{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:49:29Z","timestamp":1790765369405,"version":"4.1.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background and Aims<\/jats:title>\n            <jats:p>Hepatic ischemia\u2013reperfusion injury (IRI) is the leading cause of early posttransplantation organ failure as mitochondrial respiration and ATP production are affected. A shortage of donors has extended liver donor criteria, including aged or steatotic livers, which are more susceptible to IRI. Given the lack of an effective treatment and the extensive transplantation waitlist, we aimed at characterizing the effects of an accelerated mitochondrial activity by silencing methylation\u2010controlled J protein (MCJ) in three preclinical models of IRI and liver regeneration, focusing on metabolically compromised animal models.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results<\/jats:title>\n            <jats:p>Wild\u2010type (WT), MCJ knockout (KO), and <jats:italic toggle=\"yes\">Mcj<\/jats:italic> silenced WT mice were subjected to 70% partial hepatectomy (Phx), prolonged IRI, and 70% Phx with IRI. Old and young mice with metabolic syndrome were also subjected to these procedures. Expression of MCJ, an endogenous negative regulator of mitochondrial respiration, increases in preclinical models of Phx with or without vascular occlusion and in donor livers. Mice lacking MCJ initiate liver regeneration 12\u00a0h faster than WT and show reduced ischemic injury and increased survival. MCJ knockdown enables a mitochondrial adaptation that restores the bioenergetic supply for enhanced regeneration and prevents cell death after IRI. Mechanistically, increased ATP secretion facilitates the early activation of Kupffer cells and production of TNF, IL\u20106, and heparin\u2010binding EGF, accelerating the priming phase and the progression through G<jats:sub>1<\/jats:sub>\/S transition during liver regeneration. Therapeutic silencing of MCJ in 15\u2010month\u2010old mice and in mice fed a high\u2010fat\/high\u2010fructose diet for 12\u00a0weeks improves mitochondrial respiration, reduces steatosis, and overcomes regenerative limitations.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Boosting mitochondrial activity by silencing MCJ could pave the way for a protective approach after major liver resection or IRI, especially in metabolically compromised, IRI\u2010susceptible organs.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.32149","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T14:29:57Z","timestamp":1631456997000},"page":"550-566","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":61,"title":["Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals"],"prefix":"10.1097","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4569-028X","authenticated-orcid":false,"given":"Naroa","family":"Goikoetxea\u2010Usandizaga","sequence":"first","affiliation":[{"name":"Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE),Basque Research and Technology Alliance,Derio,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4183-6384","authenticated-orcid":false,"given":"Marina","family":"Serrano\u2010Maci\u00e1","sequence":"additional","affiliation":[{"name":"Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE),Basque Research and Technology Alliance,Derio,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa C.","family":"Delgado","sequence":"additional","affiliation":[{"name":"Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE),Basque Research and Technology Alliance,Derio,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Sim\u00f3n","sequence":"additional","affiliation":[{"name":"Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE),Basque Research and Technology Alliance,Derio,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Fern\u00e1ndez Ramos","sequence":"additional","affiliation":[{"name":"Precision Medicine and Liver Metabolism Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE),Basque Research and Technology Alliance,Derio,Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd),Carlos III National Health Institute,Madrid,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Barriales","sequence":"additional","affiliation":[{"name":"Inflammation and Macrophage Plasticity Laboratory,Center for Cooperative Research in Biosciences (CIC bioGUNE),Basque Research and Technology Alliance,Derio,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u00a0E.","family":"Cornide","sequence":"additional","affiliation":[{"name":"Liver, Digestive System and Metabolism Department, Liver Transplantation and Graft Viability Lab,Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Liver, Digestive System and Metabolism Department, Liver Transplantation and Graft Viability Lab,Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"P\u00e9rez\u2010Redondo","sequence":"additional","affiliation":[{"name":"Transplant Coordination Unit, Puerta de Hierro University Hospital,Madrid,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Lachiondo\u2010Ortega","sequence":"additional","affiliation":[{"name":"Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE),Basque Research and Technology