{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:05:01Z","timestamp":1788822301890,"version":"build-2803163510"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T00:00:00Z","timestamp":1605916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T00:00:00Z","timestamp":1605916800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1002\/hep.31396","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T17:38:03Z","timestamp":1591119483000},"page":"2235-2238","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Severe Refractory Checkpoint Inhibitor\u2010Related Hepatitis Reversed With Anti\u2010Thymocyte Globulin and n\u2010Acetylcysteine"],"prefix":"10.1097","volume":"72","author":[{"given":"Douglas","family":"Motomura","sequence":"first","affiliation":[{"name":"Department of Medicine,Queen\u2019s University,Kingston,Ontario,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Baetz","sequence":"additional","affiliation":[{"name":"Department of Oncology,Queen\u2019s University,Kingston,Ontario,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Grin","sequence":"additional","affiliation":[{"name":"Department of Pathology,Queen\u2019s University,Kingston,Ontario,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Flemming","sequence":"additional","affiliation":[{"name":"Department of Medicine,Queen\u2019s University,Kingston,Ontario,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,11,21]]},"reference":[{"key":"hep31396-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1200\/JCO.2017.77.6385","article-title":"Management of immune\u2010related adverse events in patients treated with immune checkpoint inhibitor therapy: American Society of Clinical Oncology Clinical Practice Guideline","volume":"36","year":"2018","journal-title":"J Clin Oncol"},{"key":"hep31396-bib-0002-20241017","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1200\/JCO.2010.32.2206","article-title":"Resolution of severe ipilimumab\u2010induced hepatitis after antithymocyte globulin therapy","volume":"29","year":"2011","journal-title":"J Clin Oncol"},{"key":"hep31396-bib-0003-20241017","article-title":"Resolution of ipilimumab induced severe hepatotoxicity with triple immunosuppressants therapy","volume":"2015","year":"2015","journal-title":"BMJ Case Rep"},{"key":"hep31396-bib-0004-20241017","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00262-017-2107-7","article-title":"Anti\u2010PD\u20101\u2010induced high\u2010grade hepatitis associated with corticosteroid\u2010resistant T cells: a case report","volume":"67","year":"2018","journal-title":"Cancer Immunol Immunother"},{"key":"hep31396-bib-0005-20241017","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jhep.2016.11.015","article-title":"Managing immune checkpoint\u2010inhibitor\u2010induced severe autoimmune\u2010like hepatitis by liver\u2010directed topical steroids","volume":"66","year":"2017","journal-title":"J Hepatol"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.31396","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hep.31396","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hep.31396","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1002\/hep.31396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:04:50Z","timestamp":1729209890000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1002\/hep.31396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,21]]},"references-count":5,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.31396","relation":{},"ISSN":["0270-9139","1527-3350"],"issn-type":[{"value":"0270-9139","type":"print"},{"value":"1527-3350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,21]]},"assertion":[{"value":"2020-02-07","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}