{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T02:04:24Z","timestamp":1775786664180,"version":"3.50.1"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>The 2020 Nobel Prize in Medicine or Physiology was awarded to Drs. Harvey Alter, Michael Houghton, and Charles Rice for their contributions to the discovery and characterization of the hepatitis C virus (HCV). Their achievements represent a remarkable triumph of biomedical science which allowed the development of curative therapy for HCV, that will save countless lives. This tribute provides a historical perspective of the laureates' seminal work leading to the discovery of the HCV and a synopsis of a forum hosted by the American Association for the Study of Liver Diseases to honor the laureates in which they offered their perspectives, advice for young investigators and what's left to accomplish in the field. Finally, others in the research community who have worked closely with one or more of the laureates, share some of their personal reflections and anecdotes.<\/jats:p>","DOI":"10.1002\/hep.31830","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T12:05:06Z","timestamp":1617105906000},"page":"2813-2823","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["The 2020 Nobel Prize for Medicine or Physiology for the Discovery of Hepatitis C Virus: A Triumph of Curiosity and Persistence"],"prefix":"10.1097","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2837-0188","authenticated-orcid":false,"given":"Marc G.","family":"Ghany","sequence":"first","affiliation":[{"name":"Liver Diseases Branch,National Institutes of Diabetes and Digestive and Kidney Diseases,National Institutes of Health,Bethesda,MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna S.F.","family":"Lok","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,University of Michigan,Ann Arbor,MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7024-0980","authenticated-orcid":false,"given":"Jules L.","family":"Dienstag","sequence":"additional","affiliation":[{"name":"Gastrointestinal Unit,Massachusetts General Hospital,Boston,MA"},{"name":"Department of Medicine,Harvard Medical School,Boston,MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Feinstone","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch,National Institutes of Diabetes and Digestive and Kidney Diseases,National Institutes of Health,Bethesda,MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay H.","family":"Hoofnagle","sequence":"additional","affiliation":[{"name":"Liver Diseases Research Branch,National Institutes of Diabetes and Digestive and Kidney Diseases,National Institutes of Health,Bethesda,MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Jake Liang","sequence":"additional","affiliation":[{"name":"Liver Diseases Branch,National Institutes of Diabetes and Digestive and Kidney Diseases,National Institutes of Health,Bethesda,MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard B.","family":"Seeff","sequence":"additional","affiliation":[{"name":"Einstein Healthcare Network,Philadelphia,PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Weill Cornell Medical College,New York,NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9667-7742","authenticated-orcid":false,"given":"Jorge A.","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology and Nutrition of Cincinnati Children\u2019s Hospital Medical Center,University of Cincinnati,Cincinnati,OH"},{"name":"Department of Pediatrics,University of Cincinnati,Cincinnati,OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond T.","family":"Chung","sequence":"additional","affiliation":[{"name":"Gastrointestinal Unit,Massachusetts General Hospital,Boston,MA"},{"name":"Department of Medicine,Harvard Medical School,Boston,MA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2021,10,5]]},"reference":[{"key":"hep31830-bib-0001-20250824","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20102019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","year":"2020","journal-title":"Lancet"},{"key":"hep31830-bib-0002-20250824","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1001\/jama.1943.02840170016005","article-title":"Jaundice occurring one to four weeks after transfusion of blood or plasma. 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