{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:44:36Z","timestamp":1791999876039,"version":"4.4.0"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:p>Pulmonary disease in liver cirrhosis and portal hypertension (PH) constitutes a challenging clinical scenario and may have important implications with regard to prognosis, liver transplantation (LT) candidacy, and post\u2010LT outcome. Pre\u2010LT evaluation should include adequate screening for pulmonary diseases that may occur concomitantly with liver disease as well as for those that may arise as a complication of end\u2010stage liver disease and PH, given that either may jeopardize safe LT and successful outcome. It is key to discriminate those patients who would benefit from LT, especially pulmonary disorders that have been reported to resolve post\u2010LT and are considered \u201cpulmonary indications\u201d for transplant, from those who are at increased mortality risk and in whom LT is contraindicated. In conclusion, in this article, we review the impact of several pulmonary disorders, including cystic fibrosis, alpha 1\u2010antitrypsin deficiency, hereditary hemorrhagic telangiectasia, sarcoidosis, coronavirus disease 2019, asthma, chronic obstructive pulmonary disease, pulmonary nodules, interstitial lung disease, hepatic hydrothorax, hepatopulmonary syndrome, and portopulmonary hypertension, on post\u2010LT survival, as well as the reciprocal impact of LT on the evolution of lung function.<\/jats:p>","DOI":"10.1002\/hep.31770","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T12:00:48Z","timestamp":1614340848000},"page":"1674-1686","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":30,"title":["Pulmonary Abnormalities in Liver Disease: Relevance to Transplantation and Outcome"],"prefix":"10.1097","volume":"74","author":[{"given":"Sarah","family":"Raevens","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Ghent University\u2010Ghent University Hospital,Ghent,Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxine","family":"Boret","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Ghent University\u2010Ghent University Hospital,Ghent,Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"De Pauw","sequence":"additional","affiliation":[{"name":"Department of Cardiology,Ghent University\u2010Ghent University Hospital,Ghent,Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Fallon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,University of Arizona College of Medicine,Phoenix,AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Van Vlierberghe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology,Ghent University\u2010Ghent University Hospital,Ghent,Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,5,24]]},"reference":[{"key":"hep31770-bib-0003-20250824","first-page":"24","article-title":"Assessment of liver disease in cystic fibrosis","volume":"27","year":"2018","journal-title":"Paediatr Respir Rev"},{"key":"hep31770-bib-0004-20250824","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1136\/adc.68.5.653","article-title":"Liver cirrhosis in cystic fibrosis\u2014therapeutic implications and long term follow up","volume":"68","year":"1993","journal-title":"Arch Dis Child"},{"key":"hep31770-bib-0005-20250824","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/j.1432-2277.2006.00344.x","article-title":"Liver transplant in cystic fibrosis: a poll among European centers. 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