{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:34:07Z","timestamp":1791498847240,"version":"4.3.4"},"reference-count":82,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T00:00:00Z","timestamp":1618272000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>Osteopontin (OPN) was first identified in 1986. The prefix osteo\u2010 means bone; however, OPN is expressed in other tissues, including liver. The suffix \u2010pontin means bridge and denotes the role of OPN as a link protein within the extracellular matrix. While OPN has well\u2010established physiological roles, multiple \u201comics\u201d analyses suggest that it is also involved in chronic liver disease. In this review, we provide a summary of the OPN gene and protein structure and regulation. We outline the current knowledge on how OPN is involved in hepatic steatosis in the context of alcoholic liver disease and non\u2010alcoholic fatty liver disease. We describe the mechanisms whereby OPN participates in inflammation and liver fibrosis and discuss current research on its role in hepatocellular carcinoma and cholangiopathies. To conclude, we highlight important points to consider when doing research on OPN and provide direction for making progress on how OPN contributes to chronic liver disease.<\/jats:p>","DOI":"10.1002\/hep.31582","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T14:21:11Z","timestamp":1601302871000},"page":"1594-1608","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":201,"title":["Osteopontin Takes Center Stage in Chronic Liver Disease"],"prefix":"10.1097","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5101-3950","authenticated-orcid":false,"given":"Zhuolun","family":"Song","sequence":"first","affiliation":[{"name":"Department of Pathology,University of Illinois at Chicago,Chicago,IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology,University of Illinois at Chicago,Chicago,IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipti","family":"Athavale","sequence":"additional","affiliation":[{"name":"Department of Pathology,University of Illinois at Chicago,Chicago,IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Pathology,University of Illinois at Chicago,Chicago,IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Desert","sequence":"additional","affiliation":[{"name":"Department of Pathology,University of Illinois at Chicago,Chicago,IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukanta","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Pathology,University of Illinois at Chicago,Chicago,IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology,University of Illinois at Chicago,Chicago,IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7941-6804","authenticated-orcid":false,"given":"Natalia","family":"Nieto","sequence":"additional","affiliation":[{"name":"Department of Pathology,University of Illinois at Chicago,Chicago,IL"},{"name":"Department of Medicine,Division of Gastroenterology and Hepatology,University of Illinois at Chicago,Chicago,IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"hep31582-bib-0001-20250825","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bbcan.2017.02.005","article-title":"Osteopontin splice variants and polymorphisms in cancer progression and prognosis","volume":"1868","year":"2017","journal-title":"Biochim Biophys Acta Rev 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