{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:45:41Z","timestamp":1792431941115,"version":"4.5.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T00:00:00Z","timestamp":1644969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T00:00:00Z","timestamp":1644969600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background and Aims<\/jats:title>\n            <jats:p>NASH, which is a common clinical condition predisposing to advanced liver diseases, has become a worldwide epidemic. A large and growing unmet therapeutic need for this condition reflects incomplete understanding of its pathogenesis. In the current study, we identified a transcription factor, zinc fingers and homeoboxes 2 (ZHX2), in hepatocytes as a protective factor against steatohepatitis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Approach and Results<\/jats:title>\n            <jats:p>We found that hepatic ZHX2 was significantly suppressed in NASH models and steatotic hepatic cells. Hepatocyte\u2010specific ablation of ZHX2 exacerbated NASH\u2010related phenotypes in mice, including lipid accumulation, enhanced inflammation, and hepatic fibrosis. Conversely, hepatocyte\u2010specific overexpression of ZHX2 significantly alleviated the progression of NASH in an experimental setting. Integrated analysis of transcriptomic profiling and chromatin immunoprecipitation sequencing data demonstrated that the phosphatase and tensin homolog (PTEN) was a target gene of ZHX2 in hepatocyte. ZHX2 bound to the promoter of PTEN gene and subsequently promoted the transcription of PTEN, which mediated the beneficial role of ZHX2 against NASH.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The current findings demonstrate a protective role of ZHX2 against NASH progression by transcriptionally activating PTEN. These findings shed light on the therapeutic potential of targeting ZHX2 for treating NASH and related metabolic disorders.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.32165","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T04:45:50Z","timestamp":1632199550000},"page":"939-954","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":23,"title":["The transcription factor zinc fingers and homeoboxes 2 alleviates NASH by transcriptional activation of phosphatase and tensin homolog"],"prefix":"10.1097","volume":"75","author":[{"given":"Yichao","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory for Oncogenes and Related Genes,Division of Cardiology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai Cancer Institute,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingchen","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Oncogenes and Related Genes,Division of Cardiology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai Cancer Institute,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Graduate School of Bengbu Medical College,Bengbu,Anhui,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate School of Bengbu Medical College,Bengbu,Anhui,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Qin","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Oncogenes and Related Genes,Division of Cardiology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai Cancer Institute,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyuan","family":"Zhong","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Oncogenes and Related Genes,Division of Cardiology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai Cancer Institute,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Oncogenes and Related Genes,Division of Cardiology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai Cancer Institute,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renyang","family":"Tong","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Oncogenes and Related Genes,Division of Cardiology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai Cancer Institute,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Oncogenes and Related Genes,Division of Cardiology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai Cancer Institute,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ancai","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Oncogenes and Related Genes,Division of Cardiology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai Cancer Institute,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Pu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Oncogenes and Related Genes,Division of Cardiology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai Cancer Institute,Shanghai,China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,2,16]]},"reference":[{"key":"hep32165-bib-0001-20250824","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1126\/science.1204265","article-title":"Human fatty liver disease: old questions and new insights","volume":"332","year":"2011","journal-title":"Science"},{"key":"hep32165-bib-0002-20250824","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1002\/hep.30251","article-title":"Global perspectives on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"69","year":"2019","journal-title":"Hepatology"},{"key":"hep32165-bib-0003-20250824","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.jacc.2018.11.050","article-title":"Nonalcoholic fatty liver disease and the heart: JACC state\u2010of\u2010the\u2010art review","volume":"73","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"hep32165-bib-0004-20250824","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1152\/physrev.00065.2017","article-title":"Innate immune signaling and its role in metabolic and cardiovascular diseases","volume":"99","year":"2019","journal-title":"Physiol Rev"},{"key":"hep32165-bib-0005-20250824","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41575-019-0144-8","article-title":"Past, present and future perspectives in nonalcoholic fatty liver disease","volume":"16","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"hep32165-bib-0006-20250824","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","year":"2018","journal-title":"Nat Med"},{"key":"hep32165-bib-0007-20250824","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1053\/j.gastro.2016.02.066","article-title":"Pathogenesis of nonalcoholic