{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:11:19Z","timestamp":1790428279870,"version":"4.1.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1002\/hep.31407","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T01:40:52Z","timestamp":1591321252000},"page":"753-769","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":38,"title":["Immunosuppressive Treatment Regimens in Autoimmune Hepatitis: Systematic Reviews and Meta\u2010Analyses Supporting American Association for the Study of Liver Diseases Guidelines"],"prefix":"10.1097","volume":"72","author":[{"given":"John M.","family":"Vierling","sequence":"first","affiliation":[{"name":"Departments of Medicine and Surgery,Baylor College of Medicine,Houston,TX,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanda","family":"Kerkar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,University of Rochester School of Medicine,Rochester,NY,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert J.","family":"Czaja","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Mayo Clinic College of Medicine,Rochester,MN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara L.","family":"Mack","sequence":"additional","affiliation":[{"name":"Department of Pediatrics,Children's Hospital Colorado,University of Colorado School of Medicine,Aurora,CO,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6776-0336","authenticated-orcid":false,"given":"David","family":"Adams","sequence":"additional","affiliation":[{"name":"College of Medical and Dental Sciences,University of Birmingham,Birmingham,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Assis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,Yale University School of Medicine,New Haven,CT,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Manns","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Endocrinology,Hannover Medical School,Hannover,Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlyn J.","family":"Mayo","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center,Dallas,TX,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Nayfeh","sequence":"additional","affiliation":[{"name":"Mayo Clinic Evidence\u2010Based Practice Research Program,Rochester,MN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Mounaem M.","family":"Majzoub","sequence":"additional","affiliation":[{"name":"Mayo Clinic Evidence\u2010Based Practice Research Program,Rochester,MN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muayad A.","family":"Alzuabi","sequence":"additional","affiliation":[{"name":"Mayo Clinic Evidence\u2010Based Practice Research Program,Rochester,MN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Ding","sequence":"additional","affiliation":[{"name":"Mayo Clinic Evidence\u2010Based Practice Research Program,Rochester,MN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Haffar","sequence":"additional","affiliation":[{"name":"Mayo Clinic Evidence\u2010Based Practice Research Program,Rochester,MN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Hassan","family":"Murad","sequence":"additional","affiliation":[{"name":"Mayo Clinic Evidence\u2010Based Practice Research Program,Rochester,MN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouaz","family":"Alsawas","sequence":"additional","affiliation":[{"name":"Mayo Clinic Evidence\u2010Based Practice Research Program,Rochester,MN,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"key":"hep31407-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1002\/hep.23584","article-title":"Diagnosis and management of autoimmune hepatitis","volume":"51","year":"2010","journal-title":"Hepatology"},{"key":"hep31407-bib-0002-20241017","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1136\/gut.2010.235259","article-title":"British Society of Gastroenterology (BSG) guidelines for management of autoimmune hepatitis","volume":"60","year":"2011","journal-title":"Gut"},{"key":"hep31407-bib-0003-20241017","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.jhep.2015.06.030","article-title":"EASL clinical practice guidelines: autoimmune hepatitis","volume":"63","year":"2015","journal-title":"J Hepatol"},{"key":"hep31407-bib-0004-20241017","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/oxfordjournals.qjmed.a067264","article-title":"Controlled prospective trial of corticosteroid therapy in active chronic hepatitis","volume":"40","year":"1971","journal-title":"Q J Med"},{"key":"hep31407-bib-0005-20241017","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S0016-5085(19)33223-8","article-title":"Clinical, biochemical, and histological remission of severe chronic active liver disease: a controlled study of treatments and early prognosis","volume":"63","year":"1972","journal-title":"Gastroenterology"},{"key":"hep31407-bib-0006-20241017","first-page":"735","article-title":"Controlled trial of prednisone and azathioprine in active chronic hepatitis","volume":"1","year":"1973","journal-title":"Lancet"},{"key":"hep31407-bib-0007-20241017","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1055\/s-2001-13708","article-title":"Long\u2010term management and prognosis of autoimmune hepatitis (AIH): a single center experience","volume":"39","year":"2001","journal-title":"Z Gastroenterol"},{"key":"hep31407-bib-0008-20241017","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0168-8278(05)80005-4","article-title":"Survival and histological resolution of fibrosis in patients with autoimmune chronic active hepatitis","volume":"18","year":"1993","journal-title":"J Hepatol"},{"key":"hep31407-bib-0009-20241017","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.jhep.2004.01.009","article-title":"Decreased fibrosis during corticosteroid