{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T22:11:34Z","timestamp":1783807894153,"version":"3.55.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1002\/hep.31484","type":"journal-article","created":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T07:35:33Z","timestamp":1596267333000},"page":"2219-2227","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":26,"title":["Functional Role of the Secretin\/Secretin Receptor Signaling During Cholestatic Liver Injury"],"prefix":"10.1097","volume":"72","author":[{"given":"Nan","family":"Wu","sequence":"first","affiliation":[{"name":"Hepatology and Gastroenterology, Medicine,Indiana University,Indianapolis,IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Baiocchi","sequence":"additional","affiliation":[{"name":"Liver Unit,Department of Medicine,University of Rome \u201cTor Vergata,\u201d,Rome,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology,Texas A&M University,Bryan,TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Hepatology and Gastroenterology, Medicine,Indiana University,Indianapolis,IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica","family":"Ceci","sequence":"additional","affiliation":[{"name":"Hepatology and Gastroenterology, Medicine,Indiana University,Indianapolis,IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanyin","family":"Meng","sequence":"additional","affiliation":[{"name":"Hepatology and Gastroenterology, Medicine,Indiana University,Indianapolis,IN"},{"name":"Gastroenterology, Medicine,Richard L. Roudebush VA Medical Center and Indiana University,Indianapolis,IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisaku","family":"Sato","sequence":"additional","affiliation":[{"name":"Hepatology and Gastroenterology, Medicine,Indiana University,Indianapolis,IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaodong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nutrition,Texas A&M University,College Station,TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0741-8007","authenticated-orcid":false,"given":"Burcin","family":"Ekser","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery,Department of Surgery,Indiana University School of Medicine,Indianapolis,IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7424-2788","authenticated-orcid":false,"given":"Konstantina","family":"Kyritsi","sequence":"additional","affiliation":[{"name":"Hepatology and Gastroenterology, Medicine,Indiana University,Indianapolis,IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debjyoti","family":"Kundu","sequence":"additional","affiliation":[{"name":"Hepatology and Gastroenterology, Medicine,Indiana University,Indianapolis,IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixian","family":"Chen","sequence":"additional","affiliation":[{"name":"Hepatology and Gastroenterology, Medicine,Indiana University,Indianapolis,IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vik","family":"Meadows","sequence":"additional","affiliation":[{"name":"Hepatology and Gastroenterology, Medicine,Indiana University,Indianapolis,IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Franchitto","sequence":"additional","affiliation":[{"name":"Eleonora Lorillard Spencer Cenci Foundation,Rome,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Alvaro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties,Rome,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Onori","sequence":"additional","affiliation":[{"name":"Department of Anatomical,Histological,Forensic Medicine and Orthopedics Sciences,Sapienza University of Rome,Rome,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Gaudio","sequence":"additional","affiliation":[{"name":"Department of Anatomical,Histological,Forensic Medicine and Orthopedics Sciences,Sapienza University of Rome,Rome,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Lenci","sequence":"additional","affiliation":[{"name":"Liver Unit,Department of Medicine,University of Rome \u201cTor Vergata,\u201d,Rome,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Francis","sequence":"additional","affiliation":[{"name":"Hepatology and Gastroenterology, Medicine,Indiana University,Indianapolis,IN"},{"name":"Gastroenterology, Medicine,Richard L. Roudebush VA Medical Center and Indiana University,Indianapolis,IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Glaser","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology,Texas A&M University,Bryan,TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Alpini","sequence":"additional","affiliation":[{"name":"Hepatology and Gastroenterology, Medicine,Indiana University,Indianapolis,IN"},{"name":"Gastroenterology, Medicine,Richard L. Roudebush VA Medical Center and Indiana University,Indianapolis,IN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"hep31484-bib-0001-20241017","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cld.2018.03.013","article-title":"Role of bile