{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T10:24:35Z","timestamp":1786357475666,"version":"build-2736575974"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>MicroRNA 155 (miR\u2010155) is involved in immune and inflammatory diseases and is associated with liver fibrosis and steatohepatitis. However, the mechanisms involved in miR\u2010155 regulation of liver injury are largely unknown. The role of miR\u2010155 in acute liver injury was assessed in wild\u2010type (WT), miR\u2010155<jats:sup>\u2212\/\u2212<\/jats:sup>, and miR\u2010155<jats:sup>\u2212\/\u2212<\/jats:sup> mice transplanted with WT bone marrow. Additionally, miR\u2010155 expression was evaluated in liver tissue and peripheral blood mononuclear cells of patients with autoimmune hepatitis. Concanavalin A, but not acetaminophen, treatment increased the expression of miR\u2010155 in liver tissue of WT mice. Concanavalin A induced increases in cell death, liver aminotransferases, and expression of proinflammatory cytokines (chemokine [C\u2010X\u2010C motif] ligands 1, 5, 9, 10, and 11; chemokine [C\u2010C motif] ligands 2 and 20; and intercellular cell adhesion molecule 1) in miR\u2010155<jats:sup>\u2212\/\u2212<\/jats:sup> compared to WT mice. Importantly, these animals showed a significant decrease in cluster of differentiation 4\u2013positive\/chemokine (C\u2010X\u2010C motif) receptor 3\u2013positive and forkhead box p3\u2013positive cell recruitment but no changes in other inflammatory cell populations. Mechanistically, miR\u2010155\u2010deficient regulatory T cells showed increased SH2 domain\u2013containing inositol 5\u2010phosphatase 1 expression, a known target of miR\u2010155. Inhibition of SH2 domain\u2013containing inositol 5\u2010phosphatase 1 in miR\u2010155<jats:sup>\u2212\/\u2212<\/jats:sup> mice restored forkhead box p3 recruitment and reduced liver cytokine expression. Transplantation of bone marrow from WT animals into miR\u2010155<jats:sup>\u2212\/\u2212<\/jats:sup> mice partially reversed the effect of concanavalin A on miR\u2010155<jats:sup>\u2212\/\u2212<\/jats:sup> mice as assessed by proinflammatory cytokines and cell death protein expression. Patients with autoimmune hepatitis showed a marked increase in miR\u2010155 expression in the liver but reduced expression of miR\u2010155 in peripheral blood mononuclear cells. <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> miR\u2010155 expression is altered in both liver tissue and circulating inflammatory cells during liver injury, thus regulating inflammatory cell recruitment and liver damage; these results suggest that maintaining miR\u2010155 expression in inflammatory cells might be a potential strategy to modulate liver injury. (H<jats:sc>epatology<\/jats:sc> 2018).<\/jats:p>","DOI":"10.1002\/hep.29833","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T21:16:33Z","timestamp":1518124593000},"page":"691-706","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":65,"title":["Expression of microRNA\u2010155 in inflammatory cells modulates liver injury"],"prefix":"10.1097","volume":"68","author":[{"given":"Delia","family":"Blaya","sequence":"first","affiliation":[{"name":"Laboratory of Liver Cell Plasticity and Tissue Repair,Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS)"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Aguilar\u2010Bravo","sequence":"additional","affiliation":[{"name":"Laboratory of Liver Cell Plasticity and Tissue 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