{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:04:32Z","timestamp":1790741072236,"version":"4.1.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>Patient reporting suggests that the physical and psychological effects of autoimmune hepatitis (AIH) can be substantial. However, health\u2010related quality of life (HRQOL) in patients with AIH remains incompletely characterized, and health utility remains to be explored. Treatment for AIH often includes the use of corticosteroids, which are agents that can be associated with significant adverse effects. Here we explore the impact of AIH and its treatments on patient\u2010reported HRQOL and health utility in a large cohort of prevalent cases from the United Kingdom Autoimmune Hepatitis (UK\u2010AIH) national study. Data were collected from 990 adult participants with a clinical diagnosis of AIH using validated HRQOL tools including the European Quality\u2010of\u2010Life 5\u2010Dimension 5\u2010Level (EQ\u20105D\u20105L) and clinical data forms. The EQ\u20105D\u20105L dimension scores were compared with UK population norms and with a disease control cohort with primary biliary cholangitis (PBC). Within the AIH cohort, regression analysis was used to explore associations between HRQOL and demographic and clinical variables with a particular focus on the impact of AIH therapies including corticosteroid use. HRQOL, measured by the EQ\u20105D\u20105L utility index, is shown to be significantly impaired in our cohort of AIH patients compared with population norms. Within the AIH cohort, corticosteroid use was found to be significantly associated with impaired HRQOL, even when controlling for biochemical disease activity status. <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> Our data show evidence of HRQOL impairment in a large cohort of AIH patients compared with the general population. Furthermore, corticosteroid use is strongly associated with decreased HRQOL, independent of remission status. This highlights the need for better corticosteroid\u2010free therapy approaches and it emphasizes the need for future novel therapeutic trials in AIH. (H<jats:sc>epatology<\/jats:sc> 2018; 00:000\u2010000).<\/jats:p>","DOI":"10.1002\/hep.30031","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T08:45:10Z","timestamp":1523954710000},"page":"1487-1497","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":71,"title":["The Impact of Autoimmune Hepatitis and Its Treatment on Health Utility"],"prefix":"10.1097","volume":"68","author":[{"given":"Lin Lee","family":"Wong","sequence":"first","affiliation":[{"name":"Institute of Cellular Medicine,Newcastle University,Newcastle upon Tyne,United Kingdom"},{"name":"Liver Unit, Freeman Hospital,The Newcastle upon Tyne NHS Foundation Trust,Newcastle upon Tyne,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly F","family":"Fisher","sequence":"additional","affiliation":[{"name":"Institute of Health and Society,Newcastle University,Newcastle upon Tyne,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah D","family":"Stocken","sequence":"additional","affiliation":[{"name":"Leeds Institute of Clinical Trials Research,University of Leeds,Leeds,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Rice","sequence":"additional","affiliation":[{"name":"Institute of Health and Society,Newcastle University,Newcastle upon Tyne,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amardeep","family":"Khanna","sequence":"additional","affiliation":[{"name":"Institute of Cellular Medicine,Newcastle University,Newcastle upon Tyne,United Kingdom"},{"name":"Liver Unit, Freeman Hospital,The Newcastle upon Tyne NHS Foundation Trust,Newcastle upon Tyne,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Heneghan","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies,King\u2019s College Hospital,London,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye Htun","family":"Oo","sequence":"additional","affiliation":[{"name":"Centre for Liver Research and NIHR BRC,University of Birmingham and Liver Unit, University Hospital Birmingham NHS Foundation Trust,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Mells","sequence":"additional","affiliation":[{"name":"Academic Department of Medical Genetics,University of Cambridge and Addenbrooke\u2019s Hospital,Cambridge Biomedical Campus,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Kendrick","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline (GSK),Research and Development,Hertfordshire,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica Katharine","family":"Dyson","sequence":"additional","affiliation":[{"name":"Institute of Cellular Medicine,Newcastle University,Newcastle upon Tyne,United Kingdom"},{"name":"Liver Unit, Freeman Hospital,The Newcastle upon Tyne NHS Foundation Trust,Newcastle upon Tyne,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E. 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