steatohepatitis","volume":"150","year":"2016","journal-title":"Gastroenterology"},{"key":"hep32165-bib-0008-20250824","article-title":"Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis","volume":"10","year":"2018","journal-title":"Sci Transl Med"},{"key":"hep32165-bib-0009-20250824","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.gene.2003.09.013","article-title":"The mouse zinc\u2010fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3","volume":"323","year":"2003","journal-title":"Gene"},{"key":"hep32165-bib-0010-20250824","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1042\/bj20030171","article-title":"Zinc\u2010fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor","volume":"373","year":"2003","journal-title":"Biochem J"},{"key":"hep32165-bib-0011-20250824","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.leukres.2011.10.019","article-title":"Transcriptional deregulation of homeobox gene ZHX2 in Hodgkin lymphoma","volume":"36","year":"2012","journal-title":"Leuk Res"},{"key":"hep32165-bib-0012-20250824","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1126\/science.aap8411","article-title":"VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma","volume":"361","year":"2018","journal-title":"Science"},{"key":"hep32165-bib-0013-20250824","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1161\/CIRCGENETICS.109.902320","article-title":"Quantitative trait locus mapping and identification of Zhx2 as a novel regulator of plasma lipid metabolism","volume":"3","year":"2010","journal-title":"Circ Cardiovasc Genet"},{"key":"hep32165-bib-0014-20250824","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1053\/j.gastro.2012.02.049","article-title":"Zinc fingers and homeoboxes 2 inhibits hepatocellular carcinoma cell proliferation and represses expression of cyclins A and E","volume":"142","year":"2012","journal-title":"Gastroenterology"},{"key":"hep32165-bib-0015-20250824","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.antiviral.2018.03.008","article-title":"Tumor suppressor ZHX2 restricts hepatitis B virus replication via epigenetic and non\u2010epigenetic manners","volume":"153","year":"2018","journal-title":"Antiviral Res"},{"key":"hep32165-bib-0016-20250824","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nrd.2015.3","article-title":"Non\u2010alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies","volume":"15","year":"2016","journal-title":"Nat Rev Drug Discov"},{"key":"hep32165-bib-0017-20250824","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1002\/hep.29845","article-title":"Time to step\u2010up the fight against NAFLD","volume":"67","year":"2018","journal-title":"Hepatology"},{"key":"hep32165-bib-0018-20250824","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.cmet.2013.11.023","article-title":"The combined hyperlipidemia caused by impaired Wnt\u2010LRP6 signaling is reversed by Wnt3a rescue","volume":"19","year":"2014","journal-title":"Cell Metab"},{"key":"hep32165-bib-0019-20250824","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1172\/JCI20513","article-title":"Hepatocyte\u2010specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas","volume":"113","year":"2004","journal-title":"J Clin Invest"},{"key":"hep32165-bib-0020-20250824","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrm3330","article-title":"The functions and regulation of the PTEN tumour suppressor","volume":"13","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"hep32165-bib-0021-20250824","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-pathol-020117-043617","article-title":"Recent insights into the pathogenesis of nonalcoholic fatty liver disease","volume":"13","year":"2018","journal-title":"Annu Rev Pathol"},{"key":"hep32165-bib-0022-20250824","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1136\/gutjnl-2017-313884","article-title":"Non\u2010alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases","volume":"66","year":"2017","journal-title":"Gut"},{"key":"hep32165-bib-0023-20250824","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev-pathmechdis-012418-013003","article-title":"Innate immune signaling in nonalcoholic fatty liver disease and cardiovascular diseases","volume":"14","year":"2019","journal-title":"Annu Rev Pathol"},{"key":"hep32165-bib-0024-20250824","first-page":"322786","article-title":"Mortality in biopsy\u2010confirmed nonalcoholic fatty liver disease: results from a nationwide cohort","volume":"9","year":"2020","journal-title":"Gut"},{"key":"hep32165-bib-0025-20250824","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.jhep.2020.09.033","article-title":"Role of CC chemokine receptor 9 in the progression of murine and human non\u2010alcoholic steatohepatitis","volume":"74","year":"2021","journal-title":"J Hepatol"},{"key":"hep32165-bib-0026-20250824","article-title":"Liver ASK1 protects from non\u2010alcoholic fatty liver disease and fibrosis","volume":"11","year":"2019","journal-title":"EMBO Mol Med"},{"key":"hep32165-bib-0027-20250824","doi-asserted-by":"crossref","first-page":"154342","DOI":"10.1016\/j.metabol.2020.154342","article-title":"Revealing the role of peroxisome proliferator\u2013activated receptor \u03b2\/\u03b4 in nonalcoholic fatty liver disease","volume":"114","year":"2021","journal-title":"Metabolism"},{"key":"hep32165-bib-0028-20250824","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/s41467-019-09524-z","article-title":"Hepatocyte\u2010specific loss of GPS2 in mice reduces non\u2010alcoholic steatohepatitis via activation of PPAR\u03b1","volume":"10","year":"2019","journal-title":"Nat Commun"},{"key":"hep32165-bib-0029-20250824","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jhep.2014.01.001","article-title":"Failing FXR expression in the liver links aging to hepatic steatosis","volume":"60","year":"2014","journal-title":"J Hepatol"},{"key":"hep32165-bib-0030-20250824","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41568-019-0196-7","article-title":"Targeting transcription factors in cancer\u2014from undruggable to reality","volume":"19","year":"2019","journal-title":"Nat Rev Cancer"},{"key":"hep32165-bib-0031-20250824","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1002\/hep.30559","article-title":"Hepatic interferon regulatory factor 6 alleviates liver steatosis and metabolic disorder by transcriptionally suppressing