{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:33:58Z","timestamp":1792506838410,"version":"4.5.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n            <jats:title>Background and Aims<\/jats:title>\n            <jats:p>Antifibrotic therapy remains an unmet medical need in human chronic liver disease. We report the antifibrotic properties of cytoglobin (CYGB), a respiratory protein expressed in hepatic stellate cells (HSCs), the main cell type involved in liver fibrosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results<\/jats:title>\n            <jats:p>\n                                 <jats:italic toggle=\"yes\">Cygb<\/jats:italic>\u2010deficient mice that had bile duct ligation\u2013induced liver cholestasis or choline\u2010deficient amino acid\u2013defined diet\u2013induced steatohepatitis significantly exacerbated liver damage, fibrosis, and reactive oxygen species (ROS) formation. All of these manifestations were attenuated in <jats:italic toggle=\"yes\">Cygb<\/jats:italic>\u2010overexpressing mice. We produced hexa histidine\u2013tagged recombinant human CYGB (His\u2010CYGB), traced its biodistribution, and assessed its function in HSCs or in mice with advanced liver cirrhosis using thioacetamide (TAA) or 3,5\u2010diethoxycarbonyl\u20101,4\u2010dihydrocollidine (DDC). In cultured HSCs, extracellular His\u2010CYGB was endocytosed and accumulated in endosomes through a clathrin\u2010mediated pathway. His\u2010CYGB significantly impeded ROS formation spontaneously or in the presence of ROS inducers in HSCs, thus leading to the attenuation of collagen type 1 alpha 1 production and \u03b1\u2010smooth muscle actin expression. Replacement the iron center of the heme group with cobalt nullified the effect of His\u2010CYGB. In addition, His\u2010CYGB induced interferon\u2010\u03b2 secretion by HSCs that partly contributed to its antifibrotic function. Momelotinib incompletely reversed the effect of His\u2010CYGB. Intravenously injected His\u2010CYGB markedly suppressed liver inflammation, fibrosis, and oxidative cell damage in mice administered TAA or DDC mice without adverse effects. RNA\u2010sequencing analysis revealed the down\u2010regulation of inflammation\u2010 and fibrosis\u2010related genes and the up\u2010regulation of antioxidant genes in both cell culture and liver tissues. The injected His\u2010CYGB predominantly localized to HSCs but not to macrophages, suggesting specific targeting effects. His\u2010CYGB exhibited no toxicity in chimeric mice with humanized livers.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>His\u2010CYGB could have antifibrotic clinical applications for human chronic liver diseases.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.31752","type":"journal-article","created":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T23:53:38Z","timestamp":1613260418000},"page":"2527-2545","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":34,"title":["Hexa Histidine\u2013Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species"],"prefix":"10.1097","volume":"73","author":[{"given":"Ninh Quoc","family":"Dat","sequence":"first","affiliation":[{"name":"Department of Hepatology,Graduate School of Medicine,Osaka City University,Osaka,Japan"},{"name":"Department of Pediatrics,Hanoi Medical University,Hanoi,Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Thi Thanh","family":"Thuy","sequence":"additional","affiliation":[{"name":"Department of Hepatology,Graduate School of Medicine,Osaka City University,Osaka,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vu Ngoc","family":"Hieu","sequence":"additional","affiliation":[{"name":"Department of Hepatology,Graduate School of Medicine,Osaka City University,Osaka,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang","family":"Hai","sequence":"additional","affiliation":[{"name":"Department of Hepatology,Graduate School of Medicine,Osaka City University,Osaka,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinh Viet","family":"Hoang","sequence":"additional","affiliation":[{"name":"Department of Hepatology,Graduate School of Medicine,Osaka City University,Osaka,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen","family":"Thi Thanh Hai","sequence":"additional","affiliation":[{"name":"Department of Biochemistry,Hanoi Medical University,Hanoi,Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuong Thi Van","family":"Thuy","sequence":"additional","affiliation":[{"name":"Biological Resources Vinmec Tissue Bank,Vinmec Healthcare System,Hanoi,Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Komiya","sequence":"additional","affiliation":[{"name":"Department of Biology,Faculty of Science,Osaka City University,Osaka,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista","family":"Rombouts","sequence":"additional","affiliation":[{"name":"Regenerative Medicine and Fibrosis Group,Institute for Liver and Digestive Health,University College London,Royal Free