Alliance,Derio,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n","family":"Rodr\u00edguez\u2010Agudo","sequence":"additional","affiliation":[{"name":"Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE),Basque Research and Technology Alliance,Derio,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maider","family":"Bizkarguenaga","sequence":"additional","affiliation":[{"name":"Precision Medicine and Liver Metabolism Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE),Basque Research and Technology Alliance,Derio,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Diego","family":"Zalamea","sequence":"additional","affiliation":[{"name":"Structure and Cell Biology of Viruses Lab Center for Cooperative Research in Biosciences (CIC bioGUNE),Basque Research and Technology Alliance,Derio,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel T.","family":"Pasco","sequence":"additional","affiliation":[{"name":"Inflammation and Macrophage Plasticity Laboratory,Center for Cooperative Research in Biosciences (CIC bioGUNE),Basque Research and Technology Alliance,Derio,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Caballero\u2010D\u00edaz","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd),Carlos III National Health Institute,Madrid,Spain"},{"name":"TGF\u2010\u03b2 and Cancer Group,Oncobell Program,Bellvitge Biomedical Research Institute (IDIBELL),Gran Via de L\u2019Hospitalet,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Alfano","sequence":"additional","affiliation":[{"name":"Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE),Basque Research and Technology Alliance,Derio,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miren","family":"Bravo","sequence":"additional","affiliation":[{"name":"Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE),Basque Research and Technology Alliance,Derio,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Gonz\u00e1lez\u2010Recio","sequence":"additional","affiliation":[{"name":"Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE),Basque Research and Technology Alliance,Derio,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2765-6432","authenticated-orcid":false,"given":"Maria","family":"Mercado\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE),Basque Research and Technology Alliance,Derio,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2220-0612","authenticated-orcid":false,"given":"Cl\u00e0udia","family":"Gil\u2010Pitarch","sequence":"additional","affiliation":[{"name":"Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE),Basque Research and Technology Alliance,Derio,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Mabe","sequence":"additional","affiliation":[{"name":"Electronics and Communications Unit, IK4\u2010Tekniker,Eibar,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7736-4089","authenticated-orcid":false,"given":"Jordi","family":"Gracia\u2010Sancho","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd),Carlos III National Health Institute,Madrid,Spain"},{"name":"Liver Vascular Biology Research Group,IDIBAPS,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Abecia","sequence":"additional","affiliation":[{"name":"Inflammation and Macrophage Plasticity Laboratory,Center for Cooperative Research in Biosciences (CIC bioGUNE),Basque Research and Technology Alliance,Derio,Spain"},{"name":"Immunology, Microbiology and Parasitology Department, Medicine and Nursing Faculty,University of the Basque Country,Leioa,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d3scar","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Laboratory of Diabetes and Vascular Pathology,IIS\u2010Fundaci\u00f3n Jim\u00e9nez D\u00edaz\u2010Universidad Aut\u00f3noma de Madrid, Spanish Biomedical Research Centre on Diabetes and Associated Metabolic Disorders (CIBERDEM) Network,Madrid,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Mart\u00edn\u2010Sanz","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd),Carlos III National Health Institute,Madrid,Spain"},{"name":"Cell Signalling and Metabolism Department,Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols,\u201d CSIC\u2010UAM,Madrid,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola G. A.","family":"Abrescia","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd),Carlos III National Health Institute,Madrid,Spain"},{"name":"Structure and Cell Biology of Viruses Lab Center for Cooperative Research in Biosciences (CIC bioGUNE),Basque Research and Technology Alliance,Derio,Spain"},{"name":"IKERBASQUE,Basque Foundation for Science,Bilbao,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Sabio","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares,Stress Kinases in Diabetes, Cancer and Biochemistry,Madrid,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Rinc\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Medicine,Immunobiology Division,University of Vermont,Burlington,Vermont,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2061-7182","authenticated-orcid":false,"given":"Juan","family":"Anguita","sequence":"additional","affiliation":[{"name":"Inflammation and Macrophage Plasticity Laboratory,Center for Cooperative Research in Biosciences (CIC bioGUNE),Basque