peroxisome proliferator\u2013activated receptor \u03b3 in mice","volume":"69","year":"2019","journal-title":"Hepatology"},{"key":"hep32165-bib-0032-20250824","doi-asserted-by":"crossref","first-page":"7404","DOI":"10.1523\/JNEUROSCI.5841-08.2009","article-title":"ZHX2 Interacts with ephrin\u2010B and regulates neural progenitor maintenance in the developing cerebral cortex","volume":"29","year":"2009","journal-title":"J Neurosci"},{"key":"hep32165-bib-0033-20250824","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/path.5530","article-title":"ZHX2 inhibits SREBP1c\u2010mediated de novo lipogenesis in hepatocellular carcinoma via miR\u201024\u20103p","volume":"252","year":"2020","journal-title":"J Pathol"},{"key":"hep32165-bib-0034-20250824","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1002\/ijc.31595","article-title":"HBV suppresses ZHX2 expression to promote proliferation of HCC through miR\u2010155 activation","volume":"143","year":"2018","journal-title":"Int J Cancer"},{"key":"hep32165-bib-0035-20250824","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.18632\/oncotarget.2832","article-title":"ZHX2 enhances the cytotoxicity of chemotherapeutic drugs in liver tumor cells by repressing MDR1 via interfering with NF\u2010YA","volume":"6","year":"2015","journal-title":"Oncotarget"},{"key":"hep32165-bib-0036-20250824","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1111\/j.1582-4934.2008.00233.x","article-title":"ZHX2 is a repressor of alpha\u2010fetoprotein expression in human hepatoma cell lines","volume":"12","year":"2008","journal-title":"J Cell Mol Med"},{"key":"hep32165-bib-0037-20250824","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/hep.21825","article-title":"The oncofetal gene glypican 3 is regulated in the postnatal liver by zinc fingers and homeoboxes 2 and in the regenerating liver by alpha\u2010fetoprotein regulator 2","volume":"46","year":"2007","journal-title":"Hepatology"},{"key":"hep32165-bib-0038-20250824","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cmet.2018.10.012","article-title":"Preclinical models for studying NASH\u2010driven HCC: how useful are they?","volume":"29","year":"2019","journal-title":"Cell Metab"},{"key":"hep32165-bib-0039-20250824","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41575-019-0145-7","article-title":"From NASH to HCC: current concepts and future challenges","volume":"16","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"hep32165-bib-0040-20250824","doi-asserted-by":"crossref","first-page":"G965","DOI":"10.1152\/ajpgi.00132.2015","article-title":"Hepatocyte X\u2010box binding protein 1 deficiency increases liver injury in mice fed a high\u2010fat\/sugar diet","volume":"309","year":"2015","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"hep32165-bib-0041-20250824","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.biocel.2014.08.021","article-title":"Reduced nucleic ZHX2 involves in oncogenic activation of glypican 3 in human hepatocellular carcinoma","volume":"55","year":"2014","journal-title":"Int J Biochem Cell Biol"},{"key":"hep32165-bib-0042-20250824","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.4049\/jimmunol.1901246","article-title":"Zhx2 accelerates sepsis by promoting macrophage glycolysis via Pfkfb3","volume":"204","year":"2020","journal-title":"J Immunol"},{"key":"hep32165-bib-0043-20250824","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cell.2012.02.030","article-title":"Systemic elevation of PTEN induces a tumor\u2010suppressive metabolic state","volume":"149","year":"2012","journal-title":"Cell"},{"key":"hep32165-bib-0044-20250824","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1126\/science.275.5308.1943","article-title":"PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer","volume":"275","year":"1997","journal-title":"Science"},{"key":"hep32165-bib-0045-20250824","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nrc2222","article-title":"Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis","volume":"7","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"hep32165-bib-0046-20250824","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cmet.2008.07.007","article-title":"SREBP activity is regulated by mTORC1 and contributes to Akt\u2010dependent cell growth","volume":"8","year":"2008","journal-title":"Cell Metab"},{"key":"hep32165-bib-0047-20250824","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1002\/hep.22737","article-title":"Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA\u201021 up\u2010regulation in hepatocytes","volume":"49","year":"2009","journal-title":"Hepatology"},{"key":"hep32165-bib-0048-20250824","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1053\/j.gastro.2007.10.010","article-title":"PTEN down\u2010regulation by unsaturated fatty acids triggers hepatic steatosis via an NF\u2010kappaBp65\/mTOR\u2010dependent mechanism","volume":"134","year":"2008","journal-title":"Gastroenterology"},{"key":"hep32165-bib-0049-20250824","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1038\/s41418-019-0453-z","article-title":"Tumor suppressor ZHX2 inhibits NAFLD\u2010HCC progression via blocking LPL\u2010mediated lipid uptake","volume":"27","year":"2020","journal-title":"Cell Death Differ"},{"key":"hep32165-bib-0050-20250824","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1002\/hep.29689","article-title":"New insights into the role and mechanism of c\u2010Jun\u2010N\u2010terminal kinase signaling in the pathobiology of liver diseases","volume":"67","year":"2018","journal-title":"Hepatology"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hep.32165","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hep.32165","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1002\/hep.32165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:02:28Z","timestamp":1756080148000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1002\/hep.32165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,16]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.32165","relation":{},"ISSN":["0270-9139","1527-3350"],"issn-type":[{"value":"0270-9139","type":"print"},{"value":"1527-3350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,16]]},"assertion":[{"value":"2021-03-02","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}