Hospital,London,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh Phuong","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Hepatology,Graduate School of Medicine,Osaka City University,Osaka,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngo Vinh","family":"Hanh","sequence":"additional","affiliation":[{"name":"Department of Hepatology,Graduate School of Medicine,Osaka City University,Osaka,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Truong Huu","family":"Hoang","sequence":"additional","affiliation":[{"name":"Department of Hepatology,Graduate School of Medicine,Osaka City University,Osaka,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misako","family":"Sato\u2010Matsubara","sequence":"additional","affiliation":[{"name":"Department of Hepatology,Graduate School of Medicine,Osaka City University,Osaka,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Daikoku","sequence":"additional","affiliation":[{"name":"Department of Hepatology,Graduate School of Medicine,Osaka City University,Osaka,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiho","family":"Kadono","sequence":"additional","affiliation":[{"name":"Department of Hepatology,Graduate School of Medicine,Osaka City University,Osaka,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Oikawa","sequence":"additional","affiliation":[{"name":"Department of Pathobiochemistry,Graduate School of Medicine,Osaka City University,Osaka,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsutoshi","family":"Yoshizato","sequence":"additional","affiliation":[{"name":"Academic Advisor\u2019s Office,PhoenixBio Co., Ltd.,Hiroshima,Japan"},{"name":"Endowed Laboratory of Synthetic Biology,Graduate School of Medicine,Osaka City University,Osaka,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuminori","family":"Tokunaga","sequence":"additional","affiliation":[{"name":"Department of Pathobiochemistry,Graduate School of Medicine,Osaka City University,Osaka,Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Pinzani","sequence":"additional","affiliation":[{"name":"Regenerative Medicine and Fibrosis Group,Institute for Liver and Digestive Health,University College London,Royal Free Hospital,London,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norifumi","family":"Kawada","sequence":"additional","affiliation":[{"name":"Department of Hepatology,Graduate School of Medicine,Osaka City University,Osaka,Japan"},{"name":"Regenerative Medicine and Fibrosis Group,Institute for Liver and Digestive Health,University College London,Royal Free Hospital,London,United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,5,22]]},"reference":[{"key":"hep31752-bib-0001-20250824","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","year":"2008","journal-title":"Gastroenterology"},{"key":"hep31752-bib-0002-20250824","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/B978-0-12-385233-5.00006-4","article-title":"Fibrosis in the liver: acute protection and chronic disease","volume":"97","year":"2010","journal-title":"Prog Mol Biol Transl Sci"},{"key":"hep31752-bib-0003-20250824","first-page":"185","article-title":"Effect of CCl\u20104 in vitro and in vivo on lipid peroxidation of rat liver homogenates and subcellular fractions","volume":"29","year":"1965","journal-title":"Enzymologia"},{"key":"hep31752-bib-0004-20250824","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/0024-3205(65)90173-6","article-title":"Positive evidence of acceleration of lipoperoxidation in rat liver by carbon tetrachloride: In vitro experiments","volume":"4","year":"1965","journal-title":"Life Sci"},{"key":"hep31752-bib-0005-20250824","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/hep.1840160225","article-title":"Increased 4\u2010hydroxynonenal levels in experimental alcoholic liver disease: association of lipid peroxidation with liver fibrogenesis","volume":"16","year":"1992","journal-title":"Hepatology"},{"key":"hep31752-bib-0006-20250824","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","year":"2018","journal-title":"Nat Med"},{"key":"hep31752-bib-0007-20250824","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/0016-5085(94)90237-2","article-title":"Excess iron into hepatocytes is required for activation of collagen type I gene during experimental siderosis","volume":"107","year":"1994","journal-title":"Gastroenterology"},{"key":"hep31752-bib-0008-20250824","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/hep.510230625","article-title":"Hepatocyte proliferative activity in chronic liver damage as assessed by the monoclonal antibody MIB1 Ki67 in archival material: the role of etiology, disease activity, iron, and lipid peroxidation","volume":"23","year":"1996","journal-title":"Hepatology"},{"key":"hep31752-bib-0009-20250824","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.jhep.2012.05.024","article-title":"Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis","volume":"57","year":"2012","journal-title":"J