{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:29:08Z","timestamp":1788478148225,"version":"build-2803163510"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n            <jats:title>Background and Aims<\/jats:title>\n            <jats:p>In December 2019, an outbreak of coronavirus disease 2019 (COVID\u201019) emerged in Wuhan, China. Although it has been reported that some patients with COVID\u201019 showed elevated liver biochemistries, there are few studies regarding the clinical features and prognosis of these patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results<\/jats:title>\n            <jats:p>In this multicenter, retrospective study, we collected data on laboratory\u2010confirmed patients with COVID\u201019 from three hospitals in Wuhan, China, who died or were discharged between February 1, 2020, and February 20, 2020. Data on demographics, comorbidities, clinical symptoms, laboratory examinations on admission, complications, treatment, and outcome were collected. A total of 482 patients were enrolled in this study. Of those, 142 (29.5%) patients showed abnormal liver biochemistries on admission, and patients with elevated alanine aminotransferase, aspartate aminotransferase (AST), and total bilirubin (TBIL) accounted for 67.6%, 69.0%, and 16.2%, respectively. Those with abnormal liver biochemistries showed higher percentages of severe cases and comorbidities and were more likely to have dyspnea, chest distress or pain, and increased hemoglobin (Hb) on admission. Higher rates of complications and mortality and worse recovery when discharged were observed in patients with abnormal AST or TBIL. Multivariable regression analysis showed that chest distress or pain (odds ratio [OR], 1.765; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.018), dyspnea (OR, 2.495; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.001), elevated C\u2010reactive protein level (OR, 1.007; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.008), elevated white blood count (OR, 1.139; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.013), and elevated Hb concentration (OR, 1.024; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.001) were independent factors associated with elevated liver biochemistries in patients with COVID\u201019.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Elevated liver biochemistries were common in patients with COVID\u201019. Patients with hypoxia or severe inflammation are more likely to experience increased liver biochemistries on admission. Those with abnormal AST or TBIL on admission are more likely to suffer from severe complications and death.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.31446","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T04:50:09Z","timestamp":1593492609000},"page":"1509-1520","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":70,"title":["Clinical Features of Patients Infected With Coronavirus Disease 2019 With Elevated Liver Biochemistries: A Multicenter, Retrospective Study"],"prefix":"10.1097","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8878-3131","authenticated-orcid":false,"given":"Yu","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology,Union Hospital,Tongji Medical College,Huazhong University of Science and 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Technology,Wuhan,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9887-9388","authenticated-orcid":false,"given":"Qin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4950-2648","authenticated-orcid":false,"given":"Mengjia","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3022-2336","authenticated-orcid":false,"given":"Xiaofeng","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7626-5983","authenticated-orcid":false,"given":"Xi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7536-4939","authenticated-orcid":false,"given":"Runze","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8495-2185","authenticated-orcid":false,"given":"Chaoyue","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology,Union 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