{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:36:14Z","timestamp":1790739374568,"version":"4.1.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Peroxisome proliferator\u2013activated receptor \u03b1 (PPAR\u03b1, NR1C1) is a ligand\u2010activated nuclear receptor involved in the regulation of lipid catabolism and energy homeostasis. PPAR\u03b1 activation induces hepatomegaly and plays an important role in liver regeneration, but the underlying mechanisms remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach and Results<\/jats:title>\n                    <jats:p>\n                      In this study, the effect of PPAR\u03b1 activation on liver enlargement and regeneration was investigated in several strains of genetically modified mice. PPAR\u03b1 activation by the specific agonist WY\u201014643 significantly induced hepatomegaly and accelerated liver regeneration after 70% partial hepatectomy (PHx) in wild\u2010type mice and\n                      <jats:italic toggle=\"yes\">Ppara<\/jats:italic>\n                      <jats:sup>fl\/fl<\/jats:sup>\n                      mice, while these effects were abolished in hepatocyte\u2010specific\n                      <jats:italic toggle=\"yes\">Ppara<\/jats:italic>\n                      \u2010deficient (\n                      <jats:italic toggle=\"yes\">Ppara<\/jats:italic>\n                      <jats:sup>\u0394Hep<\/jats:sup>\n                      ) mice. Moreover, PPAR\u03b1 activation promoted hepatocyte hypertrophy around the central vein area and hepatocyte proliferation around the portal vein area. Mechanistically, PPAR\u03b1 activation regulated expression of yes\u2010associated protein (YAP) and its downstream targets (connective tissue growth factor, cysteine\u2010rich angiogenic inducer 61, and ankyrin repeat domain 1) as well as proliferation\u2010related proteins (cyclins A1, D1, and E1). Binding of YAP with the PPAR\u03b1 E domain was critical for the interaction between YAP and PPAR\u03b1. PPAR\u03b1 activation further induced nuclear translocation of YAP. Disruption of the YAP\u2013transcriptional enhancer factor domain family member (TEAD) association significantly suppressed PPAR\u03b1\u2010induced hepatomegaly and hepatocyte enlargement and proliferation. In addition, PPAR\u03b1 failed to induce hepatomegaly in adeno\u2010associated virus\u2013\n                      <jats:italic toggle=\"yes\">Yap<\/jats:italic>\n                      short hairpin RNA\u2013treated mice and liver\u2010specific\n                      <jats:italic toggle=\"yes\">Yap<\/jats:italic>\n                      \u2010deficient mice. Blockade of YAP signaling abolished PPAR\u03b1\u2010induced hepatocyte hypertrophy around the central vein area and hepatocyte proliferation around the portal vein area.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study revealed a function of PPAR\u03b1 in regulating liver size and liver regeneration through activation of the YAP\u2013TEAD signaling pathway. These findings have implications for understanding the physiological functions of PPAR\u03b1 and suggest its potential for manipulation of liver size and liver regeneration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.32105","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T09:52:21Z","timestamp":1628848341000},"page":"74-88","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":109,"title":["YAP\u2010TEAD mediates PPAR \u03b1\u2013induced hepatomegaly and liver regeneration in mice"],"prefix":"10.1097","volume":"75","author":[{"given":"Shicheng","family":"Fan","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat\u2010Sen University,Guangzhou,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Gao","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat\u2010Sen University,Guangzhou,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijuan","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Capital Medical University,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Jiang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat\u2010Sen University,Guangzhou,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery,The Third Affiliated Hospital of Sun Yat\u2010sen University,Guangzhou,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guomin","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Capital Medical University,Beijing,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinpeng","family":"Yao","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat\u2010Sen University,Guangzhou,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat\u2010Sen University,Guangzhou,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery,The Third Affiliated Hospital of Sun Yat\u2010sen University,Guangzhou,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Yagai","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolism,Center for Cancer Research,National Cancer Institute,National Institutes of Health,Bethesda,Maryland,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Tian","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat\u2010Sen