{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T21:08:55Z","timestamp":1784581735177,"version":"3.55.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>Acute kidney injury in decompensated cirrhosis has limited therapeutic options, and novel mechanistic targets are urgently needed. Angiopoietin\u20102 is a context\u2010specific antagonist of Tie2, a receptor that signals vascular quiescence. Considering the prominence of vascular destabilization in decompensated cirrhosis, we evaluated Angiopoietin\u20102 to predict clinical outcomes. Serum Angiopoietin\u20102 was measured serially in a prospective cohort of hospitalized patients with decompensated cirrhosis and acute kidney injury. Clinical characteristics and outcomes were examined over a 90\u2010day period and analyzed according to Angiopoietin\u20102 levels. Primary outcome was 90\u2010day mortality. Our study included 191 inpatients (median Angiopoietin\u20102 level 18.2 [interquartile range 11.8, 26.5]\u00a0ng\/mL). Median Model for End\u2010Stage Liver Disease (MELD) score was 23 [17, 30] and 90\u2010day mortality was 41%. Increased Angiopoietin\u20102 levels were associated with increased mortality (died 21.9 [13.9, 30.3]\u00a0ng\/mL vs. alive 15.2 [9.8, 23.0]\u00a0ng\/mL; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001), higher Acute Kidney Injury Network stage (stage I 13.4 [9.8, 20.1]\u00a0ng\/mL vs. stage II 20.0 [14.1, 26.2]\u00a0ng\/mL vs. stage III 21.9 [13.0, 29.5]\u00a0ng\/mL; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.002), and need for renal replacement therapy (16.5 [11.3, 23.6]\u00a0ng\/mL vs. 25.1 [13.3, 30.3]\u00a0ng\/mL; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.005). The association between Angiopoietin\u20102 and mortality was significant in unadjusted and adjusted Cox regression models (<jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0\u2264\u00a00.001 for all models), and improved discrimination for mortality when added to MELD score (integrated discrimination increment 0.067; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.001). <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>: Angiopoietin\u20102 was associated with mortality and other clinically relevant outcomes in a cohort of patients with decompensated cirrhosis with acute kidney injury. Further experimental study of Angiopoietin\/Tie2 signaling is warranted to explore its potential mechanistic and therapeutic role in this population.<\/jats:p>","DOI":"10.1002\/hep.30230","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T01:39:51Z","timestamp":1535074791000},"page":"729-741","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":38,"title":["Serum Angiopoietin\u20102 Predicts Mortality and Kidney Outcomes in Decompensated Cirrhosis"],"prefix":"10.1097","volume":"69","author":[{"given":"Andrew S.","family":"Allegretti","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine,Massachusetts General Hospital,Boston,MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Vela Parada","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine,Massachusetts General Hospital,Boston,MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo A.","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Department of Medicine,St. Elizabeth's Hospital,Boston,MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Long","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine,Massachusetts General Hospital,Boston,MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Krinsky","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine,Massachusetts General Hospital,Boston,MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine,Massachusetts General Hospital,Boston,MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan C.","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Department of Surgery,Massachusetts General Hospital,Boston,MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mozhdeh","family":"Sojoodi","sequence":"additional","affiliation":[{"name":"Department of Surgery,Massachusetts General Hospital,Boston,MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine,Beth Israel Deaconess Medical Center,Boston,MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Ananth","family":"Karumanchi","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine,Beth Israel Deaconess Medical Center,Boston,MA"},{"name":"Departments of Medicine and Biomedical Sciences,Cedars\u2010Sinai Medical Center,Los Angeles,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahir","family":"Kalim","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine,Massachusetts General Hospital,Boston,MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar U.","family":"Nigwekar","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine,Massachusetts General Hospital,Boston,MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi I.","family":"Thadhani","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine,Massachusetts General Hospital,Boston,MA"},{"name":"Departments of Medicine and Biomedical Sciences,Cedars\u2010Sinai Medical Center,Los Angeles,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir M.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine,Beth Israel Deaconess Medical Center,Boston,MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond T.","family":"Chung","sequence":"additional","affiliation":[{"name":"Liver Center and Gastrointestinal Division, Department of Medicine,Massachusetts General Hospital,Boston,MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,1,4]]},"reference":[{"key":"hep30230-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1136\/gutjnl-2014-308874","article-title":"Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of 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