{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:59:26Z","timestamp":1790247566529,"version":"4.1.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>The liver has an extraordinary capacity to regenerate through activation of key molecular pathways. However, central regulators controlling liver regeneration remain insufficiently studied. Here, we show that B cell\u2013deficient animals failed to induce sufficient liver regeneration after partial hepatectomy (PHx). Consistently, adoptive transfer of B cells could rescue defective liver regeneration. B cell\u2013mediated lymphotoxin beta production promoted recovery from PHx. Absence of B cells coincided with loss of splenic cluster of differentiation 169\u2013positive (CD169<jats:sup>+<\/jats:sup>) macrophages. Moreover, depletion of CD169<jats:sup>+<\/jats:sup> cells resulted in defective liver regeneration and decreased survival, which was associated with reduced hepatocyte proliferation. Mechanistically, CD169<jats:sup>+<\/jats:sup> cells contributed to liver regeneration by inducing hepatic interleukin\u20106 (IL\u20106) production and signal transducer and activator of transcription 3 activation. Accordingly, treatment of CD169<jats:sup>+<\/jats:sup> cell\u2013depleted animals with IL\u20106\/IL\u20106 receptor rescued liver regeneration and severe pathology following PHx. <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> We identified CD169<jats:sup>+<\/jats:sup> cells to be a central trigger for liver regeneration, by inducing key signaling pathways important for liver regeneration.<\/jats:p>","DOI":"10.1002\/hep.30088","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T23:40:16Z","timestamp":1525909216000},"page":"2348-2361","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":30,"title":["B Cell\u2010Mediated Maintenance of Cluster of Differentiation 169\u2013Positive Cells Is Critical for Liver Regeneration"],"prefix":"10.1097","volume":"68","author":[{"given":"Kristina","family":"Behnke","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine II, Medical 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