Hepatol"},{"key":"hep31752-bib-0010-20250824","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/10715760100300281","article-title":"Invited review: Manganese superoxide dismutase in disease","volume":"34","year":"2001","journal-title":"Free Radic Res"},{"key":"hep31752-bib-0011-20250824","first-page":"223","article-title":"Hepatic stellate cells and oxidative stress","volume":"99","year":"2007","journal-title":"Rev Esp Enferm Dig"},{"key":"hep31752-bib-0012-20250824","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-pathol-011110-130246","article-title":"Pathogenesis of liver fibrosis","volume":"6","year":"2011","journal-title":"Annu Rev Pathol"},{"key":"hep31752-bib-0013-20250824","doi-asserted-by":"crossref","first-page":"25318","DOI":"10.1074\/jbc.M102630200","article-title":"Characterization of a stellate cell activation\u2010associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells","volume":"276","year":"2001","journal-title":"J Biol Chem"},{"key":"hep31752-bib-0014-20250824","first-page":"257","article-title":"Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases","volume":"31","year":"2016","journal-title":"Histol Histopathol"},{"key":"hep31752-bib-0015-20250824","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.redox.2018.07.019","article-title":"The effect of reactive oxygen and nitrogen species on the structure of cytoglobin: a potential tumor suppressor","volume":"19","year":"2018","journal-title":"Redox Biol"},{"key":"hep31752-bib-0016-20250824","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.ajpath.2014.12.017","article-title":"Cytoglobin deficiency promotes liver cancer development from hepatosteatosis through activation of the oxidative stress pathway","volume":"185","year":"2015","journal-title":"Am J Pathol"},{"key":"hep31752-bib-0017-20250824","doi-asserted-by":"crossref","first-page":"24990","DOI":"10.1038\/srep24990","article-title":"Absence of cytoglobin promotes multiple organ abnormalities in aged mice","volume":"6","year":"2016","journal-title":"Sci Rep"},{"key":"hep31752-bib-0018-20250824","doi-asserted-by":"crossref","first-page":"17860","DOI":"10.1038\/s41598-018-36215-4","article-title":"Selective overexpression of cytoglobin in stellate cells attenuates thioacetamide\u2010induced liver fibrosis in mice","volume":"8","year":"2018","journal-title":"Sci Rep"},{"key":"hep31752-bib-0019-20250824","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jhep.2012.01.029","article-title":"STAT proteins \u2010 key regulators of anti\u2010viral responses, inflammation, and tumorigenesis in the liver","volume":"57","year":"2012","journal-title":"J Hepatol"},{"key":"hep31752-bib-0020-20250824","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1365-2567.2007.02672.x","article-title":"Interferon\u2010beta reduces the mouse liver fibrosis induced by repeated administration of concanavalin A via the direct and indirect effects","volume":"122","year":"2007","journal-title":"Immunology"},{"key":"hep31752-bib-0021-20250824","doi-asserted-by":"crossref","first-page":"41888","DOI":"10.1038\/srep41888","article-title":"Possible Involvement of nitric oxide in enhanced liver injury and fibrogenesis during cholestasis in cytoglobin\u2010deficient mice","volume":"7","year":"2017","journal-title":"Sci Rep"},{"key":"hep31752-bib-0022-20250824","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/labinvest.2013.135","article-title":"Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver","volume":"94","year":"2014","journal-title":"Lab Invest"},{"key":"hep31752-bib-0023-20250824","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.ajpath.2011.05.006","article-title":"Promotion of liver and lung tumorigenesis in DEN\u2010treated cytoglobin\u2010deficient mice","volume":"179","year":"2011","journal-title":"Am J Pathol"},{"key":"hep31752-bib-0024-20250824","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00441-011-1246-y","article-title":"TGF\u2010\u03b2 in progression of liver disease","volume":"347","year":"2012","journal-title":"Cell Tissue Res"},{"key":"hep31752-bib-0025-20250824","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jinorgbio.2004.11.009","article-title":"Neuroglobin and cytoglobin in search of their role in the vertebrate globin family","volume":"99","year":"2005","journal-title":"J Inorg Biochem"},{"key":"hep31752-bib-0026-20250824","doi-asserted-by":"crossref","first-page":"14807","DOI":"10.1038\/ncomms14807","article-title":"Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall","volume":"8","year":"2017","journal-title":"Nat Commun"},{"key":"hep31752-bib-0027-20250824","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nri3581","article-title":"Regulation of type I interferon responses","volume":"14","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"hep31752-bib-0028-20250824","article-title":"IRF and STAT Transcription factors \u2010 from basic biology to roles in infection, protective immunity, and primary immunodeficiencies","volume":"9","year":"2019","journal-title":"Front