{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:21:36Z","timestamp":1790821296920,"version":"4.1.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"am","delay-in-days":271,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Although magnetic resonance elastography (MRE) has been well\u2010established for detecting and staging liver fibrosis, its prognostic role in determining outcomes of chronic liver disease (CLD) is mostly unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach and Results<\/jats:title>\n                    <jats:p>\n                      This retrospective study consisted of 1269\u00a0subjects who underwent MRE between 2007 and 2009 and followed up until death or last known clinical encounter or end of study period. Charts were reviewed for cirrhosis development, decompensation, and transplant or death. The cohort was split into baseline noncirrhosis (group 1), compensated cirrhosis (group 2), and decompensated cirrhosis (group 3). Cox\u2010regression analysis with age, sex, splenomegaly, CLD etiology, Child\u2010Pugh Score (CPS), Fibrosis\u20104 Index\u00a0(FIB\u20104) score, and Model for End\u2010Stage Liver Disease (MELD)\u2013adjusted HR for every 1\u2010kPa increase in liver stiffness measurement (LSM) were used to assess the predictive performance of MRE on outcomes. Group 1\u00a0(\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u00a0=\u00a0821) had baseline median LSM of 2.8\u00a0kPa, and cirrhosis developed in 72 (8.8%) subjects with an overall rate of about 1% cirrhosis\/year. Baseline LSM predicted the future cirrhosis with multivariable adjusted HR of 2.38 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) (concordance, 0.84). In\u00a0group 2\u00a0(\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u00a0=\u00a0277) with baseline median LSM of 5.7\u00a0kPa, 83 (30%) subjects developed decompensation. Baseline LSM predicted the future decompensation in cirrhosis with FIB\u20104 and MELD\u2010adjusted HR of 1.22 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) (concordance, 0.75). In\u00a0group 3\u00a0(\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u00a0=\u00a0171) with median baseline LSM of 6.8\u00a0kPa (5.2, 8.4), 113 (66%) subjects had either death or transplant. Baseline LSM predicted the future transplant or death with HR of 1.11 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u00a0=\u00a00.013) (concordance 0.53) but not in CPS and MELD\u2010adjusted models (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u00a0=\u00a00.08).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MRE\u2010based LSM is independently predictive of development of future cirrhosis and decompensation, and has predictive value in future transplant\/death in patients with CLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.32151","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T14:17:28Z","timestamp":1631456248000},"page":"379-390","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":56,"title":["Magnetic resonance elastography for prediction of long\u2010term progression and outcome in chronic liver disease: A retrospective study"],"prefix":"10.1097","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7237-3955","authenticated-orcid":false,"given":"Tolga","family":"Gidener","sequence":"first","affiliation":[{"name":"Department of Radiology,Mayo Clinic,Rochester,Minnesota,USA"},{"name":"Division of Gastroenterology and Hepatology,Mayo 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