Research and Technology Alliance,Derio,Spain"},{"name":"IKERBASQUE,Basque Foundation for Science,Bilbao,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0466-044X","authenticated-orcid":false,"given":"Eduardo","family":"Mi\u00f1ambres","sequence":"additional","affiliation":[{"name":"Transplant Coordination Unit, Marqu\u00e9s de Valdecilla University Hospital\u2013IDIVAL, Cantabria University,Santander,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Biofisika Institute, Centro Superior de Investigaciones Cient\u00edficas, and Department of Biochemisty, Faculty of Science and Technology,University of Basque Country,Leioa,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Berenguer","sequence":"additional","affiliation":[{"name":"Liver Unit,Hospital Universitario y Polit\u00e9cnico La Fe,Valencia,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Fabregat","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd),Carlos III National Health Institute,Madrid,Spain"},{"name":"TGF\u2010\u03b2 and Cancer Group,Oncobell Program,Bellvitge Biomedical Research Institute (IDIBELL),Gran Via de L\u2019Hospitalet,Barcelona,Spain"},{"name":"Faculty of Medicine and Health Sciences,University of Barcelona,L\u2019Hospitalet,Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Casado","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd),Carlos III National Health Institute,Madrid,Spain"},{"name":"Experimental Metabolic Pathology Department,Instituto de Biomedicina de Valencia,IBV\u2010CSIC,Valencia,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5767-0676","authenticated-orcid":false,"given":"Carmen","family":"Peralta","sequence":"additional","affiliation":[{"name":"Liver, Digestive System and Metabolism Department, Liver Transplantation and Graft Viability Lab,Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer (IDIBAPS),Barcelona,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Varela\u2010Rey","sequence":"additional","affiliation":[{"name":"Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE),Basque Research and Technology Alliance,Derio,Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd),Carlos III National Health Institute,Madrid,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6446-9911","authenticated-orcid":false,"given":"Mar\u00eda Luz","family":"Mart\u00ednez\u2010Chantar","sequence":"additional","affiliation":[{"name":"Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE),Basque Research and Technology Alliance,Derio,Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd),Carlos III National Health Institute,Madrid,Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"key":"hep32149-bib-0001-20250824","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S2468-1253(18)30213-9","article-title":"Stretching the boundaries for liver transplant in the 21st century","volume":"3","year":"2018","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"hep32149-bib-0002-20250824","doi-asserted-by":"crossref","first-page":"4438","DOI":"10.3748\/wjg.v22.i18.4438","article-title":"Liver transplantation current status and challenges","volume":"22","year":"2016","journal-title":"World J Gastroenterol"},{"key":"hep32149-bib-0003-20250824","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease\u2014meta\u2010analytic assessment of prevalence, incidende, and outcomes","volume":"64","year":"2016","journal-title":"Hepatology"},{"key":"hep32149-bib-0004-20250824","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/tri.13288","article-title":"Fat and liver transplantation: clinical implications","volume":"31","year":"2018","journal-title":"Transpl Int"},{"key":"hep32149-bib-0005-20250824","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1002\/lt.24841","article-title":"Pushing the donor limits: deceased donor liver transplantation using organs from octogenarian donors","volume":"23","year":"2017","journal-title":"Liver Transplant"},{"key":"hep32149-bib-0006-20250824","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.jhep.2016.06.006","article-title":"Liver resection for cancer: new developments in prediction, prevention and management of postresectional liver failure","volume":"65","year":"2016","journal-title":"J Hepatol"},{"key":"hep32149-bib-0007-20250824","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/lt.21100","article-title":"Increased ischemic injury in old mouse liver: an ATP\u2010dependent mechanism","volume":"13","year":"2007","journal-title":"Liver Transplant"},{"key":"hep32149-bib-0008-20250824","doi-asserted-by":"crossref","first-page":"248","DOI":"10.7150\/ijms.22891","article-title":"Recent insights into mitochondrial targeting strategies in liver transplantation","volume":"15","year":"2018","journal-title":"Int J Med Sci"},{"key":"hep32149-bib-0009-20250824","first-page":"1543","article-title":"ATP\u2010supplies in the cold\u2010preserved liver: a long\u2010neglected factor of organ viability","volume":"36","year":"1987","journal-title":"Hepatology"},{"key":"hep32149-bib-0010-20250824","first-page":"54","article-title":"ATP release after partial hepatectomy regulates liver regeneration in the rat","volume":"52","year":"2013","journal-title":"J