{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:19:13Z","timestamp":1784067553656,"version":"3.55.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n            <jats:title>Background and Aims<\/jats:title>\n            <jats:p>Increasing evidence in recent years has suggested that microRNA\u20107 (miR\u20107) is an important gene implicated in the development of various diseases including HCC. However, the role of miR\u20107 in autoimmune hepatitis (AIH) is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results<\/jats:title>\n            <jats:p>Herein, we showed that miR\u20107 deficiency led to exacerbated pathology in Concanavalin\u2010A\u2010induced murine acute autoimmune liver injury (ALI) model, accompanied by hyperactivation state of CD4<jats:sup>+<\/jats:sup> T cells. Depletion of CD4<jats:sup>+<\/jats:sup> T cells reduced the effect of miR\u20107 deficiency on the pathology of ALI. Interestingly, miR\u20107 deficiency elevated CD4<jats:sup>+<\/jats:sup> T\u2010cell activation, proliferation, and cytokine production <jats:italic toggle=\"yes\">in vitro<\/jats:italic>. Adoptive cell transfer experiments showed that miR\u20107<jats:italic toggle=\"yes\">\n                                    def\n                                 <\/jats:italic> CD4<jats:sup>+<\/jats:sup> T cells could exacerbate the pathology of ALI. Further analysis showed that miR\u20107 expression was up\u2010regulated in activated CD4<jats:sup>+<\/jats:sup> T cells. Importantly, the transcription of pre\u2010miR\u20107b, a major resource of mature miR\u20107 in CD4<jats:sup>+<\/jats:sup> T cells, was dominantly dependent on transcription factor CCAAT enhancer binding protein alpha (C\/EBP\u03b1), which binds to the core promoter region of the <jats:italic toggle=\"yes\">miR\u20107b<\/jats:italic> gene. Global gene analysis showed that mitogen\u2010activated protein kinase 4 (MAPK4) is a target of miR\u20107 in CD4<jats:sup>+<\/jats:sup> T cells. Finally, the loss of MAPK4 could ameliorate the activation state of CD4<jats:sup>+<\/jats:sup> T cells with or without miR\u20107 deficiency. Our studies document the important role of miR\u20107 in the setting of AIH induced by Concanavalin\u2010A. Specifically, we provide evidence that the C\/EBP\u03b1\/miR\u20107 axis negatively controls CD4<jats:sup>+<\/jats:sup> T\u2010cell activation and function through MAPK4, thereby orchestrating experimental AIH in\u2002mice.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>This study expands on the important role of miR\u20107 in liver\u2010related diseases and reveals the value of the C\/EBP\u03b1\/miR\u20107 axis in CD4<jats:sup>+<\/jats:sup> T\u2010cell biological function for the pathogenesis of immune\u2010mediated liver diseases.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.31607","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T15:57:10Z","timestamp":1604073430000},"page":"379-396","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":38,"title":["C\/EBP\u03b1\/miR\u20107 Controls CD4+ T\u2010Cell Activation and Function and Orchestrates Experimental Autoimmune Hepatitis in Mice"],"prefix":"10.1097","volume":"74","author":[{"given":"Juanjuan","family":"Zhao","sequence":"first","affiliation":[{"name":"Special Key Laboratory of Gene Detection & Therapy of Guizhou Province,Zunyi Medical University,Zunyi,China"},{"name":"Department of Immunology,Zunyi Medical University,Zunyi,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyun","family":"Chu","sequence":"additional","affiliation":[{"name":"Special Key Laboratory of Gene Detection & Therapy of Guizhou Province,Zunyi Medical University,Zunyi,China"},{"name":"Department of Immunology,Zunyi Medical University,Zunyi,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualin","family":"Xu","sequence":"additional","affiliation":[{"name":"Special Key Laboratory of Gene Detection & Therapy of Guizhou Province,Zunyi Medical University,Zunyi,China"},{"name":"Department of Immunology,Zunyi Medical University,Zunyi,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Special Key Laboratory of Gene Detection & Therapy of Guizhou Province,Zunyi Medical University,Zunyi,China"},{"name":"Department of Immunology,Zunyi Medical University,Zunyi,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine,Shanghai Jiao Tong University Affiliated Sixth People's Hospital,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Special Key Laboratory of Gene Detection & Therapy of Guizhou Province,Zunyi Medical University,Zunyi,China"},{"name":"Department of Immunology,Zunyi Medical 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