therapy of autoimmune hepatitis","volume":"40","year":"2004","journal-title":"J Hepatol"},{"key":"hep31407-bib-0010-20241017","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/apt.12592","article-title":"Review article: prevention and reversal of hepatic fibrosis in autoimmune hepatitis","volume":"39","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"hep31407-bib-0011-20241017","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/hep.1840040409","article-title":"Complete resolution of inflammatory activity following corticosteroid treatment of HBsAg\u2010negative chronic active hepatitis","volume":"4","year":"1984","journal-title":"Hepatology"},{"key":"hep31407-bib-0012-20241017","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1053\/jhep.2002.32485","article-title":"Sustained remission after corticosteroid therapy for type 1 autoimmune hepatitis: a retrospective analysis","volume":"35","year":"2002","journal-title":"Hepatology"},{"key":"hep31407-bib-0013-20241017","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1111\/j.1440-1746.2008.05365.x","article-title":"Favorable outcomes of autoimmune hepatitis in a community clinic setting","volume":"23","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"hep31407-bib-0014-20241017","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jhep.2012.09.009","article-title":"Relapse is almost universal after withdrawal of immunosuppressive medication in patients with autoimmune hepatitis in remission","volume":"58","year":"2013","journal-title":"J Hepatol"},{"key":"hep31407-bib-0015-20241017","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1111\/apt.12701","article-title":"Review article: permanent drug withdrawal is desirable and achievable for autoimmune hepatitis","volume":"39","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"hep31407-bib-0016-20241017","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1053\/j.gastro.2011.02.065","article-title":"Long\u2010term outcomes of patients with autoimmune hepatitis managed at a nontransplant center","volume":"140","year":"2011","journal-title":"Gastroenterology"},{"key":"hep31407-bib-0017-20241017","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/hep.21787","article-title":"Features associated with treatment failure in type 1 autoimmune hepatitis and predictive value of the model of end\u2010stage liver disease","volume":"46","year":"2007","journal-title":"Hepatology"},{"key":"hep31407-bib-0018-20241017","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1002\/hep.23840","article-title":"Treatment response in patients with autoimmune hepatitis","volume":"52","year":"2010","journal-title":"Hepatology"},{"key":"hep31407-bib-0019-20241017","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1007\/s10620-012-2179-3","article-title":"Diagnosis, pathogenesis, and treatment of autoimmune hepatitis after liver transplantation","volume":"57","year":"2012","journal-title":"Dig Dis Sci"},{"key":"hep31407-bib-0020-20241017","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/lt.25375","article-title":"Recurrent and de novo autoimmune hepatitis","volume":"25","year":"2019","journal-title":"Liver Transpl"},{"key":"hep31407-bib-0021-20241017","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1002\/hep.23924","article-title":"Application of the 2010 American Association for the Study of Liver Diseases criteria of remission to a cohort of Italian patients with autoimmune hepatitis","volume":"52","year":"2010","journal-title":"Hepatology"},{"key":"hep31407-bib-0022-20241017","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/apt.14968","article-title":"Inequity of care provision and outcome disparity in autoimmune hepatitis in the United Kingdom","volume":"48","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"hep31407-bib-0023-20241017","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1007\/s11605-010-1256-1","article-title":"Living donor and deceased donor liver transplantation for autoimmune and cholestatic liver diseases\u2014an analysis of the UNOS database","volume":"14","year":"2010","journal-title":"J Gastrointest Surg"},{"key":"hep31407-bib-0024-20241017","first-page":"e83","article-title":"Liver transplantation for children with primary sclerosing cholangitis and autoimmune hepatitis: UNOS database analysis","volume":"64","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"hep31407-bib-0025-20241017","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1097\/00007890-199812270-00013","article-title":"Outcome of autoimmune hepatitis after liver transplantation","volume":"66","year":"1998","journal-title":"Transplantation"},{"key":"hep31407-bib-0026-20241017","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1002\/lt.21525","article-title":"Liver transplantation for autoimmune hepatitis and the success of aggressive corticosteroid withdrawal","volume":"14","year":"2008","journal-title":"Liver Transpl"},{"key":"hep31407-bib-0027-20241017","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/lt.21796","article-title":"Risk factors for recurrence of autoimmune hepatitis after liver transplantation","volume":"15","year":"2009","journal-title":"Liver Transpl"},{"key":"hep31407-bib-0028-20241017","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1432-2277.2007.00628.x","article-title":"The impact of disease recurrence on graft survival following liver transplantation: a single centre experience","volume":"21","year":"2008","journal-title":"Transpl Int"},{"key":"hep31407-bib-0029-20241017","article-title":"Diagnosis and management of autoimmune hepatitis in adults and children: 2019 practice guidance and guidelines from the American Association