{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:39:06Z","timestamp":1789141146230,"version":"build-2803163510"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n            <jats:title>Background and Aims<\/jats:title>\n            <jats:p>Gastrointestinal (GI) malignancies are common after liver transplantation. The aim of this study was to identify the risk and timing of the more common GI malignancies, colorectal and pancreatic cancer, to aid in optimizing potential posttransplant screening practices.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results<\/jats:title>\n            <jats:p>Data from the United Network for Organ Sharing database of all adult liver\u2010transplant recipients from 1997 to 2017 were analyzed and a comparison made with cancer incidence from general population data using Surveillance, Epidemiology, and End Results data. Of 866 <jats:italic toggle=\"yes\">de novo<\/jats:italic> GI malignancies, 405 colorectal and 216 pancreas were identified. The highest cumulative incidence for colorectal cancer occurred in recipients with primary sclerosing cholangitis (PSC), recipients over the age of 50 with non\u2010alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC)\/cholangiocarcinoma (CCA), and females &gt;50\u00a0years with alcohol\u2010associated liver disease and HCC\/CCA, with risk increasing above the general population within 5\u00a0years of transplant. Patients with PSC and HCC\/CCA or NASH and HCC\/CCA have the highest cumulative incidence of pancreatic cancer also rising within 5 years following transplant, with those patients &gt;50\u00a0years old conferring the highest risk.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>These data identify a high\u2010risk cohort that warrants consideration for intensified individualized screening practices for colorectal cancer after liver transplantation. In addition to recipients with PSC, further study of recipients with NASH and HCC\/CCA and females with alcohol\u2010associated liver disease and HCC\/CCA may be better tailored to colorectal cancer screening ideals. Higher\u2010risk patient populations for pancreatic cancer (PSC and NASH with HCC\/CCA) would benefit from further study to determine potential screening practices. GI malignancies occur at higher rates in liver\u2010transplant patients compared with the general population. In the era of individualized medicine, this study identifies the highest\u2010risk transplant recipients (PSC and NASH cirrhosis with coexisting HCC\/CCA) who may benefit from altered screening practices for these malignancies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.31731","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T13:16:44Z","timestamp":1612531004000},"page":"1003-1013","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":19,"title":["De Novo Colorectal and Pancreatic Cancer in Liver\u2010Transplant Recipients: Identifying the Higher\u2010Risk Populations"],"prefix":"10.1097","volume":"74","author":[{"given":"Navine","family":"Nasser\u2010Ghodsi","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Mayo 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