{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:30:23Z","timestamp":1792114223894,"version":"4.4.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The paucity of data regarding the extent of hepatitis delta virus (HDV) associated health care burden in the United States is an important obstacle to assessing the cost\u2010effectiveness of potential intervention strategies. In this study, we characterized the health care use and cost burdens of HDV in the United States using real\u2010world claims data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach and Results<\/jats:title>\n                    <jats:p>\n                      We conducted a case\u2010control study using the Truven Health MarketScan Commercial Claims databases from 2011\u20102014. A total of 2,727 HDV cases were matched 1:1 by sociodemographic characteristics and comorbidities to chronic hepatitis B virus (HBV) controls using propensity scores. The HDV group had significantly higher prevalence of substance abuse, sexually transmitted diseases, decompensated cirrhosis, cirrhosis, and hepatitis C virus compared to patients with chronic HBV. First HDV diagnosis was associated with significant increases in the total number of health care claims (25.61 vs. 28.99;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) and total annual health care costs ($19,476 vs. $23,605;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) compared with pre\u2010HDV baseline. The case\u2010control analysis similarly indicated higher total claims (28.99 vs. 25.19;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) and health care costs ($23,605 vs. $18,228;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) in HDV compared with HBV alone. Compared with HBV controls, HDV cases had an adjusted incident rate ratio of 1.16 (95% confidence interval: 1.10, 1.22) times the total number of annual claims and an adjusted incident rate ratio 1.32 (95% confidence interval 1.17, 1.48) times the total annual health care cost.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HDV is associated with higher health care use and cost burden than HBV alone, underscoring the need for improved screening and treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.31055","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T08:54:36Z","timestamp":1575536076000},"page":"399-411","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":30,"title":["Economic and Health Care Burdens of Hepatitis Delta: A Study of Commercially Insured Adults in the United States"],"prefix":"10.1097","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7963-2438","authenticated-orcid":false,"given":"Mohamed I.","family":"Elsaid","sequence":"first","affiliation":[{"name":"Department of Medicine,Division of Gastroenterology and Hepatology,Rutgers Robert Wood Johnson Medical School,New Brunswick,NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8758-0770","authenticated-orcid":false,"given":"You","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine,Division of Gastroenterology and Hepatology,Rutgers Robert Wood Johnson Medical School,New Brunswick,NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4506-1275","authenticated-orcid":false,"given":"Tina","family":"John","sequence":"additional","affiliation":[{"name":"Department of Medicine,Division of Gastroenterology and Hepatology,Rutgers Robert Wood Johnson Medical School,New Brunswick,NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navaneeth","family":"Narayanan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice,Ernest Mario School of Pharmacy,Rutgers The State University of New Jersey,Piscataway,NJ"},{"name":"Division of Infectious Diseases,Rutgers Robert Wood Johnson Medical School,New Brunswick,NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Catalano","sequence":"additional","affiliation":[{"name":"Department of Medicine,Division of Gastroenterology and Hepatology,Rutgers Robert Wood Johnson Medical School,New Brunswick,NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4105-5783","authenticated-orcid":false,"given":"Vinod K.","family":"Rustgi","sequence":"additional","affiliation":[{"name":"Department of Medicine,Division of Gastroenterology and 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