acids and the biliary HCO3(\u2010) umbrella in the pathogenesis of primary biliary cholangitis","volume":"22","year":"2018","journal-title":"Clin Liver Dis"},{"key":"hep31484-bib-0002-20241017","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41575-019-0132-z","article-title":"Neonatal cholestasis: emerging molecular diagnostics and potential novel therapeutics","volume":"16","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"hep31484-bib-0003-20241017","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1053\/gast.1996.v110.pm8613073","article-title":"Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver","volume":"110","year":"1996","journal-title":"Gastroenterology"},{"key":"hep31484-bib-0004-20241017","doi-asserted-by":"crossref","first-page":"G922","DOI":"10.1152\/ajpgi.1994.266.5.G922","article-title":"Upregulation of secretin receptor gene expression in rat cholangiocytes after bile duct ligation","volume":"266","year":"1994","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"hep31484-bib-0005-20241017","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1172\/JCI113355","article-title":"Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules","volume":"81","year":"1988","journal-title":"J Clin Invest"},{"key":"hep31484-bib-0006-20241017","doi-asserted-by":"crossref","first-page":"G612","DOI":"10.1152\/ajpgi.2001.281.3.G612","article-title":"Regulation of cholangiocyte bicarbonate secretion","volume":"281","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"hep31484-bib-0007-20241017","doi-asserted-by":"crossref","first-page":"10269","DOI":"10.1096\/fj.201802606R","article-title":"Secretin\/secretin receptor signaling mediates biliary damage and liver fibrosis in early\u2010stage primary biliary cholangitis","volume":"33","year":"2019","journal-title":"Faseb J"},{"key":"hep31484-bib-0008-20241017","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41374-018-0045-4","article-title":"An impaired biliary bicarbonate umbrella may be involved in dysregulated autophagy in primary biliary cholangitis","volume":"98","year":"2018","journal-title":"Lab Invest"},{"key":"hep31484-bib-0009-20241017","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0300-5089(21)00474-0","article-title":"Secretin","volume":"9","year":"1980","journal-title":"Clin Gastroenterol"},{"key":"hep31484-bib-0010-20241017","doi-asserted-by":"crossref","first-page":"15961","DOI":"10.1073\/pnas.0903695106","article-title":"Secretin as a neurohypophysial factor regulating body water homeostasis","volume":"106","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"hep31484-bib-0011-20241017","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.regpep.2006.02.011","article-title":"Signaling mechanisms of secretin receptor","volume":"137","year":"2006","journal-title":"Regul Pept"},{"key":"hep31484-bib-0012-20241017","doi-asserted-by":"crossref","first-page":"15523","DOI":"10.1016\/S0021-9258(19)49566-5","article-title":"Secretin stimulates exocytosis in isolated bile duct epithelial cells by a cyclic AMP\u2010mediated mechanism","volume":"267","year":"1992","journal-title":"J Biol Chem"},{"key":"hep31484-bib-0013-20241017","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/hep.22926","article-title":"Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation","volume":"50","year":"2009","journal-title":"Hepatology"},{"key":"hep31484-bib-0014-20241017","doi-asserted-by":"crossref","first-page":"G289","DOI":"10.1152\/ajpgi.1997.272.2.G289","article-title":"Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation","volume":"272","year":"1997","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"hep31484-bib-0015-20241017","doi-asserted-by":"crossref","first-page":"G767","DOI":"10.1152\/ajpgi.1998.274.4.G767","article-title":"Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation","volume":"274","year":"1998","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"hep31484-bib-0016-20241017","doi-asserted-by":"crossref","first-page":"G1064","DOI":"10.1152\/ajpgi.1997.272.5.G1064","article-title":"Large but not small intrahepatic bile ducts are involved in secretin\u2010regulated ductal bile secretion","volume":"272","year":"1997","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"hep31484-bib-0017-20241017","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0016-5085(99)70242-8","article-title":"Bile acid feeding induces cholangiocyte proliferation and secretion: evidence for bile acid\u2010regulated ductal secretion","volume":"116","year":"1999","journal-title":"Gastroenterology"},{"key":"hep31484-bib-0018-20241017","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.3748\/wjg.v12.i22.3553","article-title":"Bile acid interactions with cholangiocytes","volume":"12","year":"2006","journal-title":"World J Gastroenterol"},{"key":"hep31484-bib-0019-20241017","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/hep.20653","article-title":"Secretin