University,Guangzhou,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruimin","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat\u2010Sen University,Guangzhou,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolism,Center for Cancer Research,National Cancer Institute,National Institutes of Health,Bethesda,Maryland,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat\u2010Sen University,Guangzhou,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7094-2296","authenticated-orcid":false,"given":"Huichang","family":"Bi","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat\u2010Sen University,Guangzhou,China"},{"name":"School of Pharmaceutical Sciences,Southern Medical University,Guangzhou,China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"issue":"8","key":"hep32105-bib-0001-20250824","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nrgastro.2016.97","article-title":"Liver regeneration\u2014mechanisms and models to clinical application","volume":"13","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"4","key":"hep32105-bib-0002-20250824","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1002\/hep.28988","article-title":"Hepatostat: liver regeneration and normal liver tissue maintenance","volume":"65","year":"2017","journal-title":"Hepatology"},{"key":"hep32105-bib-0003-20250824","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1038\/sj.cdd.4401113","article-title":"Mitogenesis by ligands of nuclear receptors: an attractive model for the study of the molecular mechanisms implicated in liver growth","volume":"10","year":"2003","journal-title":"Cell Death Differ"},{"issue":"9","key":"hep32105-bib-0004-20250824","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1124\/dmd.120.000061","article-title":"Dexamethasone\u2010induced liver enlargement is related to PXR\/YAP activation and lipid accumulation but not hepatocyte proliferation","volume":"48","year":"2020","journal-title":"Drug Metab Dispos"},{"key":"hep32105-bib-0005-20250824","article-title":"PXR mediates mifepristone\u2010induced hepatomegaly in mice","year":"2021","journal-title":"Acta Pharmacol Sin"},{"key":"hep32105-bib-0006-20250824","doi-asserted-by":"crossref","first-page":"153520","DOI":"10.1016\/j.phymed.2021.153520","article-title":"Schisandrol B promotes liver enlargement via activation of PXR and YAP pathways in mice","volume":"84","year":"2021","journal-title":"Phytomedicine"},{"issue":"3","key":"hep32105-bib-0007-20250824","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1053\/j.gastro.2016.10.047","article-title":"Hippo signaling in the liver regulates organ size, cell fate, and carcinogenesis","volume":"152","year":"2017","journal-title":"Gastroenterology"},{"issue":"23","key":"hep32105-bib-0009-20250824","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.cub.2007.10.039","article-title":"YAP1 increases organ size and expands undifferentiated progenitor cells","volume":"17","year":"2007","journal-title":"Curr Biol"},{"issue":"8","key":"hep32105-bib-0010-20250824","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/ncb3389","article-title":"Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth","volume":"18","year":"2016","journal-title":"Nat Cell Biol"},{"issue":"352","key":"hep32105-bib-0011-20250824","first-page":"352ra108","article-title":"Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration","volume":"8","year":"2016","journal-title":"Sci Transl Med"},{"issue":"1","key":"hep32105-bib-0012-20250824","doi-asserted-by":"crossref","first-page":"46","DOI":"10.15252\/emmm.201506089","article-title":"Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2","volume":"9","year":"2017","journal-title":"EMBO Mol Med"},{"issue":"1","key":"hep32105-bib-0013-20250824","article-title":"Hippo pathway coactivators Yap and Taz are required to coordinate mammalian liver regeneration","volume":"50","year":"2018","journal-title":"Exp Mol Med"},{"issue":"6","key":"hep32105-bib-0014-20250824","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1002\/hep.24289","article-title":"Yes\u2010associated protein regulation of adaptive liver enlargement and hepatocellular carcinoma development in mice","volume":"53","year":"2011","journal-title":"Hepatology"},{"issue":"2","key":"hep32105-bib-0015-20250824","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/toxsci\/kfy149","article-title":"Role of YAP activation in nuclear receptor CAR\u2010mediated proliferation of mouse hepatocytes","volume":"165","year":"2018","journal-title":"Toxicol Sci"},{"issue":"1","key":"hep32105-bib-0016-20250824","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/hep.30131","article-title":"Pregnane X receptor regulates liver size and liver cell fate by yes\u2010associated protein activation in mice","volume":"69","year":"2019","journal-title":"Hepatology"},{"key":"hep32105-bib-0017-20250824","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1002\/hep.31521","article-title":"Yap is crucial for CAR\u2010driven hepatocyte proliferation, but