{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T22:34:07Z","timestamp":1776119647070,"version":"3.50.1"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T00:00:00Z","timestamp":1551830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T00:00:00Z","timestamp":1551830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>The presence of gallstone disease (GSD) was reported to be positively associated with diabetes risk. Whether the association is causal remains unclear. We aim to examine the potential causal association between GSD and type 2 diabetes risk using a Mendelian randomization analysis. Observational study was conducted among 16,299 participants who were free of cancer, heart disease, stroke, and diabetes at baseline in the Dongfeng\u2010Tongji cohort study. GSD was diagnosed by experienced physicians by abdominal B\u2010type ultrasound inspection and type 2 diabetes was defined according to the criteria of the American Diabetes Association. Cox proportional hazard regression model was used to examine the association of GSD with type 2 diabetes risk. A genetic risk score (GRS) for GSD was constructed with eight single nucleotide polymorphisms that were derived from the previous genome\u2010wide association studies. The causal associations of the score for GSD with type 2 diabetes were tested among 7,000 participants in Mendelian randomization analysis. We documented 1,110 incident type 2 diabetes cases during 73,895 person\u2010years of follow\u2010up from 2008 to 2013 (median 4.6 years). Compared with participants without GSD, the multivariate\u2010adjusted hazard ratio of type 2 diabetes risk in those with GSD was 1.22 (95% confidence interval [CI], 1.03\u20101.45, <jats:italic toggle=\"yes\">P\u00a0<\/jats:italic>=\u00a00.02). Each 1 SD (0.23) increment in the weighted GRS was associated with a 17% increment of type 2 diabetes risk (odds ratio\u00a0=\u00a01.17, 95% CI, 0.90\u20101.52) without statistical significance (<jats:italic toggle=\"yes\">P\u00a0<\/jats:italic>=\u00a00.25). <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic> The present study supported a positive but not a causal association of GSD with type 2 diabetes risk. More studies are needed to verify our findings.<\/jats:p>","DOI":"10.1002\/hep.30403","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T07:39:46Z","timestamp":1543995586000},"page":"610-620","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":44,"title":["Gallstone Disease and Type 2 Diabetes Risk: A Mendelian Randomization Study"],"prefix":"10.1097","volume":"70","author":[{"given":"Fei","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaru","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College,Huazhong University of Science and Technology,Wuhan,P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Handong","family":"Yang","sequence":"additional","affiliation":[{"name":"Dongfeng Central Hospital,Dongfeng Motor Corporation and Hubei University of Medicine,Shiyan,Hubei,P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tangchun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meian","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2019,3,6]]},"reference":[{"key":"hep30403-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1001\/jama.2016.19720","article-title":"Association between diabetes and cause\u2010specific mortality in rural and urban areas of China","volume":"317","year":"2017","journal-title":"JAMA"},{"key":"hep30403-bib-0002-20241017","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 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