activation of the apical Na+\u2010dependent bile acid transporter is associated with cholehepatic shunting in rats","volume":"41","year":"2005","journal-title":"Hepatology"},{"key":"hep31484-bib-0020-20241017","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1074\/jbc.M110.164970","article-title":"Identification and functional characterization of TMEM16A, a Ca2+\u2010activated Cl\u2010 channel activated by extracellular nucleotides, in biliary epithelium","volume":"286","year":"2011","journal-title":"J Biol Chem"},{"key":"hep31484-bib-0021-20241017","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1002\/hep.23883","article-title":"Adenosine triphosphate release and purinergic (P2) receptor\u2010mediated secretion in small and large mouse cholangiocytes","volume":"52","year":"2010","journal-title":"Hepatology"},{"key":"hep31484-bib-0022-20241017","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1152\/physrev.00039.2011","article-title":"Structure and function of TMEM16 proteins (anoctamins)","volume":"94","year":"2014","journal-title":"Physiol Rev"},{"key":"hep31484-bib-0023-20241017","doi-asserted-by":"crossref","first-page":"G1289","DOI":"10.1152\/ajpgi.1999.276.5.G1289","article-title":"Acute carbon tetrachloride feeding induces damage of large but not small cholangiocytes from BDL rat liver","volume":"276","year":"1999","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"hep31484-bib-0024-20241017","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/hep.30150","article-title":"Ductular reaction in liver diseases: pathological mechanisms and translational significances","volume":"69","year":"2019","journal-title":"Hepatology"},{"key":"hep31484-bib-0025-20241017","doi-asserted-by":"crossref","first-page":"G124","DOI":"10.1152\/ajpgi.1989.257.1.G124","article-title":"Bile secretory function of intrahepatic biliary epithelium in the rat","volume":"257","year":"1989","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"hep31484-bib-0026-20241017","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.jhep.2004.06.009","article-title":"cAMP stimulates the secretory and proliferative capacity of the rat intrahepatic biliary epithelium through changes in the PKA\/Src\/MEK\/ERK1\/2 pathway","volume":"41","year":"2004","journal-title":"J Hepatol"},{"key":"hep31484-bib-0027-20241017","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1053\/j.gastro.2014.02.030","article-title":"Secretin stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice","volume":"146","year":"2014","journal-title":"Gastroenterology"},{"key":"hep31484-bib-0028-20241017","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/hep.23657","article-title":"Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation","volume":"52","year":"2010","journal-title":"Hepatology"},{"key":"hep31484-bib-0029-20241017","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1053\/jhep.2002.34741","article-title":"Intracellular pathways mediating estrogen\u2010induced cholangiocyte proliferation in the rat","volume":"36","year":"2002","journal-title":"Hepatology"},{"key":"hep31484-bib-0030-20241017","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00281-009-0164-5","article-title":"Primary biliary cirrhosis","volume":"31","year":"2009","journal-title":"Semin Immunopathol"},{"key":"hep31484-bib-0031-20241017","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.jhep.2009.11.027","article-title":"Primary biliary cirrhosis: a 2010 update","volume":"52","year":"2010","journal-title":"J Hepatol"},{"key":"hep31484-bib-0032-20241017","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1002\/hep.25829","article-title":"Deletion of interleukin (IL)\u201012p35 induces liver fibrosis in dominant\u2010negative TGFbeta receptor type II mice","volume":"57","year":"2013","journal-title":"Hepatology"},{"key":"hep31484-bib-0033-20241017","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1002\/hep.23810","article-title":"The biliary HCO(3)(\u2010) umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies","volume":"52","year":"2010","journal-title":"Hepatology"},{"key":"hep31484-bib-0034-20241017","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1053\/j.gastro.2008.02.020","article-title":"Ae2a, b\u2010deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis","volume":"134","year":"2008","journal-title":"Gastroenterology"},{"key":"hep31484-bib-0035-20241017","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/hep.22591","article-title":"Differential mechanisms in the pathogenesis of autoimmune cholangitis versus inflammatory bowel disease in interleukin\u20102Ralpha(\u2010\/\u2010) mice","volume":"49","year":"2009","journal-title":"Hepatology"},{"key":"hep31484-bib-0036-20241017","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/hep.28641","article-title":"Chronic expression of interferon\u2010gamma leads to murine autoimmune cholangitis