{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:56:42Z","timestamp":1787313402807,"version":"build-2736575974"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T00:00:00Z","timestamp":1587600000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The Model for End\u2010Stage Liver Disease (MELD) is used for clinical decision\u2010making and organ allocation for orthotopic liver transplantation (OLT) and was previously upgraded through inclusion of serum sodium (Na) concentrations (MELD\u2010Na). However, MELD\u2010Na may underestimate complications arising from portal hypertension or infection. The von Willebrand factor (vWF) antigen (vWF\u2010Ag) correlates with portal pressure and seems capable of predicting complications in patients with cirrhosis. Accordingly, this study aimed to evaluate vWF\u2010Ag as an adjunct surrogate marker for risk stratification on the waiting list for OLT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach and Results<\/jats:title>\n                    <jats:p>\n                      Hence, WF\u2010Ag at time of listing was assessed in patients listed for OLT. Clinical characteristics, MELD\u2010Na, and mortality on the waiting list were recorded. Prediction of 3\u2010month waiting\u2010list survival was assessed by receiver operating characteristics and net reclassification improvement. Interestingly, patients dying within 3 months on the waiting list displayed elevated levels of vWF\u2010Ag (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). MELD\u2010Na and vWF\u2010Ag were comparable and independent in their predictive potential for 3\u2010month mortality on the waiting list (area under the curve [AUC], vWF\u2010Ag\u00a0=\u00a00.739; MELD\u2010Na\u00a0=\u00a00.764). Importantly, a vWF\u2010Ag cutoff at 413% identified patients at risk for death within 3 months of listing with a higher odds ratio (OR) than the previously published cutoff at a MELD\u2010Na of 20 points (vWF\u2010Ag, OR\u00a0=\u00a010.873, 95% confidence interval [CI], 3.160, 36.084; MELD\u2010Na, OR\u00a0=\u00a07.594, 95% CI, 2.578, 22.372;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001, respectively). Ultimately, inclusion of vWF\u2010Ag into the MELD\u2010Na equation significantly improved prediction of 3\u2010month waiting\u2010list mortality (AUC, MELD\u2010Na\u2013vWF\u00a0=\u00a00.804).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A single measurement of vWF\u2010Ag at listing for OLT predicts early mortality. Combining vWF\u2010Ag levels with MELD\u2010Na improves risk stratification and may help to prioritize organ allocation to decrease waiting\u2010list mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.31047","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T04:29:40Z","timestamp":1574828980000},"page":"584-594","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":26,"title":["The von Willebrand Factor Facilitates Model for End\u2010Stage Liver Disease\u2013Independent Risk Stratification on the Waiting List for Liver Transplantation"],"prefix":"10.1097","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0863-2876","authenticated-orcid":false,"given":"Georg P.","family":"Gy\u00f6ri","sequence":"first","affiliation":[{"name":"Division of Transplantation,Department of Surgery,Medical University of Vienna,General Hospital Vienna,Vienna,Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6700-9163","authenticated-orcid":false,"given":"David","family":"Pereyra","sequence":"additional","affiliation":[{"name":"Division of General Surgery,Department of Surgery,Medical University of Vienna,General Hospital Vienna,Vienna,Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Rumpf","sequence":"additional","affiliation":[{"name":"Division of General Surgery,Department of Surgery,Medical University of Vienna,General Hospital Vienna,Vienna,Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Hackl","sequence":"additional","affiliation":[{"name":"Division of Bioinformatics, Biocenter,Medical University of Innsbruck,Innsbruck,Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"K\u00f6ditz","sequence":"additional","affiliation":[{"name":"Division of General Surgery,Department of Surgery,Medical University of Vienna,General Hospital Vienna,Vienna,Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Ortmayr","sequence":"additional","affiliation":[{"name":"Division of General Surgery,Department of Surgery,Medical University of Vienna,General Hospital Vienna,Vienna,Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4590-3583","authenticated-orcid":false,"given":"Thomas","family":"Reiberger","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Department of Internal Medicine III,Medical University of Vienna,General Hospital Vienna,Vienna,Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Trauner","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Department of Internal Medicine III,Medical University of Vienna,General Hospital Vienna,Vienna,Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela A.","family":"Berlakovich","sequence":"additional","affiliation":[{"name":"Division of Transplantation,Department of Surgery,Medical University of Vienna,General Hospital Vienna,Vienna,Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4666-5337","authenticated-orcid":false,"given":"Patrick","family":"Starlinger","sequence":"additional","affiliation":[{"name":"Division of General Surgery,Department of Surgery,Medical University of Vienna,General Hospital Vienna,Vienna,Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,4,23]]},"reference":[{"key":"hep31047-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1056\/NEJMp1210159","article-title":"Liver transplantation\u2014a vision realized","volume":"367","year":"2012","journal-title":"N Engl J 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