not for induction of drug metabolism genes in mice","volume":"73","year":"2021","journal-title":"Hepatology"},{"issue":"3","key":"hep32105-bib-0018-20250824","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.apsb.2020.11.021","article-title":"Constitutive androstane receptor\u2013induced hepatomegaly and liver regeneration is partially via yes\u2010associated protein activation","volume":"11","year":"2021","journal-title":"Acta Pharm Sin B"},{"issue":"3","key":"hep32105-bib-0019-20250824","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1172\/JCI27989","article-title":"Sorting out the roles of PPAR \u03b1 in energy metabolism and vascular homeostasis","volume":"116","year":"2006","journal-title":"J Clin Invest"},{"issue":"10","key":"hep32105-bib-0020-20250824","first-page":"1396","article-title":"Hepatocyte peroxisome proliferator\u2013activated receptor \u03b1 regulates bile acid synthesis and transport","volume":"10","year":"2019","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"issue":"1","key":"hep32105-bib-0021-20250824","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1146\/annurev.pharmtox.40.1.491","article-title":"Central role of peroxisome proliferator\u2013activated receptors in the actions of peroxisome proliferators","volume":"40","year":"2000","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"11","key":"hep32105-bib-0022-20250824","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1093\/carcin\/18.11.2029","article-title":"Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy\u201014,643","volume":"18","year":"1997","journal-title":"Carcinogenesis"},{"issue":"3","key":"hep32105-bib-0023-20250824","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1053\/jhep.2002.35276","article-title":"Delayed liver regeneration in peroxisome proliferator\u2013activated receptor\u2010\u03b1\u2010null mice","volume":"36","year":"2002","journal-title":"Hepatology"},{"issue":"2","key":"hep32105-bib-0024-20250824","doi-asserted-by":"crossref","first-page":"G302","DOI":"10.1152\/ajpgi.00175.2002","article-title":"Impaired Ras membrane association and activation in PPAR \u03b1 knockout mice after partial hepatectomy","volume":"284","year":"2003","journal-title":"Am J Physiol Gastroint Liver Physiol"},{"issue":"2","key":"hep32105-bib-0025-20250824","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ajpath.2018.10.009","article-title":"Hepatocyte peroxisome proliferator\u2013activated receptor \u03b1 enhances liver regeneration after partial hepatectomy in mice","volume":"189","year":"2019","journal-title":"Am J Pathol"},{"issue":"3","key":"hep32105-bib-0026-20250824","doi-asserted-by":"crossref","first-page":"G283","DOI":"10.1152\/ajpgi.00205.2016","article-title":"Hepatocyte\u2010specific PPARA expression exclusively promotes agonist\u2010induced cell proliferation without influence from nonparenchymal cells","volume":"312","year":"2017","journal-title":"Am J Physiol Gastroint Liver Physiol"},{"issue":"4","key":"hep32105-bib-0027-20250824","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.cell.2015.10.044","article-title":"Hippo pathway in organ size control, tissue homeostasis, and cancer","volume":"163","year":"2015","journal-title":"Cell"},{"issue":"2","key":"hep32105-bib-0028-20250824","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jhep.2013.09.024","article-title":"Role of Myc in hepatocellular proliferation and hepatocarcinogenesis","volume":"60","year":"2014","journal-title":"J Hepatol"},{"issue":"6","key":"hep32105-bib-0029-20250824","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.cell.2007.07.019","article-title":"Elucidation of a universal size\u2010control mechanism in Drosophila and mammals","volume":"130","year":"2007","journal-title":"Cell"},{"issue":"4","key":"hep32105-bib-0030-20250824","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1172\/JCI88893","article-title":"Nutrient\u2010sensing nuclear receptors PPAR\u03b1 and FXR control liver energy balance","volume":"127","year":"2017","journal-title":"J Clin Invest"},{"issue":"2","key":"hep32105-bib-0031-20250824","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1093\/toxsci\/kfq259","article-title":"PPAR\u03b1\u2010dependent activation of cell cycle control and DNA repair genes in hepatic nonparenchymal cells","volume":"118","year":"2010","journal-title":"Toxicol Sci"},{"issue":"6","key":"hep32105-bib-0032-20250824","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/carcin\/bgm046","article-title":"Hepatocyte\u2010restricted constitutive activation of PPAR \u03b1 induces hepatoproliferation but not hepatocarcinogenesis","volume":"28","year":"2007","journal-title":"Carcinogenesis"},{"issue":"1","key":"hep32105-bib-0033-20250824","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.tox.2007.09.030","article-title":"PPAR\u03b1: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators","volume":"246","year":"2008","journal-title":"Toxicology"},{"issue":"11","key":"hep32105-bib-0034-20250824","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1158\/0008-5472.CAN-04-0322","article-title":"Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator\u2013activated