{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:58:58Z","timestamp":1773802738522,"version":"3.50.1"},"reference-count":72,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T00:00:00Z","timestamp":1637971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T00:00:00Z","timestamp":1637971200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Alcohol\u2010associated liver disease (ALD) is emerging worldwide as the leading cause of liver\u2010related morbidity, mortality, and indication for liver transplantation. The ALD Special Interest Group and the Clinical Research Committee at the digital American Association for the Study of Liver Diseases meeting in November 2020\u00a0held the scientific sessions to identify clinical unmet needs in ALD, and addressing these needs using clinical research methodologies. Of several research methodologies, the sessions were focused on (a) studying disease burden of ALD using large administrative databases, (b) developing biomarkers for noninvasive diagnosis of alcohol\u2010associated hepatitis (AH) and estimation of disease prognosis, (c) identifying therapeutic targets for ALD and AH, (d) deriving accurate models to predict prognosis or posttransplant alcohol relapse as a basis for developing treatment algorithm and a uniform protocol on patient\u2010selection criteria for liver transplantation, and (e) examining qualitative research methodologies in studying the barriers to implementation of multidisciplinary integrated care model by hepatology and addiction teams for the management of dual pathology of liver disease and of alcohol use disorder. Prospective multicenter studies are required to address many of these clinical unmet needs. Further, multidisciplinary care models are needed to improve long\u2010term outcomes in patients with ALD.<\/jats:p>","DOI":"10.1002\/hep.32143","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T16:28:56Z","timestamp":1631118536000},"page":"1026-1037","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":41,"title":["Research methodologies to address clinical unmet needs and challenges in alcohol\u2010associated liver disease"],"prefix":"10.1097","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1207-3998","authenticated-orcid":false,"given":"Ashwani K.","family":"Singal","sequence":"first","affiliation":[{"name":"Department of Internal Medicine,University of South Dakota Sanford School of Medicine,Sioux Falls,South Dakota,USA"},{"name":"Division of Gastroenterology and Hepatology,Avera Transplant Institute,Sioux Falls,South Dakota,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Kwo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Stanford University Medical Center,Stanford,California,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Kwong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Stanford University Medical Center,Stanford,California,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suthat","family":"Liangpunsakul","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Indiana University,Indianapolis,Indiana,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5293-007X","authenticated-orcid":false,"given":"Alexandre","family":"Louvet","sequence":"additional","affiliation":[{"name":"Division of Hepatology,Hospital Huriez,Lille,France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pranoti","family":"Mandrekar","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Sciences,UMass Medical School,Worcester,Massachusetts,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"McClain","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition,Department of Medicine,University of Louisville,Louisville,Kentucky,USA"},{"name":"Department of Pharmacology and Toxicology,University of Louisville School of Medicine,Louisville,Kentucky,USA"},{"name":"Alcohol Research Center,University of Louisville School of Medicine,Louisville,Kentucky,USA"},{"name":"Robley Rex Veterans Affairs Medical Center,Louisville,Kentucky,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7364-5035","authenticated-orcid":false,"given":"Jessica","family":"Mellinger","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,University of Michigan,Ann Arbor,Michigan,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyongyi","family":"Szabo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,Beth Israel Deaconess Medical Center,Harvard Medical School,Boston,Massachusetts,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4143-1950","authenticated-orcid":false,"given":"Norah","family":"Terrault","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology,University of Southern California,Los Angeles,California,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Thursz","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases,Imperial College London,London,UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2355-7317","authenticated-orcid":false,"given":"Gerald S.","family":"Winder","sequence":"additional","affiliation":[{"name":"Department of Psychiatry,University of Michigan,Ann Arbor,Michigan,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3030-860X","authenticated-orcid":false,"given":"W. 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