{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:59:01Z","timestamp":1790477941884,"version":"4.1.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T00:00:00Z","timestamp":1558396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T00:00:00Z","timestamp":1558396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>\n                    In patients with idiopathic noncirrhotic portal hypertension (INCPH), data on morbidity and mortality of abdominal surgery are scarce. We retrospectively analyzed the charts of patients with INCPH undergoing abdominal surgery within the Vascular Liver Disease Interest Group network. Forty\u2010four patients with biopsy\u2010proven INCPH were included. Twenty\u2010five (57%) patients had one or more extrahepatic conditions related to INCPH, and 16 (36%) had a history of ascites. Forty\u2010five procedures were performed, including 30 that were minor and 15 major. Nine (20%) patients had one or more Dindo\u2010Clavien grade\u00a0\u2265\u00a03 complication within 1 month after surgery. Sixteen (33%) patients had one or more portal hypertension\u2013related complication within 3 months after surgery. Extrahepatic conditions related to INCPH (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u00a0=\u00a00.03) and history of ascites (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u00a0=\u00a00.02) were associated with portal hypertension\u2013related complications within 3 months after surgery. Splenectomy was associated with development of portal vein thrombosis after surgery (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u00a0=\u00a00.01). Four (9%) patients died within 6 months after surgery. Six\u2010month cumulative risk of death was higher in patients with serum creatinine\u00a0\u2265\u00a0100 \u03bcmol\/L at surgery (33% versus 0%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). An unfavorable outcome (i.e., either liver or surgical complication or death) occurred in 22 (50%) patients and was associated with the presence of extrahepatic conditions related to INCPH, history of ascites, and serum creatinine\u00a0\u2265\u00a0100 \u03bcmol\/L: 5% of the patients with none of these features had an unfavorable outcome versus 32% and 64% when one or two or more features were present, respectively. Portal decompression procedures prior to surgery (n\u00a0=\u00a010) were not associated with postoperative outcome.\n                    <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>\n                    : Patients with INCPH are at high risk of major surgical and portal hypertension\u2013related complications when they harbor extrahepatic conditions related to INCPH, history of ascites, or increased serum creatinine.\n                  <\/jats:p>","DOI":"10.1002\/hep.30628","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T10:48:43Z","timestamp":1553856523000},"page":"911-924","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":16,"title":["Abdominal Surgery in Patients With Idiopathic Noncirrhotic Portal Hypertension: A Multicenter Retrospective Study"],"prefix":"10.1097","volume":"70","author":[{"given":"Laure","family":"Elkrief","sequence":"first","affiliation":[{"name":"Service de Transplantation,H\u00f4pitaux Universitaires de Gen\u00e8ve,Geneva,Switzerland"},{"name":"Service d'H\u00e9pato\u2010Gastroent\u00e9rologie,H\u00f4pitaux Universitaires de Gen\u00e8ve,Geneva,Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8034-1291","authenticated-orcid":false,"given":"Jos\u00e9","family":"Ferrusquia\u2010Acosta","sequence":"additional","affiliation":[{"name":"Hepatic Hemodynamic Laboratory, European Reference Network for Rare Liver Disorders, Liver Unit,Hospital Clinic, IDIBAPS and CIBERehd,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Payanc\u00e9","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9patologie, Centre de R\u00e9f\u00e9rence des Maladies Vasculaires du Foie, DHU Unity, P\u00f4le des Maladies de l'Appareil Digestif,H\u00f4pital Beaujon, AP\u2010HP,Clichy,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Moga","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9pato\u2010Gastro\u2010Ent\u00e9rologie,CHU Toulouse,Toulouse,France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Tellez","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterolog\u00eda y Hepatolog\u00eda,Hospital Universitario Ramon y Cajal,Madrid,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Praktiknjo","sequence":"additional","affiliation":[{"name":"Laboratory for Liver Fibrosis and Portal Hypertension,Universitatsklinikum,Bonn,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Procopet","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, 3rd Medical Clinic,University of Medicine and Pharmacy \u201cluliu Hatieganu,\u201d Regional Institute 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