{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:46:44Z","timestamp":1791481604581,"version":"4.3.4"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>\n                    The diagnosis of biliary atresia (BA) remains a clinical challenge because affected infants have signs, symptoms, and serum liver biochemistry that are also seen in those with other causes of neonatal cholestasis (non\u2010BA). However, an early diagnosis and prompt surgical treatment are required to improve clinical outcome. Recently, the relative abundance of serum matrix metalloproteinase\u20107 (MMP\u20107) was suggested to have discriminatory features for infants with BA. To test the hypothesis that elevated serum concentration of MMP\u20107 is highly diagnostic for BA, we determined the normal serum concentration of MMP\u20107 in healthy control infants, and then in 135 consecutive infants being evaluated for cholestasis. The median concentration for MMP\u20107 was 2.86 ng\/mL (interquartile range, IQR: 1.32\u20105.32) in normal controls, 11.47 ng\/mL (IQR: 8.54\u201024.55) for non\u2010BA, and 121.1 ng\/mL (IQR: 85.42\u2010224.4) for BA (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.0001). The area under the curve of MMP\u20107 for the diagnosis of BA was 0.9900 with a cutoff value of 52.85 ng\/mL; the diagnostic sensitivity and specificity were 98.67% and 95.00%, respectively, with a negative predictive value of 98.28%.\n                    <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    Serum MMP\u20107 assay has high sensitivity and specificity to differentiate BA from other neonatal cholestasis, and may be a reliable biomarker for BA.\n                  <\/jats:p>","DOI":"10.1002\/hep.30234","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T01:04:06Z","timestamp":1535591046000},"page":"2069-2077","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":140,"title":["Diagnostic Accuracy of Serum Matrix Metalloproteinase\u20107 for Biliary Atresia"],"prefix":"10.1097","volume":"68","author":[{"given":"Li","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China"},{"name":"Division of Gastroenterology, Hepatology and Nutrition,Cincinnati Children\u2019s Hospital Medical Center,Cincinnati,OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010pei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reena","family":"Mourya","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition,Cincinnati Children\u2019s Hospital Medical Center,Cincinnati,OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010yan","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery,Wuhan Children\u2019s Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010qing","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010li","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine,Wuhan Children\u2019s Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,Hubei Women and Children\u2019s Hospital,Wuhan,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu\u2010fei","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery,Wuhan Children\u2019s Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8187-6295","authenticated-orcid":false,"given":"Lin","family":"Fei","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Epidemiology,Cincinnati Children\u2019s Hospital Medical Center,Cincinnati,OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010pan","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9667-7742","authenticated-orcid":false,"given":"Jorge A.","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition,Cincinnati Children\u2019s Hospital Medical Center,Cincinnati,OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao\u2010tao","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,11,15]]},"reference":[{"key":"hep30234-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"e0176275","DOI":"10.1371\/journal.pone.0176275","article-title":"Initial assessment of the infant with neonatal cholestasis\u2010Is this biliary atresia?","volume":"12","year":"2017","journal-title":"PLoS One"},{"key":"hep30234-bib-0002-20241017","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/MPG.0000000000000755","article-title":"Biliary atresia: clinical lessons learned","volume":"61","year":"2015","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"hep30234-bib-0003-20241017","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/lt.24640","article-title":"Biliary atresia: indications and timing of liver transplantation and optimization of pretransplant care","volume":"23","year":"2017","journal-title":"Liver 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