with a female predominance","volume":"64","year":"2016","journal-title":"Hepatology"},{"key":"hep31484-bib-0037-20241017","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.jhep.2014.02.006","article-title":"Characterization of animal models for primary sclerosing cholangitis (PSC)","volume":"60","year":"2014","journal-title":"J Hepatol"},{"key":"hep31484-bib-0038-20241017","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1053\/j.gastro.2004.04.009","article-title":"Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice","volume":"127","year":"2004","journal-title":"Gastroenterology"},{"key":"hep31484-bib-0039-20241017","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s13244-013-0243-y","article-title":"Hepatobiliary anomalies associated with ABCB4\/MDR3 deficiency in adults: a pictorial essay","volume":"4","year":"2013","journal-title":"Insights Imaging"},{"key":"hep31484-bib-0040-20241017","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/hep.28622","article-title":"The secretin\/secretin receptor axis modulates liver fibrosis through changes in transforming growth factor\u2010\u03b21 biliary secretion in mice","volume":"64","year":"2016","journal-title":"Hepatology"},{"key":"hep31484-bib-0041-20241017","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cbi.2018.07.008","article-title":"New insights into TGF\u2010\u03b2\/Smad signaling in tissue fibrosis","volume":"292","year":"2018","journal-title":"Chem Biol Interact"},{"key":"hep31484-bib-0042-20241017","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1038\/s41374-018-0093-9","article-title":"Knockout of secretin receptor reduces biliary damage and liver fibrosis in Mdr2(\u2010\/\u2010) mice by diminishing senescence of cholangiocytes","volume":"98","year":"2018","journal-title":"Lab Invest"},{"key":"hep31484-bib-0043-20241017","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0016-5085(99)70564-0","article-title":"Assessment of biliary bicarbonate secretion in humans by positron emission tomography","volume":"117","year":"1999","journal-title":"Gastroenterology"},{"key":"hep31484-bib-0044-20241017","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/hep.25691","article-title":"Up\u2010regulation of microRNA 506 leads to decreased Cl\u2010\/HCO3 \u2010 anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis","volume":"56","year":"2012","journal-title":"Hepatology"},{"key":"hep31484-bib-0045-20241017","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/mt.2014.220","article-title":"Let\u20107 microRNAs regenerate peripheral nerve regeneration by targeting nerve growth factor","volume":"23","year":"2015","journal-title":"Mol Ther"},{"key":"hep31484-bib-0046-20241017","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0022-3468(84)80278-X","article-title":"Stimulation of bile output by gastrointestinal hormones following portoenterostomy for biliary atresia","volume":"19","year":"1984","journal-title":"J Pediatr Surg"},{"key":"hep31484-bib-0047-20241017","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/jamasurg.2013.5137","article-title":"Treatment and prognosis for patients with intrahepatic cholangiocarcinoma: systematic review and meta\u2010analysis","volume":"149","year":"2014","journal-title":"JAMA Surg"},{"key":"hep31484-bib-0048-20241017","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/ijc.25028","article-title":"Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP\u2010dependent signaling mechanisms of secretin receptor","volume":"127","year":"2010","journal-title":"Int J Cancer"},{"key":"hep31484-bib-0049-20241017","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1096\/fj.13-247536","article-title":"Secretin receptor\u2010knockout mice are resistant to high\u2010fat diet\u2010induced obesity and exhibit impaired intestinal lipid absorption","volume":"28","year":"2014","journal-title":"FASEB J"},{"key":"hep31484-bib-0050-20241017","first-page":"288","article-title":"Biliary atresia due to delayed maturation of the gut hormones' system? Introducing a new treatment modality","volume":"32","year":"2004","journal-title":"J Perinat Med"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.31484","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hep.31484","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hep.31484","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1002\/hep.31484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:03:25Z","timestamp":1729209805000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1002\/hep.31484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,19]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.31484","relation":{},"ISSN":["0270-9139","1527-3350"],"issn-type":[{"value":"0270-9139","type":"print"},{"value":"1527-3350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,19]]},"assertion":[{"value":"2020-05-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}