{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:59:35Z","timestamp":1791885575034,"version":"4.3.4"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Hepatology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Hispanics are disproportionately affected by NAFLD, liver fibrosis, cirrhosis, and HCC. Preventive strategies and noninvasive means to identify those in this population at high risk for liver fibrosis, are urgently needed. We aimed to characterize the gut microbiome signatures and related biological functions associated with liver fibrosis in Hispanics and identify environmental and genetic factors affecting them.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach and Results<\/jats:title>\n                    <jats:p>\n                      Subjects of the population\u2010based Cameron County Hispanic Cohort (CCHC;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 217) were screened by vibration\u2010controlled transient elastography (FibroScan). Among them, 144 (66.7%) had steatosis and 28 (13.0%) had liver fibrosis. The gut microbiome of subjects with liver fibrosis was enriched with immunogenic commensals (e.g.,\n                      <jats:italic toggle=\"yes\">Prevotella copri<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Holdemanella,<\/jats:italic>\n                      Clostridiaceae 1) and depleted of\n                      <jats:italic toggle=\"yes\">Bacteroides caccae, Parabacteroides distasonis<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Enterobacter<\/jats:italic>\n                      , and Marinifilaceae. The liver fibrosis\u2010associated metagenome was characterized by changes in the urea cycle, L\u2010citrulline biosynthesis and creatinine degradation pathways, and altered synthesis of B vitamins and lipoic acid. These metagenomic changes strongly correlated with the depletion of\n                      <jats:italic toggle=\"yes\">Parabacteroides distasonis<\/jats:italic>\n                      and enrichment of\n                      <jats:italic toggle=\"yes\">Prevotella<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Holdemanella<\/jats:italic>\n                      . Liver fibrosis was also associated with depletion of bacterial pathways related to L\u2010fucose biosynthesis. Alcohol consumption, even moderate, was associated with high\n                      <jats:italic toggle=\"yes\">Prevotella<\/jats:italic>\n                      abundance. The single\u2010nucleotide polymorphisms rs3769502 and rs7573751 in the NCK adaptor protein 2 (\n                      <jats:italic toggle=\"yes\">NCK2<\/jats:italic>\n                      ) gene positively associated with high\n                      <jats:italic toggle=\"yes\">Prevotella<\/jats:italic>\n                      abundance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Hispanics with liver fibrosis display microbiome profiles and associated functional changes that may promote oxidative stress and a proinflammatory environment. These microbiome signatures, together with\n                      <jats:italic toggle=\"yes\">NCK2<\/jats:italic>\n                      polymorphisms, may have utility in risk modeling and disease prevention in this high\u2010risk population.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.32197","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T08:40:57Z","timestamp":1633941657000},"page":"955-967","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":59,"title":["Gut microbiome features associated with liver fibrosis in Hispanics, a population at high risk for fatty liver disease"],"prefix":"10.1097","volume":"75","author":[{"given":"Suet\u2010Ying","family":"Kwan","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Oncology,The University of Texas MD Anderson Cancer Center,Houston,Texas,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Oncology,The University of Texas MD Anderson Cancer Center,Houston,Texas,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aron","family":"Joon","sequence":"additional","affiliation":[{"name":"Department of Biostatistics,The University of Texas MD Anderson Cancer Center,Houston,Texas,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Biostatistics,The University of Texas MD Anderson Cancer Center,Houston,Texas,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Petty","sequence":"additional","affiliation":[{"name":"Vanderbilt Genetics Institute and Department of Genetic Medicine,Vanderbilt University Medical Center,Nashville,Tennessee,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Below","sequence":"additional","affiliation":[{"name":"Vanderbilt Genetics Institute and Department of Genetic Medicine,Vanderbilt University Medical Center,Nashville,Tennessee,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie R.","family":"Daniel","sequence":"additional","affiliation":[{"name":"Department of Epidemiology,The University of Texas MD Anderson Cancer Center,Houston,Texas,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine,The University of Texas MD Anderson Cancer Center,Houston,Texas,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine,The University of Texas MD Anderson Cancer Center,Houston,Texas,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R.","family":"Jenq","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine,The University of Texas MD Anderson Cancer Center,Houston,Texas,USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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