{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T11:19:24Z","timestamp":1793963964455,"version":"4.8.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n            <jats:title>Background and Aims<\/jats:title>\n            <jats:p>Information is limited regarding HBV genotype and the outcome of chronic HBV (CHB) infection. We examined the effect of HBV genotype on HCC occurrence in Alaska Native (AN) persons with CHB, where five HBV genotypes are found: A2, B6, C2, D, and F1.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results<\/jats:title>\n            <jats:p>We calculated HCC incidence per 1,000 person\u2010years of follow\u2010up to determine which groups by age, sex, and genotype met current American Association for the Study of Liver Diseases (AASLD) HCC surveillance criteria. We used Poisson regression to compare HCC risk by genotype, age, sex, and Alaska region. Incidence of HCC was calculated using the sex\u2010specific AASLD cutoff recommended for the Asian population of 50\u00a0years for women and 40\u00a0years for men. HCC screening was conducted semiannually using alpha\u2010fetoprotein levels and abdominal ultrasound. Among 1,185 AN persons, median follow\u2010up was 35.1\u00a0years; 667 (63%) were male. The HBV genotype distribution was 49% D, 18% F, 13% A, 6% C, 3% B, 0.1% H, and 12% undetermined. Sixty\u2010three cases of HCC occurred. HCC incidence for genotype F was 5.73 per 1,000 person\u2010years of follow\u2010up, followed by 4.77 for C, 1.28 for A, 0.47 for D, and 0.00 for B. The HCC risk was higher for genotypes F (relative rate [RR], 12.7; 95% CI, 6.1\u201026.4), C (RR, 10.6; 95% CI, 4.3\u201026.0), and A (RR, 2.9; 95% CI, 1.0\u20108.0) compared to genotypes B and D. Among men\u00a0&lt;\u00a040\u00a0years of age and women\u00a0&lt;\u00a050\u00a0years of age, genotype F had the highest incidence (4.79\/1,000\u00a0person\u2010years).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>HBV genotype was strongly associated with HCC. HBV genotype should be considered in risk factor stratification.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.32065","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T08:49:16Z","timestamp":1626943756000},"page":"2965-2973","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":51,"title":["HBV Genotype: A Significant Risk Factor in Determining Which Patients With Chronic HBV Infection Should Undergo Surveillance for HCC: The Hepatitis B Alaska Study"],"prefix":"10.1097","volume":"74","author":[{"given":"Brian J.","family":"McMahon","sequence":"first","affiliation":[{"name":"Liver Disease and Hepatitis Program,Alaska Native Tribal Health Consortium,Anchorage,AK,USA"},{"name":"Division of Preparedness and Emerging Infections,National Center for Emerging and Zoonotic Infectious Diseases,Centers for Disease Control and Prevention,Arctic Investigations Program,Anchorage,AK,USA"},{"name":"Division of Viral Hepatitis,National Center for HIV,Viral Hepatitis,STD and TB Prevention,Centers for Disease Control and Prevention,Atlanta,GA,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leisha D.","family":"Nolen","sequence":"additional","affiliation":[{"name":"Division of Preparedness and Emerging Infections,National Center for Emerging and Zoonotic Infectious Diseases,Centers for Disease Control and Prevention,Arctic Investigations Program,Anchorage,AK,USA"},{"name":"Division of Viral Hepatitis,National Center for HIV,Viral Hepatitis,STD and TB Prevention,Centers for Disease Control and Prevention,Atlanta,GA,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Snowball","sequence":"additional","affiliation":[{"name":"Liver Disease and Hepatitis Program,Alaska Native Tribal Health Consortium,Anchorage,AK,USA"},{"name":"Division of Preparedness and Emerging Infections,National Center for Emerging and Zoonotic Infectious Diseases,Centers for Disease Control and Prevention,Arctic Investigations Program,Anchorage,AK,USA"},{"name":"Division of Viral Hepatitis,National Center for HIV,Viral Hepatitis,STD and TB Prevention,Centers for Disease Control and Prevention,Atlanta,GA,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chriss","family":"Homan","sequence":"additional","affiliation":[{"name":"Division of Preparedness and Emerging Infections,National Center for Emerging and Zoonotic Infectious Diseases,Centers for Disease Control and Prevention,Arctic Investigations Program,Anchorage,AK,USA"},{"name":"Division of Viral Hepatitis,National Center for HIV,Viral Hepatitis,STD and TB Prevention,Centers for Disease Control and Prevention,Atlanta,GA,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Negus","sequence":"additional","affiliation":[{"name":"Liver Disease and Hepatitis Program,Alaska Native Tribal Health Consortium,Anchorage,AK,USA"},{"name":"Division of Preparedness and Emerging Infections,National Center for Emerging and Zoonotic Infectious Diseases,Centers for Disease Control and Prevention,Arctic Investigations Program,Anchorage,AK,USA"},{"name":"Division of Viral Hepatitis,National Center for HIV,Viral Hepatitis,STD and TB Prevention,Centers for Disease Control and Prevention,Atlanta,GA,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Roik","sequence":"additional","affiliation":[{"name":"Division of Preparedness and Emerging Infections,National Center for Emerging and Zoonotic Infectious Diseases,Centers for Disease Control and Prevention,Arctic Investigations Program,Anchorage,AK,USA"},{"name":"Division of Viral Hepatitis,National Center for HIV,Viral Hepatitis,STD and TB Prevention,Centers for Disease Control and Prevention,Atlanta,GA,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip R.","family":"Spradling","sequence":"additional","affiliation":[{"name":"Division of Preparedness and Emerging Infections,National Center for Emerging and Zoonotic Infectious Diseases,Centers for Disease Control and Prevention,Arctic Investigations Program,Anchorage,AK,USA"},{"name":"Division of Viral Hepatitis,National Center for HIV,Viral Hepatitis,STD and TB Prevention,Centers for Disease Control and Prevention,Atlanta,GA,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Bruden","sequence":"additional","affiliation":[{"name":"Liver Disease and Hepatitis Program,Alaska Native Tribal Health Consortium,Anchorage,AK,USA"},{"name":"Division of Preparedness and Emerging Infections,National Center for Emerging and Zoonotic Infectious Diseases,Centers for Disease Control and Prevention,Arctic Investigations Program,Anchorage,AK,USA"},{"name":"Division of Viral Hepatitis,National Center for HIV,Viral Hepatitis,STD and TB Prevention,Centers for Disease 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