{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T22:46:08Z","timestamp":1786488368743,"version":"build-2736575974"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n            <jats:title>Background and Aims<\/jats:title>\n            <jats:p>Biliary atresia (BA) is a devastating neonatal cholangiopathy that progresses to fibrosis and end\u2010stage liver disease by 2 years of age. Portoenterostomy may reestablish biliary drainage, but, despite drainage, virtually all afflicted patients develop fibrosis and progress to end\u2010stage liver disease requiring liver transplantation for survival.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results<\/jats:title>\n            <jats:p>In the murine model of BA, rhesus rotavirus (RRV) infection of newborn pups results in a cholangiopathy paralleling human BA and has been used to study mechanistic aspects of the disease. Unfortunately, nearly all RRV\u2010infected pups succumb by day of life 14. Thus, in this study we generated an RRV\u2010TUCH rotavirus reassortant (designated as T<jats:sup>R(VP2,VP4)<\/jats:sup>) that when injected into newborn mice causes an obstructive jaundice phenotype with lower mortality rates. Of the mice that survived, 63% developed Ishak stage 3\u20105 fibrosis with histopathological signs of inflammation\/fibrosis and bile duct obstruction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>This model of rotavirus\u2010induced neonatal fibrosis will provide an opportunity to study disease pathogenesis and has potential to be used in preclinical studies with an objective to identify therapeutic targets that may alter the course of BA.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.30907","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T19:43:55Z","timestamp":1566589435000},"page":"1316-1330","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":24,"title":["Rotavirus Reassortant\u2013Induced Murine Model of Liver Fibrosis Parallels Human Biliary Atresia"],"prefix":"10.1097","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8603-2876","authenticated-orcid":false,"given":"Sujit K.","family":"Mohanty","sequence":"first","affiliation":[{"name":"Department of Pediatric and Thoracic Surgery,Cincinnati Children\u2019s Hospital Medical Center,Cincinnati,OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Lobeck","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Thoracic Surgery,Cincinnati Children\u2019s Hospital Medical Center,Cincinnati,OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Thoracic Surgery,Cincinnati Children\u2019s Hospital Medical Center,Cincinnati,OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phylicia","family":"Dupree","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Thoracic Surgery,Cincinnati Children\u2019s Hospital Medical Center,Cincinnati,OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Walther","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Thoracic Surgery,Cincinnati Children\u2019s Hospital Medical Center,Cincinnati,OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Mowery","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Thoracic Surgery,Cincinnati Children\u2019s Hospital Medical Center,Cincinnati,OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Coots","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Thoracic Surgery,Cincinnati Children\u2019s Hospital Medical Center,Cincinnati,OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Bondoc","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Thoracic Surgery,Cincinnati Children\u2019s Hospital Medical Center,Cincinnati,OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M.","family":"Sheridan","sequence":"additional","affiliation":[{"name":"Division of Pathology and Laboratory Medicine,Cincinnati Children\u2019s Hospital Medical Center,Cincinnati,OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly M.","family":"Poling","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Thoracic Surgery,Cincinnati Children\u2019s Hospital Medical Center,Cincinnati,OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haley","family":"Temple","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Thoracic Surgery,Cincinnati Children\u2019s Hospital Medical Center,Cincinnati,OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"McNeal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,University of Cincinnati College of Medicine,Cincinnati,OH"},{"name":"Division of Infectious Diseases,Cincinnati Children\u2019s Hospital Medical Center,Cincinnati,OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karol","family":"Sestak","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center,Covington,LA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchi","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Science and Technology, Technical Medical Centre,University of Twente,Enschede,the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Tiao","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Thoracic Surgery,Cincinnati Children\u2019s Hospital Medical 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