Immunol"},{"key":"hep31752-bib-0029-20250824","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.3892\/ol.2012.931","article-title":"Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients","volume":"4","year":"2012","journal-title":"Oncol Lett"},{"key":"hep31752-bib-0030-20250824","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrd2399","article-title":"Protein therapeutics: a summary and pharmacological classification","volume":"7","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"hep31752-bib-0031-20250824","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","year":"2005","journal-title":"J Clin Invest"},{"key":"hep31752-bib-0032-20250824","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1177\/20.9.672","article-title":"The use of exogenous myoglobin as an ultrastructural tracer. Reabsorption and translocation of protein by the renal tubule","volume":"20","year":"1972","journal-title":"J Histochem Cytochem"},{"key":"hep31752-bib-0033-20250824","first-page":"1123","article-title":"Glomerular permeability. Ultrastructural cytochemical studies using peroxidases as protein tracers","volume":"124","year":"1966","journal-title":"J Exp Med"},{"key":"hep31752-bib-0034-20250824","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jhep.2020.03.051","article-title":"TGF\u2010beta1\u2010driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non\u2010alcoholic steatohepatitis","volume":"73","year":"2020","journal-title":"J Hepatol"},{"key":"hep31752-bib-0035-20250824","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1124\/jpet.102.038968","article-title":"Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione","volume":"303","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"hep31752-bib-0036-20250824","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1046\/j.1365-2036.2001.01083.x","article-title":"Plasma transforming growth factor\u2010beta1 level and efficacy of alpha\u2010tocopherol in patients with non\u2010alcoholic steatohepatitis: a pilot study","volume":"15","year":"2001","journal-title":"Aliment Pharmacol Ther"},{"key":"hep31752-bib-0037-20250824","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nrd2422","article-title":"Interferons at age 50: past, current and future impact on biomedicine","volume":"6","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"hep31752-bib-0038-20250824","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1089\/10799900050151102","article-title":"Early clearance of circulating hepatitis C virus enhanced by induction therapy with twice\u2010a\u2010day intravenous injection of IFN\u2010beta","volume":"20","year":"2000","journal-title":"J Interferon Cytokine Res"},{"key":"hep31752-bib-0039-20250824","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/hep.26981","article-title":"Toll\u2010like receptor 7\u2010mediated type I interferon signaling prevents cholestasis\u2010 and hepatotoxin\u2010induced liver fibrosis","volume":"60","year":"2014","journal-title":"Hepatology"},{"key":"hep31752-bib-0040-20250824","first-page":"1154","article-title":"Effect of interferon on incidence of hepatocellular carcinoma in patients with chronic hepatitis C","volume":"52","year":"2005","journal-title":"Hepatogastroenterology"},{"key":"hep31752-bib-0041-20250824","article-title":"Cellular reactive oxygen species inhibit MPYS induction of IFNbeta","volume":"5","year":"2010","journal-title":"PLoS One"},{"key":"hep31752-bib-0042-20250824","doi-asserted-by":"crossref","first-page":"23508","DOI":"10.1038\/srep23508","article-title":"The effect of rhCygb on CCl4\u2010induced hepatic fibrogenesis in rat","volume":"6","year":"2016","journal-title":"Sci Rep"},{"key":"hep31752-bib-0043-20250824","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2174\/157016312799304570","article-title":"Mice with liver composed of human hepatocytes as an animal model for drug testing","volume":"9","year":"2012","journal-title":"Curr Drug Discov Technol"},{"key":"hep31752-bib-0044-20250824","first-page":"823","article-title":"Hemoglobin \u2010 a novel ligand of hepatocyte ectopic F1\u2010ATPase","volume":"66","year":"2015","journal-title":"J Physiol Pharmacol"}],"updated-by":[{"DOI":"10.1002\/hep.32767","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000}}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hep.31752","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hep.31752","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1002\/hep.31752","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:04:51Z","timestamp":1756080291000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1002\/hep.31752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,22]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.31752","relation":{},"ISSN":["0270-9139","1527-3350"],"issn-type":[{"value":"0270-9139","type":"print"},{"value":"1527-3350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,22]]},"assertion":[{"value":"2020-12-02","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}