for the Study of Liver Diseases","year":"2019","journal-title":"Hepatology"},{"key":"hep31407-bib-0030-20241017","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta\u2010analyses: the PRISMA statement","volume":"339","year":"2009","journal-title":"BMJ"},{"key":"hep31407-bib-0033-20241017","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta\u2010analysis in clinical trials","volume":"7","year":"1986","journal-title":"Control Clin Trials"},{"key":"hep31407-bib-0034-20241017","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta\u2010analysis","volume":"21","year":"2002","journal-title":"Stat Med"},{"key":"hep31407-bib-0035-20241017","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/jrsm.12","article-title":"A basic introduction to fixed\u2010effect and random\u2010effects models for meta\u2010analysis","volume":"1","year":"2010","journal-title":"Res Synth Methods"},{"key":"hep31407-bib-0036-20241017","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1001\/jama.2014.5559","article-title":"How to read a systematic review and meta\u2010analysis and apply the results to patient care: users' guides to the medical literature","volume":"312","year":"2014","journal-title":"JAMA"},{"key":"hep31407-bib-0037-20241017","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1053\/j.gastro.2010.06.046","article-title":"Budesonide induces remission more effectively than prednisone in a controlled trial of patients with autoimmune hepatitis","volume":"139","year":"2010","journal-title":"Gastroenterology"},{"key":"hep31407-bib-0038-20241017","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.jpeds.2013.05.042","article-title":"European Autoimmune Hepatitis\u2010Budesonide Study Group. Budesonide versus prednisone with azathioprine for the treatment of autoimmune hepatitis in children and adolescents","volume":"163","year":"2013","journal-title":"J Pediatr"},{"key":"hep31407-bib-0039-20241017","first-page":"55","article-title":"Prospective survey of health and socioeconomical characteristics of 249 patients with autoimmune hepatitis","volume":"31","year":"2013","journal-title":"Verdauungskrankheiten"},{"key":"hep31407-bib-0040-20241017","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/1751-2980.12085","article-title":"Autoimmune hepatitis in southern Israel: a 15\u2010year multicenter study","volume":"14","year":"2013","journal-title":"J Dig Dis"},{"key":"hep31407-bib-0041-20241017","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/j.1478-3231.2005.01107.x","article-title":"Transplant immunosuppressive agents in non\u2010transplant chronic autoimmune hepatitis: the Canadian Association for the Study of Liver (CASL) experience with mycophenolate mofetil and tacrolimus","volume":"25","year":"2005","journal-title":"Liver Int"},{"key":"hep31407-bib-0042-20241017","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1016\/j.cgh.2017.06.001","article-title":"Efficacy and safety of mycophenolate mofetil and tacrolimus as second\u2010line therapy for patients with autoimmune hepatitis","volume":"15","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"hep31407-bib-0043-20241017","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.cgh.2008.04.006","article-title":"A single center review of the use of mycophenolate mofetil in the treatment of autoimmune hepatitis","volume":"6","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"hep31407-bib-0044-20241017","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1007\/s10620-018-5011-x","article-title":"Tacrolimus and mycophenolate mofetil as second\u2010line therapies for pediatric patients with autoimmune hepatitis","volume":"63","year":"2018","journal-title":"Dig Dis Sci"},{"key":"hep31407-bib-0045-20241017","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/j.transproceed.2005.03.145","article-title":"Withdrawal of steroids: a randomized prospective study of prednisone and tacrolimus versus mycophenolate mofetil and tacrolimus in liver transplant recipients with autoimmune hepatitis","volume":"37","year":"2005","journal-title":"Transplant Proc"},{"key":"hep31407-bib-0046-20241017","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/lt.500050514","article-title":"Successful withdrawal of prednisone after adult liver transplantation for autoimmune hepatitis","volume":"5","year":"1999","journal-title":"Liver Transpl Surg"},{"key":"hep31407-bib-0047-20241017","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1016\/S0041-1345(02)03570-4","article-title":"Autoimmune hepatitis following liver transplantation: relationship to recurrent disease and steroid weaning","volume":"34","year":"2002","journal-title":"Transplant Proc"},{"key":"hep31407-bib-0049-20241017","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/apt.13907","article-title":"Expert clinical management of autoimmune hepatitis in the real world","volume":"45","year":"2017","journal-title":"Aliment Pharmacol Ther"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.31407","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hep.31407","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hep.31407","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1002\/hep.31407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T23:57:23Z","timestamp":1729209443000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1002\/hep.31407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.31407","relation":{},"ISSN":["0270-9139","1527-3350"],"issn-type":[{"value":"0270-9139","type":"print"},{"value":"1527-3350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"2020-03-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-26","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}