Hepatol"},{"key":"hep32149-bib-0011-20250824","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1097\/01.sla.0000251747.80025.b7","article-title":"Hepatic steatosis is a risk factor for postoperative complications after major hepatectomy","volume":"245","year":"2007","journal-title":"Ann Surg"},{"key":"hep32149-bib-0012-20250824","first-page":"1","article-title":"Purinergic signalling in liver diseases: pathological functions and therapeutic opportunities","volume":"2","year":"2020","journal-title":"J Hepatol Rep"},{"key":"hep32149-bib-0013-20250824","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1128\/MCB.00189-13","article-title":"MCJ\/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations","volume":"33","year":"2013","journal-title":"Mol Cell Biol"},{"key":"hep32149-bib-0014-20250824","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/infdis\/jiu389","article-title":"Regulation of oxidative stress by methylation\u2010controlled J protein controls macrophage responses to inflammatory insults","volume":"211","year":"2015","journal-title":"J Infect Dis"},{"key":"hep32149-bib-0015-20250824","article-title":"The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen\u2010induced liver injury","volume":"8","year":"2017","journal-title":"Nat Commun"},{"key":"hep32149-bib-0016-20250824","first-page":"1","article-title":"Silencing hepatic MCJ attenuates non\u2010alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation","volume":"11","year":"2020","journal-title":"Nat Commun"},{"key":"hep32149-bib-0017-20250824","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/hep.28134","article-title":"Dissecting the role of epidermal growth factor receptor catalytic activity during liver regeneration and hepatocarcinogenesis","volume":"63","year":"2016","journal-title":"Hepatology"},{"key":"hep32149-bib-0018-20250824","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s00109-019-01811-y","article-title":"Relevance of VEGFA in rat livers subjected to partial hepatectomy under ischemia\u2013reperfusion","volume":"97","year":"2019","journal-title":"J Mol Med"},{"key":"hep32149-bib-0019-20250824","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/hep.30241","article-title":"Protective role of hepatocyte cyclooxygenase\u20102 expression against liver ischemia\u2013reperfusion injury in mice","volume":"70","year":"2019","journal-title":"Hepatology"},{"key":"hep32149-bib-0020-20250824","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.jhep.2018.12.013","article-title":"Normothermic regional perfusion vs. super\u2010rapid recovery in controlled donation after circulatory death liver transplantation","volume":"70","year":"2019","journal-title":"J Hepatol"},{"key":"hep32149-bib-0021-20250824","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nrgastro.2016.97","article-title":"Liver regeneration\u2014mechanisms and models to clinical application","volume":"13","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"hep32149-bib-0022-20250824","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1002\/hep.28988","article-title":"Hepatostat: liver regeneration and normal liver tissue maintenance","volume":"65","year":"2017","journal-title":"Hepatology"},{"key":"hep32149-bib-0023-20250824","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0024-3205(81)90731-1","article-title":"Changes in predominant energy substrates after hepatectomy","volume":"28","year":"1981","journal-title":"Life Sci"},{"key":"hep32149-bib-0024-20250824","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2131\/jts.39.413","article-title":"Purinergic signaling via P2Y receptors up\u2010mediates IL\u20106 production by liver macrophages\/Kupffer cells","volume":"39","year":"2014","journal-title":"J Toxicol Sci"},{"key":"hep32149-bib-0025-20250824","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.1096\/fj.201802386R","article-title":"ATP redirects cytokine trafficking and promotes novel membrane TNF signaling via microvesicles","volume":"33","year":"2019","journal-title":"FASEB J"},{"key":"hep32149-bib-0026-20250824","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/08977194.2018.1453506","article-title":"Differential effects of epidermal growth factor (EGF) receptor ligands on receptor binding, downstream signalling pathways and DNA synthesis in hepatocytes","volume":"35","year":"2017","journal-title":"Growth Factors"},{"key":"hep32149-bib-0027-20250824","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jcmgh.2019.05.006","article-title":"Myeloid cell\u2013derived HB\u2010EGF drives tissue recovery after pancreatitis","volume":"8","year":"2019","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"hep32149-bib-0028-20250824","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1002\/hep.30774","article-title":"IL\u20106 trans\u2010signaling controls liver regeneration after partial hepatectomy","volume":"70","year":"2019","journal-title":"Hepatology"},{"key":"hep32149-bib-0029-20250824","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1074\/jbc.M412372200","article-title":"Heparin\u2010binding epidermal growth factor\u2010like growth factor links hepatocyte priming with cell cycle progression during liver