{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:35:58Z","timestamp":1758807358727,"version":"3.27.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T00:00:00Z","timestamp":1538697600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>Progenitor\u2010derived regeneration gives rise to the aberrant expression of biliary markers such as cytokeratin 7 (K7) and epithelial cell adhesion molecule (EpCAM) in hepatocytes. We aimed to describe the expression of these molecules in patients with compensated hepatitis C virus (HCV)\u2013related cirrhosis and to investigate its potential influence on cirrhosis complications. Among patients with Child\u2010Pugh A uncomplicated HCV\u2010related cirrhosis enrolled in the prospective ANRS CO12 CirVir cohort, we selected individuals with a liver biopsy collected within 2 years before inclusion in the study. K7 and EpCAM immunostaining identified intermediate hepatobiliary cells. The influence of biliary marker expres\u2010sion in hepatocytes on decompensation events and the occurrence of hepatocellular carcinoma (HCC) was studied using a multivariate Cox proportional hazards regression model. Among the 337 patients eligible for the study (men, 67%; median age, 52 years), 198 (58.8%) had biopsies with K7\u2010positive hepatocytes including extensive staining in 40 (11.9%) and 203 had EpCAM\u2010positive hepatocytes (60.6%). During follow\u2010up (median, 54.2 months), 47 patients (14%) experienced a decompensation event, and HCC was diagnosed in 37 patients (11%). Extensive K7 staining was independently associated with the occurrence of a decompensation event (hazard ratio [HR], 3.00; 95% confidence interval [CI], 1.30\u20106.89; P = 0.010). EpCAM expression was independently associated with HCC occurrence (HR, 2.37; 95% CI, 1.07\u20105.23; P =0.033) along with age and a low prothrombin ratio. Conclusion: Progenitor\u2010derived regeneration depicted by K7 and EpCAM immunostaining of hepatocytes in liver biopsies of patients with compensated HCV\u2010related cirrhosis marks a cirrhosis stage more prone to develop complications. (HEPATOLOGY 2018; 68:1534\u20101548).<\/jats:p>","DOI":"10.1002\/hep.29927","type":"journal-article","created":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T03:26:23Z","timestamp":1523417183000},"page":"1534-1548","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Influence of Progenitor\u2010Derived Regeneration Markers on Hepatitis C Virus\u2013Related Cirrhosis Outcome (ANRS CO12 CirVir Cohort)"],"prefix":"10.1097","volume":"68","author":[{"given":"Dominique","family":"Wendum","sequence":"first","affiliation":[{"name":"APHP, H\u00f4pital St. Antoine, Anatomie Pathologiques"},{"name":"Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06, INSERM UMRS_938 Centre de Recherche St. Antoine (CRSA),Paris,France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Layese","sequence":"additional","affiliation":[{"name":"APHP, H\u00f4pital Henri Mondor, Unit\u00e9 de recherche 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Bordeaux,UMR1053 Bordeaux Research in Translational Oncology BaRITOn,Bordeaux,France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Sturm","sequence":"additional","affiliation":[{"name":"CHU Grenoble,D\u00e9partement de Pathologie,Grenoble,France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Sattonnet","sequence":"additional","affiliation":[{"name":"Selarl Diag,Nice,France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Nahon","sequence":"additional","affiliation":[{"name":"APHP, H\u00f4pital Jean Verdier, Service d\u2019h\u00e9patologie,Bondy,France"},{"name":"Universit\u00e9 Paris 13, Sorbonne Paris\u2010Cit\u00e9,Bobigny,France"},{"name":"INSERM UMR 1162, G\u00e9nomique fonctionnelle des tumeurs solides, Universit\u00e9 Paris Descartes, Universit\u00e9 Paris 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