{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T10:52:11Z","timestamp":1792839131762,"version":"4.5.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Although terlipressin and albumin are effective at treating acute kidney injury\u2010hepatorenal syndrome (AKI\u2010HRS), liver transplantation (LT) is the best treatment. However, it is unclear if an effective treatment with terlipressin and albumin improves post\u2010LT outcomes in these patients. The aim of this study was to evaluate the impact of response to treatment with terlipressin and albumin on posttransplant outcomes in patients with AKI\u2010HRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach and Results<\/jats:title>\n                    <jats:p>\n                      We analyzed two cohorts of patients with cirrhosis listed for LT between 2012 and 2016: 82 patients who developed AKI\u2010HRS before LT and were treated with terlipressin and albumin and 259 patients without AKI\u2010HRS who received transplants during the study period (control group). After LT, patients were followed up until discharge, every month for the first 3 months, and every 3\u00a0months thereafter. Of the patients, 43 (52%) responded to terlipressin and albumin. Responders had a better 30\u2010day transplant\u2010free survival (60% vs. 33%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a00.006), longer LT waiting list time (37 vs. 17\u00a0days,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a00.041), and lower Model for End\u2010Stage Liver Disease score at the time of LT (23 vs. 29,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a00.007). Among patients with AKI\u2010HRS receiving transplant, nonresponders required renal replacement therapy (RRT) more frequently than responders (20% vs. 0%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a00.024). Nonresponders had a significantly higher incidence of chronic kidney disease (CKD) at 1 year after LT than responders (65% vs. 31%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a00.019). In multivariate analysis, nonresponse to terlipressin and albumin was found to be an independent predictor for CKD at 1 year after LT (subdistribution hazard ratio [SHR]\u00a0=\u00a02.76,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a00.001), whereas responders did not have an increased risk (SHR\u00a0=\u00a01.53,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a00.210).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with AKI\u2010HRS, response to terlipressin and albumin reduces the need for RRT after LT and reduces the risk of CKD at 1 year after LT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.31529","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T16:12:08Z","timestamp":1598976728000},"page":"1909-1919","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":81,"title":["Response to Terlipressin and Albumin Is Associated With Improved Liver Transplant Outcomes in Patients With Hepatorenal Syndrome"],"prefix":"10.1097","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9356-5830","authenticated-orcid":false,"given":"Salvatore","family":"Piano","sequence":"first","affiliation":[{"name":"Unit of Internal Medicine and Hepatology,Department of Medicine,University of Padova,Padova,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9376-1527","authenticated-orcid":false,"given":"Carmine","family":"Gambino","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine and Hepatology,Department of Medicine,University of Padova,Padova,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elia","family":"Vettore","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine and Hepatology,Department of Medicine,University of Padova,Padova,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Calvino","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine and Hepatology,Department of Medicine,University of Padova,Padova,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Tonon","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine and Hepatology,Department of Medicine,University of Padova,Padova,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Boccagni","sequence":"additional","affiliation":[{"name":"Hepatobiliary Surgery and Liver Transplantation,Department of Surgery, Oncology and Gastroenterology,University of Padova,Padova,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3459-7306","authenticated-orcid":false,"given":"Enrico","family":"Gringeri","sequence":"additional","affiliation":[{"name":"Hepatobiliary Surgery and Liver Transplantation,Department of Surgery, Oncology and Gastroenterology,University of Padova,Padova,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Germani","sequence":"additional","affiliation":[{"name":"Multivisceral Transplant Unit,Department of Surgery, Oncology and Gastroenterology,University of Padova,Padova,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Burra","sequence":"additional","affiliation":[{"name":"Multivisceral Transplant Unit,Department of Surgery, Oncology and Gastroenterology,University of Padova,Padova,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Cillo","sequence":"additional","affiliation":[{"name":"Hepatobiliary Surgery and Liver Transplantation,Department of Surgery, Oncology and Gastroenterology,University of Padova,Padova,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Angeli","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine and Hepatology,Department of Medicine,University of Padova,Padova,Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"key":"hep31529-bib-0001-20250824","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.jhep.2019.07.002","article-title":"News in pathophysiology, definition and classification of hepatorenal syndrome: a step beyond the International Club of Ascites (ICA) consensus document","volume":"71","year":"2019","journal-title":"J 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