regeneration","volume":"280","year":"2005","journal-title":"J Biol Chem"},{"key":"hep32149-bib-0030-20250824","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/hep.510300215","article-title":"Ischemia impairs liver regeneration after major tissue loss in rodents: protective effects of interleukin\u20106","volume":"30","year":"1999","journal-title":"Hepatology"},{"key":"hep32149-bib-0032-20250824","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1111\/liv.12433","article-title":"Functional hepatocellular regeneration in elderly patients undergoing hepatectomy","volume":"35","year":"2015","journal-title":"Liver Int"},{"key":"hep32149-bib-0033-20250824","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver diseases in the world","volume":"70","year":"2019","journal-title":"J Hepatol"},{"key":"hep32149-bib-0034-20250824","article-title":"Boosting mitochondria activity by silencing MCJ overcomes cholestasis\u2010induced liver injury","volume":"3","year":"2021","journal-title":"JHEP Rep"},{"key":"hep32149-bib-0035-20250824","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1096\/fj.03-1204fje","article-title":"Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A","volume":"18","year":"2004","journal-title":"FASEB J"},{"key":"hep32149-bib-0036-20250824","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.hpb.2017.08.005","article-title":"Bioenergetic adaptations of the human liver in the ALPPS procedure\u2014how liver regeneration correlates with mitochondrial energy status","volume":"19","year":"2017","journal-title":"HPB (Oxford)"},{"key":"hep32149-bib-0037-20250824","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/eci.12639","article-title":"Mitochondrial bioenergetics and posthepatectomy liver dysfunction","volume":"46","year":"2016","journal-title":"Eur J Clin Invest"},{"key":"hep32149-bib-0038-20250824","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1053\/jhep.2003.50268","article-title":"Interleukin 6\/gp130\u2010dependent pathways are protective during chronic liver diseases","volume":"38","year":"2003","journal-title":"Hepatology"},{"key":"hep32149-bib-0039-20250824","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1002\/hep.30954","article-title":"Hypoxia\u2010inducible factor (HIF)\u20102a reprograms liver macrophages to protect against acute liver injury via the production of interleukin\u20106","volume":"71","year":"2020","journal-title":"Hepatology"},{"key":"hep32149-bib-0040-20250824","first-page":"1","article-title":"Serum interleukin\u20106 and tumor necrosis factor\u2010\u03b1 are associated with early graft regeneration after living donor liver transplantation","volume":"13","year":"2018","journal-title":"PLoS ONE"},{"key":"hep32149-bib-0041-20250824","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.ajpath.2015.10.027","article-title":"Postponing the hypoglycemic response to partial hepatectomy delays mouse liver regeneration","volume":"186","year":"2016","journal-title":"Am J Pathol"},{"key":"hep32149-bib-0042-20250824","first-page":"5034","article-title":"Ischemia\/reperfusion injury revisited: an overview of the latest pharmacological strategies","volume":"20","year":"2019","journal-title":"Int J Med Sci"},{"key":"hep32149-bib-0043-20250824","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/j.transproceed.2010.02.084","article-title":"Activation of adenosine A2A receptor attenuates inflammatory response in a rat model of small\u2010for\u2010size liver transplantation","volume":"42","year":"2010","journal-title":"Transplant Proc"},{"key":"hep32149-bib-0044-20250824","doi-asserted-by":"crossref","first-page":"C670","DOI":"10.1152\/ajpcell.00213.2006","article-title":"The mitochondrial energy transduction system and the aging process","volume":"292","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"hep32149-bib-0045-20250824","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S1091-255X(98)80025-5","article-title":"Hepatic steatosis as a potential risk factor for major hepatic resection","volume":"2","year":"1998","journal-title":"J Gastrointest Surg"},{"key":"hep32149-bib-0046-20250824","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1055\/s-2001-12933","article-title":"Fatty liver in liver transplantation and surgery","volume":"21","year":"2001","journal-title":"Semin Liver Dis"}],"updated-by":[{"DOI":"10.1002\/hep.32505","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000}}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hep.32149","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hep.32149","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1002\/hep.32149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:03:11Z","timestamp":1756080191000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1002\/hep.32149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,15]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.32149","relation":{},"ISSN":["0270-9139","1527-3350"],"issn-type":[{"value":"0270-9139","type":"print"},{"value":"1527-3350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,15]]},"assertion":[{"value":"2021-02-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-24","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}