receptor \u03b1","volume":"64","year":"2004","journal-title":"Cancer Res"},{"issue":"1","key":"hep32105-bib-0035-20250824","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/toxsci\/kfm206","article-title":"The PPAR \u03b1\u2010humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR \u03b1","volume":"101","year":"2008","journal-title":"Toxicol Sci"},{"issue":"13","key":"hep32105-bib-0036-20250824","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.cub.2012.05.016","article-title":"Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration","volume":"22","year":"2012","journal-title":"Curr Biol"},{"issue":"4","key":"hep32105-bib-0037-20250824","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.tcb.2013.10.005","article-title":"Compensatory cellular hypertrophy: the other strategy for tissue homeostasis","volume":"24","year":"2014","journal-title":"Trends Cell Biol"},{"issue":"2","key":"hep32105-bib-0039-20250824","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.livres.2020.03.001","article-title":"Nuclear receptors and non\u2010alcoholic fatty liver disease: an update","volume":"4","year":"2020","journal-title":"Liver Res"},{"issue":"15","key":"hep32105-bib-0040-20250824","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1056\/NEJMra065156","article-title":"Medical progress: strategies for safer liver surgery and partial liver transplantation","volume":"356","year":"2007","journal-title":"N Engl J Med"},{"key":"hep32105-bib-0041-20250824","article-title":"YAP regulates cell size and growth dynamics via non\u2010cell autonomous mediators","volume":"9","year":"2020","journal-title":"eLife"},{"issue":"1","key":"hep32105-bib-0042-20250824","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/hep.30530","article-title":"Keratin 23 is a peroxisome proliferator\u2013activated receptor \u03b1\u2013dependent, MYC\u2010amplified oncogene that promotes hepatocyte proliferation","volume":"70","year":"2019","journal-title":"Hepatology"},{"key":"hep32105-bib-0043-20250824","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1002\/hep.31120","article-title":"Cooperation between MYC and \u03b2\u2010catenin in liver tumorigenesis requires Yap\/Taz","volume":"72","year":"2020","journal-title":"Hepatology"},{"issue":"12","key":"hep32105-bib-0044-20250824","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1158\/0008-5472.CAN-17-3487","article-title":"YAP\/TAZ initiates gastric tumorigenesis via upregulation of MYC","volume":"78","year":"2018","journal-title":"Cancer Res"},{"issue":"14","key":"hep32105-bib-0045-20250824","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1101\/gad.1664408","article-title":"TEAD mediates YAP\u2010dependent gene induction and growth control","volume":"22","year":"2008","journal-title":"Genes Dev"},{"issue":"12","key":"hep32105-bib-0046-20250824","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1101\/gad.192856.112","article-title":"Genetic and pharmacological disruption of the TEAD\u2013YAP complex suppresses the oncogenic activity of YAP","volume":"26","year":"2012","journal-title":"Genes Dev"},{"issue":"11","key":"hep32105-bib-0047-20250824","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.tibs.2017.09.003","article-title":"Regulation of the hippo pathway transcription factor TEAD","volume":"42","year":"2017","journal-title":"Trends Biochem Sci"},{"key":"hep32105-bib-0048-20250824","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.redox.2017.01.012","article-title":"Metabolic zonation of the liver: the oxygen gradient revisited","volume":"11","year":"2017","journal-title":"Redox Biol"},{"issue":"2","key":"hep32105-bib-0049-20250824","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/hep.1840200229","article-title":"Zonal heterogeneity of peroxisomal enzymes in rat liver: differential induction by three divergent hypolipidemic drugs","volume":"20","year":"1994","journal-title":"Hepatology"},{"key":"hep32105-bib-0050-20250824","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev-pathol-020117-044010","article-title":"Wnt\/\u03b2\u2010catenin signaling in liver development, homeostasis, and pathobiology","volume":"13","year":"2018","journal-title":"Annu Rev Pathol"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hep.32105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hep.32105","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1002\/hep.32105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T23:01:14Z","timestamp":1756076474000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1002\/hep.32105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,15]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.32105","relation":{},"ISSN":["0270-9139","1527-3350"],"issn-type":[{"value":"0270-9139","type":"print"},{"value":"1527-3350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,15]]},"assertion":[{"value":"2021-01-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}