signaling by endocytic trafficking","volume":"2","author":"Wiley","year":"2001","journal-title":"Traffic"},{"key":"R27-37-20241017","doi-asserted-by":"crossref","first-page":"29447","DOI":"10.1074\/jbc.270.49.29447","article-title":"Degradation process of ligand\u2010stimulated platelet\u2010derived growth factor beta\u2010receptor involves ubiquitin\u2010proteasome proteolytic pathway","volume":"270","author":"Mori","year":"1995","journal-title":"J Biol Chem"},{"key":"R28-37-20241017","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.canlet.2005.01.039","article-title":"An aberrant autocrine activation of the platelet\u2010derived growth factor alpha\u2010receptor in follicular and papillary thyroid carcinoma cell lines","volume":"231","author":"Chen","year":"2006","journal-title":"Cancer Lett"},{"key":"R29-37-20241017","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1074\/mcp.M112.017905","article-title":"Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues","volume":"11","author":"Wagner","year":"2012","journal-title":"Mol Cell Proteomics"},{"key":"R30-37-20241017","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3389\/fimmu.2014.00403","article-title":"Exosomes and autophagy: coordinated mechanisms for the maintenance of cellular fitness","volume":"5","author":"Baixauli","year":"2014","journal-title":"Front Immunol"},{"key":"R31-37-20241017","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.cellbio.23.090506.123319","article-title":"Biogenesis and function of multivesicular bodies","volume":"23","author":"Piper","year":"2007","journal-title":"Annu Rev Cell Dev Biol"},{"key":"R32-37-20241017","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.4049\/jimmunol.1403186","article-title":"Ubiquitination as a mechanism to transport soluble mycobacterial and eukaryotic proteins to exosomes","volume":"195","author":"Smith","year":"2015","journal-title":"J Immunol"},{"key":"R33-37-20241017","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1038\/onc.2011.436","article-title":"Dynamin 2 mediates PDGFRalpha\u2013SHP\u20102\u2010promoted glioblastoma growth and invasion","volume":"31","author":"Feng","year":"2012","journal-title":"Oncogene"},{"key":"R34-37-20241017","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nature18621","article-title":"Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases","volume":"535","author":"Chen","year":"2016","journal-title":"Nature"},{"key":"R35-37-20241017","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ejmg.2015.08.005","article-title":"SHP2 sails from physiology to pathology","volume":"58","author":"Tajan","year":"2015","journal-title":"Eur J Med Genet"},{"key":"R36-37-20241017","doi-asserted-by":"crossref","first-page":"29254","DOI":"10.3402\/jev.v5.29254","article-title":"Identification and characterization of EGF receptor in individual exosomes by fluorescence\u2010activated vesicle sorting","volume":"5","author":"Higginbotham","year":"2016","journal-title":"J Extracell Vesicles"},{"key":"R37-37-20241017","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrd3978","article-title":"Extracellular vesicles: biology and emerging therapeutic opportunities","volume":"12","author":"El Andaloussi","year":"2013","journal-title":"Nat Rev Drug Discov"},{"key":"R38-37-20241017","doi-asserted-by":"crossref","first-page":"e17180","DOI":"10.7554\/eLife.17180","article-title":"Tetherin is an exosomal tether","volume":"5","author":"Edgar","year":"2016","journal-title":"Elife"},{"key":"R39-37-20241017","doi-asserted-by":"crossref","first-page":"13588","DOI":"10.1038\/ncomms13588","article-title":"ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins","volume":"7","author":"Villarroya\u2010Beltri","year":"2016","journal-title":"Nat Commun"},{"key":"R40-37-20241017","doi-asserted-by":"crossref","first-page":"7040","DOI":"10.1074\/jbc.M115.636498","article-title":"Dysfunction of platelet\u2010derived growth factor receptor alpha (PDGFRalpha) represses the production of oligodendrocytes from arylsulfatase A\u2013deficient multipotential neural precursor cells","volume":"290","author":"Pituch","year":"2015","journal-title":"J Biol Chem"},{"key":"R41-37-20241017","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1083\/jcb.201504136","article-title":"RAL\u20101 controls multivesicular body biogenesis and exosome secretion","volume":"211","author":"Hyenne","year":"2015","journal-title":"J Cell Biol"},{"key":"R42-37-20241017","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.celrep.2016.03.085","article-title":"KRAS\u2010MEK signaling controls Ago2 sorting into exosomes","volume":"15","author":"McKenzie","year":"2016","journal-title":"Cell Rep"},{"key":"R43-37-20241017","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1242\/jcs.03315","article-title":"Sorting of Fas ligand to secretory lysosomes is regulated by mono\u2010ubiquitylation and phosphorylation","volume":"120","author":"Zuccato","year":"2007","journal-title":"J Cell Sci"},{"key":"R44-37-20241017","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nm.2645","article-title":"Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor\u2010initiating cells via activation of key transcription factors and a positive feedback signaling loop","volume":"18","author":"Aceto","year":"2012","journal-title":"Nat Med"},{"key":"R45-37-20241017","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.jhep.2015.03.036","article-title":"PTPN11\/Shp2 overexpression enhances liver cancer progression and predicts poor prognosis of patients","volume":"63","author":"Han","year":"2015","journal-title":"J Hepatol"},{"key":"R46-37-20241017","doi-asserted-by":"crossref","first-page":"e12223","DOI":"10.7554\/eLife.12223","article-title":"EGF\u2010dependent re\u2010routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling","volume":"4","author":"Baumdick","year":"2015","journal-title":"Elife"},{"key":"R47-37-20241017","doi-asserted-by":"crossref","first-page":"8453","DOI":"10.1074\/jbc.M116.716316","article-title":"Cancer cell\u2013derived exosomes induce mitogen\u2010activated protein kinase\u2013dependent monocyte survival by transport of functional receptor tyrosine kinases","volume":"291","author":"Song","year":"2016","journal-title":"J Biol Chem"},{"key":"R48-37-20241017","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1002\/1873-3468.12448","article-title":"Integrins and heparan sulfate proteoglycans on hepatic stellate cells (HSC) are novel receptors for HSC\u2010derived exosomes","volume":"590","author":"Chen","year":"2016","journal-title":"FEBS Lett"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.29803","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-201807000-00037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T23:37:26Z","timestamp":1729208246000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-201807000-00037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.29803","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]}}}