{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:06:32Z","timestamp":1791648392355,"version":"4.3.4"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n            <jats:title>Background and Aims<\/jats:title>\n            <jats:p>Exposure to metals may promote the risk for cancers. We evaluated the associations of a broad spectrum of metals with gallbladder cancer (GBC) and gallstones.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results<\/jats:title>\n            <jats:p>A total of 259 patients with GBC, 701 patients with gallstones, and 851 population\u2010based controls were enrolled in Shanghai, China. A metallome panel was used to simultaneously detect 18 metals in serum through inductively coupled plasma\u2013mass spectrometry. Logistic regression models were used to estimate crude or adjusted odds ratios (OR<jats:sub>adj<\/jats:sub>) with 95% confidence intervals (CIs) for the association between metal levels and gallbladder disease. Among the 18 metals tested, 12 were significantly associated with GBC and six with gallstones (<jats:italic toggle=\"yes\">P<\/jats:italic>\n                                 <jats:sub>corrected<\/jats:sub>\u00a0&lt;\u00a00.002). Boron, lithium, molybdenum, and arsenic levels were associated with GBC compared to gallstones as well as with gallstones compared to population\u2010based controls. Elevated levels of cadmium, chromium, copper, molybdenum, and vanadium were positively associated with GBC versus gallstones; and the OR<jats:sub>adj<\/jats:sub> for the highest tertile (T3) compared to the lowest tertile (T1) ranged from 1.80 to 7.28, with evidence of dose\u2013response trends (<jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.05). Arsenic, boron, iron, lithium, magnesium, selenium, and sulfur were inversely associated with GBC, with the T3 versus T1 OR<jats:sub>adj<\/jats:sub> ranging from 0.20 to 0.69. Arsenic, boron, calcium, lithium, molybdenum, and phosphorus were negatively associated with gallstones, with the T3 versus T1 OR<jats:sub>adj<\/jats:sub> ranging from 0.50 to 0.75 (<jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Metals were associated with both GBC and gallstones, providing cross\u2010sectional evidence of association across the natural history of disease. Longitudinal studies are needed to evaluate the temporality of metal exposure and gallbladder diseases and to investigate the mechanisms of disease pathogenesis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.30861","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T18:28:29Z","timestamp":1563474509000},"page":"917-928","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":52,"title":["A Metallomic Approach to Assess Associations of Serum Metal Levels With Gallstones and Gallbladder Cancer"],"prefix":"10.1097","volume":"71","author":[{"given":"Mei\u2010Hsuan","family":"Lee","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine,National Yang\u2010Ming University,Taipei,Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Tang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology,Shanghai Cancer Institute,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Han","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine,National Yang\u2010Ming University,Taipei,Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma E.","family":"McGee","sequence":"additional","affiliation":[{"name":"Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics,National Cancer Institute, National Institutes of Health,Rockville,MD"},{"name":"Department of Epidemiology,Harvard T.H. Chan School of Public Health,Boston,MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tram","family":"Lam","sequence":"additional","affiliation":[{"name":"Division of Cancer Control and Population Sciences, Epidemiology and Genomics Research Program,National Cancer Institute, National Institutes of Health,Rockville,MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingsheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Zhongshan Hospital,Fudan University,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Chang","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shanghai Cancer Center,Fudan University,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Pathology,MD Anderson Cancer Center,Houston,TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth M.","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Biostatistics Branch,National Cancer Institute, National Institutes of Health,Rockville,MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann W.","family":"Hsing","sequence":"additional","affiliation":[{"name":"Stanford Cancer Institute,Stanford University,Stanford,CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Koshiol","sequence":"additional","affiliation":[{"name":"Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics,National Cancer Institute, National Institutes of Health,Rockville,MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,11,1]]},"reference":[{"key":"hep30861-bib-0001-20250501","first-page":"99","article-title":"Gallbladder cancer: epidemiology and 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