{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:45:27Z","timestamp":1785296727343,"version":"3.55.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n            <jats:title>Background and Aims<\/jats:title>\n            <jats:p>We compared risk of acute liver injury and mortality in patients with COVID\u201019 and current, past, and no HBV infection.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results<\/jats:title>\n            <jats:p>This was a territory\u2010wide retrospective cohort study in Hong Kong. Patients with COVID\u201019 between January 23, 2020, and January 1, 2021, were identified. Patients with hepatitis C or no HBsAg results were excluded. The primary outcome was mortality. Acute liver injury was defined as alanine aminotransferase or aspartate aminotransferase \u22652 \u00d7 upper limit of normal (ULN; i.e., 80\u00a0U\/L), with total bilirubin \u22652 \u00d7 ULN (i.e., 2.2\u00a0mg\/dL) and\/or international normalized ratio \u22651.7. Of 5,639 patients included, 353 (6.3%) and 359 (6.4%) had current and past HBV infection, respectively. Compared to patients without known HBV exposure, current HBV\u2010infected patients were older and more likely to have cirrhosis. Past HBV\u2010infected patients were the oldest, and more had diabetes and cardiovascular disease. At a median follow\u2010up of 14 (9\u201020) days, 138 (2.4%) patients died; acute liver injury occurred in 58 (1.2%), 8 (2.3%), and 11 (3.1%) patients with no, current, and past HBV infection, respectively. Acute liver injury (adjusted HR [aHR], 2.45; 95% CI, 1.52\u20103.96; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0&lt;\u00a00.001), but not current (aHR, 1.29; 95% CI, 0.61\u20102.70; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.507) or past (aHR, 0.90; 95% CI, 0.56\u20101.46; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.681) HBV infection, was associated with mortality. Use of corticosteroid, antifungal, ribavirin, or lopinavir\u2013ritonavir (adjusted OR [aOR], 2.55\u20105.63), but not current (aOR, 1.93; 95% CI, 0.88\u20104.24; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.102) or past (aOR, 1.25; 95% CI, 0.62\u20102.55; <jats:italic toggle=\"yes\">P<\/jats:italic>\u00a0=\u00a00.533) HBV infection, was associated with acute liver injury.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Current or past HBV infections were not associated with more liver injury and mortality in COVID\u201019.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.31890","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T21:37:35Z","timestamp":1620509855000},"page":"1750-1765","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":50,"title":["Current and Past Infections of HBV Do Not Increase Mortality in Patients With COVID\u201019"],"prefix":"10.1097","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1819-2464","authenticated-orcid":false,"given":"Terry Cheuk\u2010Fung","family":"Yip","sequence":"first","affiliation":[{"name":"Department of Medicine and Therapeutics,The Chinese University of Hong Kong,Hong Kong SAR,China"},{"name":"Medical Data Analytics Centre,The Chinese University of Hong Kong,Hong Kong SAR,China"},{"name":"Institute of Digestive Disease,The Chinese University of Hong Kong,Hong Kong SAR,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2215-9410","authenticated-orcid":false,"given":"Vincent Wai\u2010Sun","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics,The Chinese University of Hong Kong,Hong Kong SAR,China"},{"name":"Medical Data Analytics Centre,The Chinese University of Hong Kong,Hong Kong SAR,China"},{"name":"Institute of Digestive Disease,The Chinese University of Hong Kong,Hong Kong SAR,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace Chung\u2010Yan","family":"Lui","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics,The Chinese University of Hong Kong,Hong Kong SAR,China"},{"name":"Medical Data Analytics Centre,The Chinese University of Hong Kong,Hong Kong SAR,China"},{"name":"Stanley Ho Centre for Emerging Infectious Diseases,Jockey Club School of Public Health & Primary Care,The Chinese University of Hong Kong,Hong Kong SAR,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola Chi\u2010Ying","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Microbiology,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee\u2010Kit","family":"Tse","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics,The Chinese University of Hong Kong,Hong Kong SAR,China"},{"name":"Medical Data Analytics Centre,The Chinese University of Hong Kong,Hong Kong SAR,China"},{"name":"Institute of Digestive Disease,The Chinese University of Hong Kong,Hong Kong SAR,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki Wing\u2010Ki","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics,The Chinese University of Hong Kong,Hong Kong SAR,China"},{"name":"Medical Data Analytics Centre,The Chinese University of Hong Kong,Hong Kong SAR,China"},{"name":"Institute of Digestive Disease,The Chinese University of Hong Kong,Hong Kong SAR,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian Yan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics,The Chinese University of Hong Kong,Hong Kong SAR,China"},{"name":"Medical Data Analytics Centre,The Chinese University of Hong Kong,Hong Kong SAR,China"},{"name":"Institute of Digestive Disease,The Chinese University of Hong Kong,Hong Kong SAR,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry Lik\u2010Yuen","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics,The Chinese University of Hong Kong,Hong Kong SAR,China"},{"name":"Medical Data Analytics Centre,The Chinese University of Hong Kong,Hong Kong SAR,China"},{"name":"Institute of Digestive Disease,The Chinese University of Hong Kong,Hong Kong SAR,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Shu\u2010Cheong","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics,The Chinese University of Hong Kong,Hong Kong SAR,China"},{"name":"Medical Data Analytics Centre,The Chinese University of Hong Kong,Hong Kong SAR,China"},{"name":"Stanley Ho Centre for Emerging Infectious 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